{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:36:33Z","timestamp":1765395393650,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"6413","license":[{"start":{"date-parts":[[1984,1,28]],"date-time":"1984-01-28T00:00:00Z","timestamp":444096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,1,28]]},"abstract":"<jats:p>A consecutive series of 791 women who had attended diagnostic breast clinics during 1967-70 and been found to be free of malignant disease were later traced to determine their subsequent incidence of breast cancer. Of the 770 (97%) successfully traced, 22 had developed breast cancer. Based on data from the Welsh Cancer Registry only eight cases of breast cancer had been expected, so that the excess risk for the group was 2.7. The increased risk occurred in all age groups and in women deemed \"essentially normal\" as well as in those who had had a pathological abnormality. The risk was increased when epithelial hyperplasia was present. No excess mortality from breast cancer was apparent, but follow up was short. More breast symptoms were experienced and more biopsies performed than expected in this group of women. Women with a past history of benign breast disease have a slightly increased risk of breast cancer. Selective screening of these women, however, may be uneconomic and a cause of groundless anxiety.<\/jats:p>","DOI":"10.1136\/bmj.288.6413.275","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"275-278","source":"Crossref","is-referenced-by-count":61,"title":["Risk of breast cancer in women with history of benign disease of the breast."],"prefix":"10.1136","volume":"288","author":[{"given":"M M","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Elton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Fortt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I H","family":"Gravelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/1097-0142(196408)17:8<957::AID-CNCR2820170802>3.0.CO;2-O","article-title":"Cystic disease of the breast: relationship to carcinoma","volume":"17","author":"HH, I.Davies; M, Simons; JB, Davies","year":"1964","unstructured":"I Davies HH, Simons M, Davies JB. Cystic disease of the breast: relationship to carcinoma. Cancer 1964;17:957-78.","journal-title":"Cancer"},{"key":"ref_2","first-page":"529","article-title":"Breast cancer in women subsequent to cystic disease of the breast","volume":"126","author":"Veronesi, U.; Pizzocaro, G.","year":"1968","unstructured":"Veronesi U, Pizzocaro G. Breast cancer in women subsequent to cystic disease of the breast. Surg Gynecol Obstet 1968;126:529-32.","journal-title":"Surg Gynecol Obstet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(76)91026-6","article-title":"Chronic mastitis and carcinoma of the breast","volume":"ii:","author":"Monson, R.R.; Yen, S.; MacMahon, B.","year":"1976","unstructured":"Monson RR, Yen S, MacMahon B. Chronic mastitis and carcinoma of the breast. Lancet 1976;ii:224-6.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/1097-0142(197706)39:6<2603::AID-CNCR2820390645>3.0.CO;2-T","article-title":"Chronic mastopathy and breast cancer","volume":"39","author":"Kodlin, D.; Winger, E.E.; Morgenstern, N.L.; Chen, U.","year":"1977","unstructured":"Kodlin D, Winger EE, Morgenstern NL, Chen U. Chronic mastopathy and breast cancer. Cancer 1977;39:2603-7.","journal-title":"Cancer"},{"key":"ref_5","first-page":"1055","article-title":"Relation between component parts of fibrocystic disease complex and breast cancer","volume":"61","author":"Page, D.L.; Vander Zwaag, R.; Rogers, N.W.","year":"1978","unstructured":"Page DL, Vander Zwaag R, Rogers NW, et al. Relation between component parts of fibrocystic disease complex and breast cancer. Jfournal of the National Cancer Institute 1978;61:1055-64.","journal-title":"Jfournal of the National Cancer Institute"},{"key":"ref_6","first-page":"13","article-title":"Risk of breast cancer in women with benign breast disease","volume":"65","author":"Hutchinson, W.B.; Thomas, D.B.; Hablin, W.B.","year":"1980","unstructured":"Hutchinson WB, Thomas DB, Hablin WB, et al. Risk of breast cancer in