{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:55:13Z","timestamp":1765320913834,"version":"3.46.0"},"reference-count":18,"publisher":"BMJ","issue":"6399","license":[{"start":{"date-parts":[[1983,10,15]],"date-time":"1983-10-15T00:00:00Z","timestamp":435024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,10,15]]},"abstract":"<jats:p>Sulphasalazine was first formulated by Svartz in the early 1940s, specifically for use as a remission inducing drug in rheumatoid arthritis. After the publication of an unfavourable trial, however, the drug was restricted to patients with ulcerative colitis. In the late 1970s sulphasalazine was re-examined in rheumatoid arthritis and favourable results reported in \"open\" trials. A double blind controlled trial was therefore conducted comparing enteric coated sulphasalazine and D-penicillamine in patients with active rheumatoid arthritis. A total of 63 patients were recruited in two centres; 31 were treated with sulphasalazine and 32 received penicillamine. After 16 weeks' treatment both drugs had produced significant improvements in clinical score, pain score measured on a visual analogue scale, grip strength, Ritchie articular index, erythrocyte sedimentation rate, and serum C reactive protein concentration. Nausea was the major side effect in the sulphasalazine treated group. No potentially dangerous effects of sulphasalazine were encountered in contrast with those seen in the penicillamine group. The results suggest that sulphasalazine is an effective and safe drug capable of producing remissions in active rheumatoid arthritis. They also lend confidence to the use of preliminary \"open\" trials as a means of screening for remission inducing drugs in rheumatoid arthritis.<\/jats:p>","DOI":"10.1136\/bmj.287.6399.1099","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1099-1102","source":"Crossref","is-referenced-by-count":90,"title":["Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial."],"prefix":"10.1136","volume":"287","author":[{"given":"V C","family":"Neumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Grindulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hubball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"McConkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,10,15]]},"reference":[{"key":"ref_1","first-page":"577","article-title":"a new sulfanilamide preparation","volume":"110","author":"Salazopyrin, Svartz N.","year":"1942","unstructured":"Svartz N. Salazopyrin, a new sulfanilamide preparation. Acta Med Scand 1942;110:577-98.","journal-title":"Acta Med Scand"},{"key":"ref_2","first-page":"15","volume":"287","author":"MEDICAL, B.R.I.T.I.S.H.","year":"1983","unstructured":"BRITISH MEDICAL JOURNAL VOLUME 287 15 OCTOBER 1983","journal-title":"JOURNAL VOLUME"},{"key":"ref_3","first-page":"180","article-title":"The treatment of rheumatic polyarthritis with acid azo compounds","volume":"4","author":"Svartz, N.","year":"1948","unstructured":"Svartz N. The treatment of rheumatic polyarthritis with acid azo compounds. Rheumatism 1948;4:180-6.","journal-title":"Rheumatism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/ard.8.3.226","article-title":"Salazopyrin in the treatment of rheumatoid arthritis","volume":"8","author":"Sinclair, R.J.G.; Duthie, J.J.R.","year":"1948","unstructured":"Sinclair RJG, Duthie JJR. Salazopyrin in the treatment of rheumatoid arthritis. Ann Rheum Dis 1948;8:226-31.","journal-title":"Ann Rheum Dis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF01968673","article-title":"Salazopyrin in rheumatoid arthritis","volume":"8","author":"McConkey, B.; Amos, R.S.; Butler, E.P.; Crockson, R.A.; Crockson, A.P.; Walsh, L.","year":"1978","unstructured":"McConkey B, Amos RS, Butler EP, Crockson RA, Crockson AP, Walsh L. Salazopyrin in rheumatoid arthritis. Agents Actions 1978;8:438-41.","journal-title":"Agents Actions"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/bmj.280.6212.442","article-title":"Sulphasalazine in rheumatoid arthritis","volume":"280","author":"McConkey, B.; Amos, R.S.; Durham, S.; Forster, P.J.G.; Hubball, S.; Walsh, L.","year":"1980","unstructured":"McConkey B, Amos RS, Durham S, Forster PJG, Hubball S, Walsh L. Sulphasalazine in rheumatoid arthritis. Br MedJ 1980;280:442-4.","journal-title":"Br MedJ"},{"key":"ref_7","first-page":"36","volume":"9","author":"Rheumatol","year":"1982","unstructured":"Rheumatol 1982;9:36-45."},{"key":"ref_8","first-page":"115","article-title":"The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants","volume":"162","author":"McConkey, B.; Crockson, R.A.; Crockson, A.P.","year":"1972","unstructured":"McConkey B, Crockson RA, Crockson AP. