{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:20:31Z","timestamp":1765318831471,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"6392","license":[{"start":{"date-parts":[[1983,8,27]],"date-time":"1983-08-27T00:00:00Z","timestamp":430790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,8,27]]},"abstract":"<jats:p>Serum folate concentrations, blood counts, and antiepileptic drug concentrations were measured during 133 pregnancies of 125 women with epilepsy. There was an inverse correlation between serum folate concentrations and concentrations of phenytoin and phenobarbitone. The number of epileptic seizures during pregnancy showed no association with serum folate concentrations. No cases of maternal tissue folate deficiency or fetal damage attributable to low maternal serum folate were observed. Maternal serum folate concentrations for infants with structural birth defects, \"fetal hydantoin syndrome,\" or perinatal death were similar to those for healthy babies. A low dose (100 to 1000 micrograms daily) of folate supplement appeared sufficient for pregnant women with epilepsy despite the antifolic action of antiepileptic medication. Monitoring folate concentrations in pregnant women with high serum concentrations of phenytoin or phenobarbitone is recommended.<\/jats:p>","DOI":"10.1136\/bmj.287.6392.577","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"577-579","source":"Crossref","is-referenced-by-count":62,"title":["Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome."],"prefix":"10.1136","volume":"287","author":[{"given":"V K","family":"Hiilesmaa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Teramo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Bardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00003081-197912000-00004","article-title":"Folic acid and reproduction","volume":"22","author":"Kitay, D.Z.","year":"1979","unstructured":"Kitay DZ. 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Reinterpretation of the haematological effects of anticonvulsant treatment. Lancet 1978;i:1349-50.","journal-title":"J Pediatr"},{"volume":"ii:","first-page":"1255","key":"ref_10","unstructured":"Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr 1976;89: 662-8."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00016348109158126","article-title":"Plasma and red blood cell folate during normal pregnancies","volume":"60","author":"Ek, J.; Magnus, E.M.","year":"1981","unstructured":";ii: 1255-6.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref_12","first-page":"409","article-title":"Chronic toxicity in epileptic patients receiving single-drug treatment","volume":"285","author":"Dellaportas, D.I.; Shorvon, S.D.; Galbraith, A.W.","year":"1982","unstructured":"Ek J, Magnus EM. Plasma and red blood cell folate during normal pregnancies. Acta Obstet Gynecol Scand 1981;60:247-51."},{"key":"ref_13","first-page":"165","article-title":"Fetal head growth retardation associated with maternal antiepileptic drugs","volume":"ii:","author":"Hiilesmaa, V.K.; Teramo, K.; Granstrom, M.-L.; Bardy, A.H.","year":"1981","unstructured":"Dellaportas DI, Shorvon SD, Galbraith AW, et al. Chronic toxicity in epileptic patients receiving single-drug treatment. Br MedJ7 1982;285: 409-10.","journal-title":"Lancet"},{"key":"ref_14","first-page":"1313","article-title":"Valproate and malformations","volume":"ii:","author":"Anonymous","year":"1982","unstructured":"Hiilesmaa VK, Teramo K, Granstrom M-L, Bardy AH. Fetal head growth retardation associated with maternal antiepileptic drugs. Lancet 1981;ii: 165-7.","journal-title":"Lancet"},{"key":"ref_15","first-page":"1087","article-title":"Teratogenic risks of antiepileptic 1 Anonymous. Epilepsy drugs. 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