women with benign breast disease. J'ournal of the National Cancer Institute 1980;65:13-20.","journal-title":"J'ournal of the National Cancer Institute"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0091-7435(79)90028-8","article-title":"A prospective study of the relationship between benign breast diseases and breast carcinoma","volume":"8","author":"Coombs, L.J.; Lilienfeld, A.M.","year":"1979","unstructured":"Coombs LJ, Lilienfeld AM. A prospective study of the relationship between benign breast diseases and breast carcinoma. Prev Med 1979;8: 40-52.","journal-title":"Prev Med"},{"key":"ref_8","first-page":"70","article-title":"Breast carcinoma risk and detection","author":"Haagenson, C.D.; Bodian, C.; Haagenson, D.E.","year":"1981","unstructured":"Haagenson CD, Bodian C, Haagenson DE. Breast carcinoma risk and detection. Philadelphia: WB Saunders Co, 1981:70-4."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jech.37.2.127","article-title":"Risk factors for breast cancer: relevance to screening","volume":"37","author":"Duffy, S.W.; Roberts, M.M.; Elton, R.A.","year":"1983","unstructured":"Duffy SW, Roberts MM, Elton RA. Risk factors for breast cancer: relevance to screening. J Epidemiol Community Health 1983;37:127-31.","journal-title":"J Epidemiol Community Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.2105\/AJPH.58.5.820","article-title":"The search for risk factors in breast cancer","volume":"58","author":"Shapiro, S.; Strax, P.; Venet, L.; Fink, R.","year":"1968","unstructured":"Shapiro S, Strax P, Venet L, Fink R. The search for risk factors in breast cancer. Am Public Health 1968;58:820-35.","journal-title":"Am Public Health"},{"key":"ref_11","first-page":"211","article-title":"Risk factors for breast cancer in women in Northern Alberta, Canada, as related to age at diagnosis","volume":"68","author":"Lubin, J.H.; Burns, P.E.; Blot, W.J.","year":"1982","unstructured":"Lubin JH, Burns PE, Blot WJ, et al. Risk factors for breast cancer in women in Northern Alberta, Canada, as related to age at diagnosis. J'ournal of the National Cancer Institute 1982;68:211-7.","journal-title":"J'ournal of the National Cancer Institute"},{"key":"ref_12","first-page":"1755","article-title":"An epidemiological study of oral contraceptives and breast cancer. Br MedJ'","volume":"i:","author":"Vessey, M.P.; Doll, R.; Jones, K.; McPherson, K.; Yeates, D.","year":"1979","unstructured":"Vessey MP, Doll R, Jones K, McPherson K, Yeates D. An epidemiological study of oral contraceptives and breast cancer. Br MedJ' 1979;i:1755-8."},{"key":"ref_13","first-page":"12","article-title":"Characteristics that predict risk of breast cancer before and after the menopause","volume":"1","author":"Paffenbarger, R.S.; Kampert, J.B.; Chang, H.G.","year":"1980","unstructured":"Paffenbarger RS, Kampert JB, Chang HG. Characteristics that predict risk of breast cancer before and after the menopause. Am J Epidemiol 1980;1 12:258-68.","journal-title":"Am J Epidemiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/1097-0142(197806)41:6<2341::AID-CNCR2820410637>3.0.CO;2-N","article-title":"The epidemiology of breast cancer in 785 US Caucasian women","volume":"41","author":"Wynder, E.L.; MacCormack, F.A.; Stellman, S.D.","year":"1978","unstructured":"Wynder EL, MacCormack FA, Stellman SD. The epidemiology of breast cancer in 785 US Caucasian women. Cancer 1978;41:2341-54.","journal-title":"Cancer"},{"key":"ref_15","first-page":"37","article-title":"Breast cancer risk factors among screening programme participants","volume":"62","author":"Brinton, L.A.; Williams, R.R.; Hoover, R.N.","year":"1979","unstructured":"Brinton LA, Williams RR, Hoover RN, et al. Breast cancer risk factors among screening programme participants. J7ournal of the National Cancer Institute 1979;62:37-44."