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. QJ Med 1972;162:115-25.","journal-title":"QJ Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/rheumatology\/15.3.230","article-title":"Dapsone in rheumatoid arthritis","volume":"15","author":"McConkey, B.; Davies, P.; Crockson, R.A.; Crockson, A.P.; Butler, M.; Constable, T.J.","year":"1976","unstructured":"McConkey B, Davies P, Crockson RA, Crockson AP, Butler M, Constable TJ. Dapsone in rheumatoid arthritis. Rheumatol Rehabil 1976;15:230-4.","journal-title":"Rheumatol Rehabil"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/ard.40.3.235","article-title":"Double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis","volume":"40","author":"Swinson, D.R.; Zlosnick, J.; Jackson, L.","year":"1981","unstructured":"Swinson DR, Zlosnick J, Jackson L. Double-blind trial of dapsone against placebo in the treatment of rheumatoid arthritis. Ann Rheum Dis 1981; 40:235-9.","journal-title":"Ann Rheum Dis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/ard.39.1.18","article-title":"Rheumatoid arthritis: effects of a new agent (ICI 55,897) on serum acute phase proteins and the erythrocyte sedimentation rate","volume":"39","author":"McConkey, B.; Amos, R.S.; Billingham, M.E.J.; Constable, T.J.; Crockson, R.A.; Forster, P.J.G.","year":"1980","unstructured":"McConkey B, Amos RS, Billingham MEJ, Constable TJ, Crockson RA, Forster PJG. Rheumatoid arthritis: effects of a new agent (ICI 55,897) on serum acute phase proteins and the erythrocyte sedimentation rate. Ann Rheum Dis 1980;39:18-21.","journal-title":"Ann Rheum Dis"},{"key":"ref_12","first-page":"149","article-title":"Clozic-a new slow-acting agent in rheumatoid arthritis. In: Therapeutic workshops, communications and panels. XV ILAR international congress of rheumatology","author":"Davies, J.; Bacon, P.A.; Hall, N.D.; Ring, E.F.J.","year":"1981","unstructured":"Davies J, Bacon PA, Hall ND, Ring EFJ. Clozic-a new slow-acting agent in rheumatoid arthritis. In: Therapeutic workshops, communications and panels. XV ILAR international congress of rheumatology, Paris, 1981. Paris: Expansion Scientifique Francaise, 1982. (Abstract 301: p 149.)","journal-title":"Paris: Expansion Scientifique Francaise"},{"key":"ref_13","first-page":"195","article-title":"Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes","volume":"i:","author":"Amos, R.S.; Constable, T.J.; Crockson, R.A.; Crockson, A.P.; McConkey, B.","year":"1977","unstructured":"Amos RS, Constable TJ, Crockson RA, Crockson AP, McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br MedJ 1977;i:195-7.","journal-title":"Br MedJ"},{"key":"ref_14","first-page":"226","article-title":"Assessment of x ray progression in a controlled therapeutic study using a new visual analogue scoring system","volume":"42","author":"Rushton, A.; Bird, H.A.; Wright, V.","year":"1983","unstructured":"Rushton A, Bird HA, Wright V. Assessment of x ray progression in a controlled therapeutic study using a new visual analogue scoring system. Ann Rheum Dis 1983;42:226.","journal-title":"Ann Rheum Dis"},{"key":"ref_15","first-page":"226","article-title":"Radiological progression in rheumatoid arthritis","volume":"42","author":"Scott, D.L.; Grindulis, K.A.; Struthers, G.R.; Coulton, B.L.; Popert, A.J.; Bacon, P.A.","year":"1983","unstructured":"Scott DL, Grindulis KA, Struthers GR, Coulton BL, Popert AJ, Bacon PA. Radiological progression in rheumatoid arthritis. Ann Rheum Dis 1983;42:226-7.","journal-title":"Ann Rheum Dis"},{"key":"ref_16","first-page":"276","article-title":"Male infertility due to sulphasalazine","volume":"ii:","author":"Levi, A.J.; Fisher, A.M.; Hughes, L.; Hendry, W.F.","year":"1979","unstructured":"Levi AJ, Fisher AM, Hughes L, Hendry WF. Male infertility due to sulphasalazine. Lancet 1979;ii:276-8.","journal-title":"Lancet"},{"article-title":"Accepted 1 Jrune","year":"1983","key":"ref_17","unstructured":"(Accepted 1 Jrune 1983)"},{"key":"ref_18","unstructured":"Sulphasalazine (4-pyridyl -(2)-aminosulphonyl - 3-carboxy -4hydrobenzol) was introduced by Svartz in 1942 for the treatment of rheumatoid arthritis and ulcerative colitis.1 Despite further promising studies2 3the drug fell out of favour for the treatment of rheumatoid arthritis after the publication of Sinclair and Duthie's paper in 1948.4 It was not until 30 years later that McConkey et al reported an open study of sulphasalazine in the treatment of rheumatoid arthritis,5 6 and interest has again developed in the use of the drug for this condition. Bird et al recently screened the drug for \"second line\" properties and found it to have such qualities.7","article-title":"Sulphasalazine (4-pyridyl -(2)-aminosulphonyl - 3-carboxy -4hydrobenzol) was introduced by Svartz in 1942 for the treatment of rheumatoid arthritis and ulcerative colitis.1 Despite further promising studies2 3the drug fell out of favour for the treatment of rheumatoid arthritis after the publication of Sinclair and Duthie's paper in 1948.4 It was not until 30 years later that McConkey et al reported an open study of sulphasalazine in the treatment of rheumatoid arthritis,5 6 and interest has again developed in the use of the drug for this condition. Bird et al recently screened the drug for \"second line\" properties and found it to have such qualities.7"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.287.6399.1099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.287.6399.1099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:45:53Z","timestamp":1765320353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.287.6399.1099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10,15]]},"references-count":18,"journal-issue":{"issue":"6399","published-online":{"date-parts":[[1983,10,15]]},"published-print":{"date-parts":[[1983,10,15]]}},"alternative-id":["10.1136\/bmj.287.6399.1099"],"URL":"https:\/\/doi.org\/10.1136\/bmj.287.6399.1099","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,10,15]]}}}