{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:15:43Z","timestamp":1766157343213,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"6393","license":[{"start":{"date-parts":[[1983,9,3]],"date-time":"1983-09-03T00:00:00Z","timestamp":431395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,9,3]]},"abstract":"<jats:p>Treatment and prognosis were studied in 122 patients with non-febrile seizures in a population of 6000. Phenytoin and phenobarbitone were the most commonly prescribed drugs, although the popularity of phenobarbitone had declined over time. The average duration of treatment was relatively short, and most patients received single drug treatment. Treatment patterns were erratic, and the surveillance and audit of treatment generally poor. Recurrence after a first attack was found in four fifths of the patients. Generally the total number of seizures suffered by each patient was small, the period of active epilepsy short, and remission when it occurred was usually permanent. The cumulative probability of continuing activity fell and the proportion of patients in remission rose over time. Patients with partial or mixed seizure types had a poorer overall prognosis. The course of the epilepsy in the early years of treatment proved to be a useful guide to the long term prognosis, and the possibility that effective treatment might influence long term prognosis is raised.<\/jats:p>","DOI":"10.1136\/bmj.287.6393.645","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"645-647","source":"Crossref","is-referenced-by-count":107,"title":["Epileptic seizures in a population of 6000. II: Treatment and prognosis."],"prefix":"10.1136","volume":"287","author":[{"given":"D M","family":"Goodridge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Shorvon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,9,3]]},"reference":[{"key":"ref_1","article-title":"Statistical methods in medical research","author":"Armitage, P.","year":"1971","unstructured":"Armitage P. Statistical methods in medical research. Oxford: Blackwell Scientific Publications, 1971."},{"key":"ref_2","first-page":"416","article-title":"the College of General Practitioners. A survey of the epilepsies in general practice. Br MedJ'","volume":"ii:","author":"Research Committee of","year":"1960","unstructured":"Research Committee of the College of General Practitioners. A survey of the epilepsies in general practice. Br MedJ' 1960;ii:416-22."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(77)91777-9","article-title":"How doctors deal with epilepsy","volume":"i:","author":"Hopkins, A.; Scambler, G.","year":"1977","unstructured":"Hopkins A, Scambler G. How doctors deal with epilepsy. Lancet 1977;i: 183-6.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1981.tb04327.x","article-title":"Monotherapy or polytherapy for epilepsy?","volume":"22","author":"Reynolds, E.H.; Shorvon, S.D.","year":"1981","unstructured":"Reynolds EH, Shorvon SD. Monotherapy or polytherapy for epilepsy? Epilepsia 1981;22:1-10.","journal-title":"Epilepsia"},{"key":"ref_5","first-page":"2","article-title":"Statistical analysis of pharmacokinetic parameters in epileptic patients chronically treated with antiepileptic drugs","volume-title":"Clinical pharmacology of antiepileptic drugs","author":"Guelan, P.J.M.; Van der Kleijn, E.; Woudstra, U.","year":"1975","unstructured":"Guelan PJM, Van der Kleijn E, Woudstra U. Statistical analysis of pharmacokinetic parameters in epileptic patients chronically treated with antiepileptic drugs. In: Schneider H, Janz D, Gardner-Thorpe C, Meinardi H, Sherwin AL, eds. Clinical pharmacology of antiepileptic drugs. Berlin: Springer-Verlag, 1975:2-10."},{"key":"ref_6","article-title":"The prognosis of patients with epilepsy","author":"Rodin, E.A.","year":"1968","unstructured":"Rodin EA. The prognosis of patients with epilepsy. Springfield: Charles Thomas, 1968."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archneur.1972.00490150001001","article-title":"Diagnostic factors in adult males following initial seizures","volume":"27","author":"Johnson, L.C.; Debolt, W.L.; Long, M.T.","year":"1972","unstructured":"Johnson LC, Debolt WL, Long MT, et al. Diagnostic factors in adult males following initial seizures. Arch Neurol 1972;27:193-7.","journal-title":"Arch Neurol"},{"key":"ref_8","first-page":"1364","article-title":"Prognosis of isolated seizures in adult life. Br MedJ'","volume":"283","author":"Cleland, P.G.; Mosquera, I.; Steward, W.P.; Foster, J.B.","year":"1981","unstructured":"Cleland PG, Mosquera I, Steward WP, Foster JB. Prognosis of isolated seizures in adult life. Br MedJ' 1981;283:1364."