{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:13:23Z","timestamp":1766391203436,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"6400","license":[{"start":{"date-parts":[[1983,10,22]],"date-time":"1983-10-22T00:00:00Z","timestamp":435628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,10,22]]},"abstract":"<jats:p>Astemizole and terfenadine, two potent non-sedative H1 antihistamines, had no effect on itch measured objectively as nocturnal scratching and subjectively on a 10 cm line. Trimeprazine, however, a more sedative but less potent H1 antihistamine, was antipruritic, as was nitrazepam, a sedative benzodiazepine. We concluded (a) that antipruritic drugs act centrally by a property related to sedation; (b) H1 receptor antagonists have a peripheral antipruritic action only when itch is due to histamine release, as in the wealing disorders. Thus the new nonsedative H1 antihistamines have no place in the treatment of itch from other causes.<\/jats:p>","DOI":"10.1136\/bmj.287.6400.1199","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1199-1200","source":"Crossref","is-referenced-by-count":128,"title":["Mechanism of action of antipruritic drugs."],"prefix":"10.1136","volume":"287","author":[{"given":"L","family":"Krause","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,10,22]]},"reference":[{"key":"ref_1","first-page":"283","article-title":"Differential effect of hypnotics and anxiolytics on itch and scratch","volume":"72","author":"Muston, H.; Felix, R.; Shuster, S.","year":"1979","unstructured":"Muston H, Felix R, Shuster S. Differential effect of hypnotics and anxiolytics on itch and scratch. ] Invest Dermatol 1979;72:283.","journal-title":"Invest Dermatol"},{"key":"ref_2","series-title":"Proceedings of the Royal Institution of Great Britain","first-page":"136","article-title":"Reason and the rash","volume":"53","author":"Shuster, S.","year":"1981","unstructured":"Shuster S. Reason and the rash. Proceedings of the Royal Institution of Great Britain 1981;53:136-63."},{"key":"ref_3","first-page":"303","article-title":"A new method for the measurement of itch and the response to treatment","volume":"93","author":"Felix, R.; Shuster, S.","year":"1975","unstructured":"Felix R, Shuster S. A new method for the measurement of itch and the response to treatment. Br]7 Dermatol 1975;93:303-12."},{"key":"ref_4","first-page":"106","article-title":"Measurement of itch. In: Mechanisms of topical corticoid activity","author":"Felix, R.; Shuster, S.","year":"1975","unstructured":"Felix R, Shuster S. Measurement of itch. In: Mechanisms of topical corticoid activity. London: Churchill Livingstone, 1975:106-13."},{"key":"ref_5","first-page":"275","article-title":"The measurement of itch with sensitive limb movement meters","volume":"102","author":"Summerfield, J.A.; Welch, M.E.","year":"1980","unstructured":"Summerfield JA, Welch ME. The measurement of itch with sensitive limb movement meters. Br]7 Dermatol 1980;102:275-81."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2125.1982.tb01356.x","article-title":"Performance studies with the H5 histamine receptor antagonists, astemizole and terfenadine","volume":"13","author":"Nicholson, A.N.; Stone, B.M.","year":"1982","unstructured":"Nicholson AN, Stone BM. Performance studies with the H5 histamine receptor antagonists, astemizole and terfenadine. Br J Clin Pharmacol 1982;13:199-202.","journal-title":"Br J Clin Pharmacol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00609860","article-title":"Inhibitory activity of terfenadine on histamine-induced skin wheals in man","volume":"12","author":"Huther, K.J.; Renftle, G.; Barraud, N.; Burke, J.T.; Koch-Weser, J.","year":"1977","unstructured":"Huther KJ, Renftle G, Barraud N, Burke JT, Koch-Weser J. Inhibitory activity of terfenadine on histamine-induced skin wheals in man. Eur] Clin Pharmacol 1977;12:195-9.","journal-title":"Eur] Clin Pharmacol"},{"key":"ref_8","first-page":"245","article-title":"Chronopharmacological study of antihistamines in man with special reference to terfenadine. Eur]7 Clin","volume":"14","author":"Reinberg, A.; Levi, F.; Guillet, P.; Burke, J.T.; Nicolai, A.","year":"1978","unstructured":"Reinberg A, Levi F, Guillet P, Burke JT, Nicolai A. Chronopharmacological study of antihistamines in man with special reference to terfenadine. Eur]7 Clin Pharmacol 1978;14:245-52.","journal-title":"Pharmacol"},{"article-title":"The effect of terfenadine on dermographic wealing","author":"Krause, L.; Shuster, S.","key":"ref_9","unstructured":"Krause L, Shuster S. The effect of terfenadine on dermographic wealing. Br 7 Dermatol (in press)."},{"author":"Accepted 277uly 1983)","key":"ref_10","unstructured":"(Accepted 277uly 1983)"},{"key":"ref_11","first-page":"431","article-title":"Neuropharmacological agents modifying endotoxininduced changes in mice.7 R","volume":"73","author":"Wright, D.J.M.; Weller, M.P.I.","year":"1980","unstructured":"Wright DJM, Weller MPI. Neuropharmacological agents modifying endotoxininduced changes in mice.7 R Soc Med 1980;73:431-6.","journal-title":"Soc Med"},{"key":"ref_12","first-page":"326","article-title":"Effects of naloxone in hemorrhagic shock","volume":"155","author":"Albert, S.A.; Shires GT, III, Illner; H, Shires; G.T.","year":"1982","unstructured":"Albert SA, Shires GT III, Illner H, Shires GT. Effects of naloxone in hemorrhagic shock. Surg Gynecol Obstet 1982;155:326-32.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_13","first-page":"1360","volume":"ii:","author":"Kirksen, R.; Otten, M.H.; Wood, G.J.","year":"1980","unstructured":"Kirksen R, Otten MH, Wood GJ, et al. Naloxone in shock. Lancet 1980;ii:1360-1.","journal-title":"Naloxone in shock. Lancet"},{"key":"ref_14","article-title":"Heredity and environment in the functional psychoses","author":"Kringlen, E.","year":"1967","unstructured":"Kringlen E. Heredity and environment in the functional psychoses. Loridon: Heinemann, 1967."},{"key":"ref_15","article-title":"A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses","volume":"194","author":"Perris, C.","year":"1966","unstructured":"Perris C. A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiat Neuzrol Scand 1966; suppl 194.","journal-title":"Acta Psychiat Neuzrol Scand"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.287.6400.1199","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.287.6400.1199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:50:08Z","timestamp":1765320608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.287.6400.1199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10,22]]},"references-count":15,"journal-issue":{"issue":"6400","published-online":{"date-parts":[[1983,10,22]]},"published-print":{"date-parts":[[1983,10,22]]}},"alternative-id":["10.1136\/bmj.287.6400.1199"],"URL":"https:\/\/doi.org\/10.1136\/bmj.287.6400.1199","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,10,22]]}}}