{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:16:53Z","timestamp":1765397813641,"version":"3.46.0"},"reference-count":8,"publisher":"BMJ","issue":"6420","license":[{"start":{"date-parts":[[1984,3,17]],"date-time":"1984-03-17T00:00:00Z","timestamp":448329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,3,17]]},"abstract":"<jats:p>Treatment of idiopathic orthostatic hypotension is often unsatisfactory. A patient with the Shy-Drager syndrome, in which the most important symptom is orthostatic hypotension, was treated with prenalterol, initially 30 mg six times daily. The dosage was reduced to 30 mg four times daily because of the development of complex ventricular premature beats. Orthostatic symptoms were reduced and standing blood pressure increased. Fludrocortisone 0.5 mg a day was added to treatment with further improvement. This clinical effect was maintained throughout 12 months of follow up, during which the treatment was continued unchanged. Prenalterol was effective in reducing orthostatic symptoms in this patient. Further studies in patients with a similar haemodynamic pattern are indicated.<\/jats:p>","DOI":"10.1136\/bmj.288.6420.817","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"817-818","source":"Crossref","is-referenced-by-count":4,"title":["Effect of prenalterol on orthostatic hypotension in the Shy-Drager syndrome."],"prefix":"10.1136","volume":"288","author":[{"given":"J","family":"Goovaerts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Verfaillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Fagard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Knockaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,3,17]]},"reference":[{"key":"ref_1","first-page":"1151","article-title":"Current management concepts in orthostatic hypotension","volume":"140","author":"IJ, I.Schatz","year":"1980","unstructured":"I Schatz IJ. Current management concepts in orthostatic hypotension. Arch Int Med 1980;140:1151-4.","journal-title":"Arch Int Med"},{"key":"ref_2","first-page":"1","article-title":"Pharmacological and clinical effects of prenalterol-a new inotropic beta-adrenoceptor stimulant","volume":"659","author":"Ablad, B.; Hjalmarson, A.; Johnsson, G.","year":"1980","unstructured":"Ablad B, Hjalmarson A, Johnsson G. Pharmacological and clinical effects of prenalterol-a new inotropic beta-adrenoceptor stimulant. Proceedings of the symposium in Hamburg, December 5, 1980. Acta Med Scand 1982;suppl 659:1-325.","journal-title":"Proceedings of the symposium in Hamburg; Acta Med Scand"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/brain\/102.1.163","article-title":"Defective cardiovascular reflexes and supersensitivity to sympathomimetic drugs in autonomic failure","volume":"102","author":"Bannister, R.; Davies, B.; Holly, E.; Rosenthal, T.; Sever, P.","year":"1979","unstructured":"Bannister R, Davies B, Holly E, Rosenthal T, Sever P. Defective cardiovascular reflexes and supersensitivity to sympathomimetic drugs in autonomic failure. Brain 1979;102:163-76.","journal-title":"Brain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.CIR.65.1.99","article-title":"Non-invasive determination of left ventricular end-systolic stress, validation of the method and initial application","volume":"65","author":"Reichek, N.; Wilson, J.; Sutton, M.; Plappert, T.A.; Goldberg, G.; Hirshfeld, J.W.","year":"1982","unstructured":"Reichek N, Wilson J, Sutton M, Plappert TA, Goldberg G, Hirshfeld JW. Non-invasive determination of left ventricular end-systolic stress, validation of the method and initial application. Circulation 1982;65: 99-108.","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJM198006263022606","article-title":"Atrial tachypacing in the treatment of a patient with primary orthostatic hypotension","volume":"302","author":"Moss, A.J.; Glasser, W.; Topol, E.","year":"1980","unstructured":"Moss AJ, Glasser W, Topol E. Atrial tachypacing in the treatment of a patient with primary orthostatic hypotension. N Engl.7 Med 1980; 302:1456-7.","journal-title":"N Engl.7 Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/bmj.282.6268.929","article-title":"Man in 't Veld AJ, Schalekamp MADH. Pindolol acts as beta-adrenoceptor agonist in orthostatic hypotension: therapeutic implications","volume":"282","year":"1981","unstructured":"Man in 't Veld AJ, Schalekamp MADH. Pindolol acts as beta-adrenoceptor agonist in orthostatic hypotension: therapeutic implications. Br Med J 1981;282:929-31.","journal-title":"Br Med J"},{"key":"ref_7","first-page":"982","article-title":"Pindolol in postural hypotension, the case for caution","volume":"ii:","author":"Davies, B.; Bannister, R.; Mathias, C.; Sever, P.","year":"1981","unstructured":"Davies B, Bannister R, Mathias C, Sever P. Pindolol in postural hypotension, the case for caution. Lancet 1981;ii:982-3.","journal-title":"Lancet"},{"author":"Accepted 10_January 1984)","key":"ref_8","unstructured":"(Accepted 10_January 1984)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6420.817","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6420.817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:15:12Z","timestamp":1765397712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6420.817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3,17]]},"references-count":8,"journal-issue":{"issue":"6420","published-online":{"date-parts":[[1984,3,17]]},"published-print":{"date-parts":[[1984,3,17]]}},"alternative-id":["10.1136\/bmj.288.6420.817"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6420.817","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,3,17]]}}}