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1056\/NEJM198208263070903","article-title":"Seizure recurrence after a first unprovoked seizure","volume":"307","author":"Hauser, W.A.; Anderson, V.E.; Loewenson, R.B.; McRoberts, S.","year":"1982","unstructured":"Hauser WA, Anderson VE, Loewenson RB, McRoberts S. Seizure recurrence after a first unprovoked seizure. N Engl J Med 1982;307: 522-8.","journal-title":"N Engl J Med"},{"key":"ref_10","first-page":"1699","article-title":"Early prognosis of epilepsy","volume":"285","author":"Shorvon, S.D.; Reynolds, E.H.","year":"1982","unstructured":"Shorvon SD, Reynolds EH. Early prognosis of epilepsy. Br Med7 1982; 285:1699-701."},{"key":"ref_11","article-title":"The early prognosis of epilepsy","volume-title":"Advances in epileptology","author":"Elwes, R.; Shorvon, S.D.; Reynolds, E.H.","unstructured":"Elwes R, Shorvon SD, Reynolds EH. The early prognosis of epilepsy. In: Parsonage M, et al, eds. Advances in epileptology. New York: Raven Press (in press)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1528-1157.1979.tb04857.x","article-title":"Remission of seizures and relapse in patients with epilepsy","volume":"20","author":"Annergers, J.F.; Hauser, W.A.; Elveback, L.R.","year":"1979","unstructured":"Annergers JF, Hauser WA, Elveback LR. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979;20:729-37.","journal-title":"Epilepsia"},{"key":"ref_13","article-title":"Epilepsy and other chronic convulsive disorders","author":"Gowers, W.R.","year":"1881","unstructured":"Gowers WR. Epilepsy and other chronic convulsive disorders. London: Churchill, 1881."},{"article-title":"Accepted 24","year":"1983","key":"ref_14","unstructured":"(Accepted 24 May 1983)"},{"article-title":"CAPON WATER-\"Take a Capon the guts being pulled out, cut in pieces, the fat being taken away, boiled in a sufficient quantity of spring-water in a close vessel, take of this broth three pounds. Borrage and Violet-water, of each a pound and a half; white Wine one pound, red rose leaves two drams and an half, the flowers of Borrage, Violets and Bugloss, of each one dram, pieces of bread, hot out of the oven, half a pound, Cinnamon bruised, half an ounce, distil it in a glass still according to art.\" The simples are most of them appropriated to the heart, and in truth the composition greatly nourishes and strengthens such as are in consumptions, and restores lost strength, either by fevers or other sickness: It is a sovereign remedy for hectic fevers, and Marasmos, which is nothing else but a consumption coming from them. Let such as are subject to these diseases, hold it for a jewel. (Nicholas Culpeper (1616-54) The Complete Herbal","year":"1850","key":"ref_15","unstructured":"CAPON WATER-\"Take a Capon the guts being pulled out, cut in pieces, the fat being taken away, boiled in a sufficient quantity of spring-water in a close vessel, take of this broth three pounds. Borrage and Violet-water, of each a pound and a half; white Wine one pound, red rose leaves two drams and an half, the flowers of Borrage, Violets and Bugloss, of each one dram, pieces of bread, hot out of the oven, half a pound, Cinnamon bruised, half an ounce, distil it in a glass still according to art.\" The simples are most of them appropriated to the heart, and in truth the composition greatly nourishes and strengthens such as are in consumptions, and restores lost strength, either by fevers or other sickness: It is a sovereign remedy for hectic fevers, and Marasmos, which is nothing else but a consumption coming from them. Let such as are subject to these diseases, hold it for a jewel. (Nicholas Culpeper (1616-54) The Complete Herbal, 1850.)"},{"key":"ref_16","article-title":"The chief end of composing. this medicine, was to strengthen the heart and resist infection, and therefore is very wholesome in pestilential times, and for such as walk in stinking air","volume":"1850","unstructured":"The chief end of composing. this medicine, was to strengthen the heart and resist infection, and therefore is very wholesome in pestilential times, and for such as walk in stinking air. 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