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/bjc.1981.246","article-title":"Trial of early detection of breast cancer","volume":"44","author":"Chamberlain, J.","year":"1981","unstructured":"Chamberlain J. Trial of early detection of breast cancer. Br J Cancer 1981;44:618-27.","journal-title":"Br J Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0140-6736(73)92287-3","article-title":"Importance of a high tracing rate in long-term medical follow-up studies","volume":"ii:","author":"Sims, A.C.P.","year":"1973","unstructured":"Sims ACP. Importance of a high tracing rate in long-term medical follow-up studies. Lancet 1973;ii:433-5.","journal-title":"Lancet"},{"key":"ref_18","first-page":"231","article-title":"An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions","volume":"55","author":"Wellings, SR, Jensen; HM, Marcum; R.G.","year":"1975","unstructured":"Wellings SR, Jensen HM, Marcum RG. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. Journal of the National Cancer Institute 1975;55:231-73.","journal-title":"Journal of the National Cancer Institute"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/1097-0142(197605)37:5<2486::AID-CNCR2820370542>3.0.CO;2-8","article-title":"Risk for breast cancer development determined by mammographic parenchymal patterns","volume":"37","author":"Wolfe, J.","year":"1976","unstructured":"Wolfe J. Risk for breast cancer development determined by mammographic parenchymal patterns. Cancer 1976;37:2486-92.","journal-title":"Cancer"},{"key":"ref_20","first-page":"18","article-title":"Population Censuses and Surveys. Report of the Advisory Committee on Cancer Registration, England and Wales","author":"Office of","year":"1980","unstructured":"Office of Population Censuses and Surveys. Report of the Advisory Committee on Cancer Registration, England and Wales. London: OPCS, 1980:18-22."},{"key":"ref_21","first-page":"731","article-title":"Mortality among women participating in the Oxford\/Family Planning Association contraceptive study","volume":"ii:","author":"Vessey, M.P.; McPherson, K.; Johnson, B.","year":"1977","unstructured":"Vessey MP, McPherson K, Johnson B. Mortality among women participating in the Oxford\/Family Planning Association contraceptive study. Lancet 1977;ii:731-3.","journal-title":"Lancet"},{"key":"ref_22","first-page":"365","article-title":"The management of locally advanced breast cancer by x ray therapy","volume":"2","author":"Langlands, A.O.; Kerr, G.R.; Shaw, S.","year":"1976","unstructured":"Langlands AO, Kerr GR, Shaw S. The management of locally advanced breast cancer by x ray therapy. Clin Oncol 1976;2:365-71.","journal-title":"Clin Oncol"},{"key":"ref_23","first-page":"112","article-title":"Incidence rates and risk factors of benign breast neoplasms","volume":"108","author":"Cole, P.; Elwood, J.M.; Kaplan, S.D.","year":"1978","unstructured":"Cole P, Elwood JM, Kaplan SD. Incidence rates and risk factors of benign breast neoplasms. AmJ7 Epidemiol 1978;108:112-20."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1056\/NEJM198210143071611","article-title":"Fibrocystic \"disease\" of the breastnon-disease ?","volume":"307","author":"Love, S.M.; Gelman, R.S.; Silen, W.","year":"1982","unstructured":"Love SM, Gelman RS, Silen W. Fibrocystic \"disease\" of the breastnon-disease ? N EnglJl Med 1982;307:1010-4.","journal-title":"N EnglJl Med"},{"article-title":"Accepted 27","year":"1983","key":"ref_25","unstructured":"(Accepted 27 October 1983)"},{"key":"ref_26","unstructured":"From January 1977 to December 1981 all patients under the care of NAM and undergoing an abdominal operation were included.","article-title":"From January 1977 to December 1981 all patients under the care of NAM and undergoing an abdominal operation were included"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6413.275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6413.275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:33:28Z","timestamp":1765395208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6413.275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1,28]]},"references-count":26,"journal-issue":{"issue":"6413","published-online":{"date-parts":[[1984,1,28]]},"published-print":{"date-parts":[[1984,1,28]]}},"alternative-id":["10.1136\/bmj.288.6413.275"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6413.275","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,1,28]]}}}