{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:06:57Z","timestamp":1765397217468,"version":"3.46.0"},"reference-count":19,"publisher":"BMJ","issue":"6418","license":[{"start":{"date-parts":[[1984,3,3]],"date-time":"1984-03-03T00:00:00Z","timestamp":447120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,3,3]]},"abstract":"<jats:p>Patients with subnormal serum vitamin B12 concentrations were tested for absorption of protein bound vitamin B12 and compared with controls. Absorption of the protein bound vitamin appeared to decrease with increasing age in healthy subjects. Differences between the result of this test and the result of the Schilling test in patients who had undergone gastric surgery were confirmed; such differences were also seen in some patients who had iron deficiency anaemia, an excessive alcohol intake, or folate deficiency. Defective absorption was also found in six patients with an adequate dietary intake of vitamin B12, normal Schilling test results, low serum vitamin concentrations, and tissue changes responding to treatment with vitamin B12. Malabsorption of the vitamin from protein bound sources, which is not detected by the Schilling test, may produce vitamin B12 deficiency of clinical importance.<\/jats:p>","DOI":"10.1136\/bmj.288.6418.675","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"675-678","source":"Crossref","is-referenced-by-count":59,"title":["Malabsorption of protein bound vitamin B12."],"prefix":"10.1136","volume":"288","author":[{"given":"D W","family":"Dawson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A H","family":"Sawers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R K","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,3,3]]},"reference":[{"key":"ref_1","first-page":"860","article-title":"Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12","volume":"42","author":"Schilling, R.F.","year":"1953","unstructured":"Schilling RF. Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med 1953;42:860-6.","journal-title":"J Lab Clin Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1001\/jama.1971.03180330043007","article-title":"Vitamin B12 absorption tests. Their unreliability in postgastrectomy states","volume":"216","author":"Mahmud, K.; Ripley, D.; Doscherholmen, A.","year":"1971","unstructured":"Mahmud K, Ripley D, Doscherholmen A. Vitamin B12 absorption tests. Their unreliability in postgastrectomy states.JAMA 1971;216:1167-71.","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2141.1976.tb03537.x","article-title":"Inhibitory effect of eggs on vitamin B12 absorption: description of a simple ovalbumin 57Co-vitamin B12 absorption test","volume":"33","author":"Doscherholmen, A.; McMahon, J.; Ripley, D.","year":"1976","unstructured":"Doscherholmen A, McMahon J, Ripley D. Inhibitory effect of eggs on vitamin B12 absorption: description of a simple ovalbumin 57Co-vitamin B12 absorption test. 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Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administration. Dig Dis Sci 1980;25:188-92.","journal-title":"Dig Dis Sci"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF01297127","article-title":"Clinically significant vitamin B12 deficiency secondary to malabsorption of protein-bound vitamin B12","volume":"24","author":"King, C.E.; Leibach, J.; Toskes, P.P.","year":"1979","unstructured":"King CE, Leibach J, Toskes PP. Clinically significant vitamin B12 deficiency secondary to malabsorption of protein-bound vitamin B12. Dig Dis Sci 1979;24:397-402.","journal-title":"Dig Dis Sci"},{"key":"ref_9","first-page":"378","article-title":"The megaloblastic anaemias","author":"Chanarin, I.","year":"1979","unstructured":"Chanarin I. The megaloblastic anaemias. 2nd ed. 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Lancet 1983;i:1104-5.","journal-title":"Lancet"},{"article-title":"Accepted","year":"1983","key":"ref_19","unstructured":"(Accepted 9 December 1983)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6418.675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6418.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:04:14Z","timestamp":1765397054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6418.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3,3]]},"references-count":19,"journal-issue":{"issue":"6418","published-online":{"date-parts":[[1984,3,3]]},"published-print":{"date-parts":[[1984,3,3]]}},"alternative-id":["10.1136\/bmj.288.6418.675"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6418.675","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,3,3]]}}}