{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:37:13Z","timestamp":1765399033180,"version":"3.46.0"},"reference-count":10,"publisher":"BMJ","issue":"6422","license":[{"start":{"date-parts":[[1984,3,31]],"date-time":"1984-03-31T00:00:00Z","timestamp":449539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,3,31]]},"abstract":"<jats:p>Endometrial aspiration cytology has been shown by multicentre prospective studies to be an acceptable and valuable method of assessing the endometrium. A retrospective study was undertaken over three years' routine use of the Isaacs cell sampler. In 86% of the cases suitable endometrium was obtained, with experience of the technique being the important factor. When compared with histological findings, all 11 cases of malignancy were confirmed, including one ovarian adenocarcinoma. Of the cytological reports of endometrial hyperplasia, 78% were confirmed by the histological findings, with the remainder showing minor degrees of cystic hyperplasia or normal endometrium. In no case was a more abnormal lesion present on histological examination than had been suggested by cytological findings. The use of progestogens in reversing hyperplasia is seen to be effective, though the long term benefit remains uncertain. It is concluded that with an experienced cytologist, Isaacs endometrial aspiration should be used routinely for the primary investigation of dysfunctional uterine bleeding and postmenopausal bleeding.<\/jats:p>","DOI":"10.1136\/bmj.288.6422.981","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"981-983","source":"Crossref","is-referenced-by-count":20,"title":["An alternative to the diagnostic dilatation and curettage--endometrial cytology."],"prefix":"10.1136","volume":"288","author":[{"given":"D W","family":"Polson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W","family":"Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,3,31]]},"reference":[{"key":"ref_1","first-page":"303","article-title":"l Anforaker SH, Kawada CY, McKinney D. Endometrial aspiration studies on Isaacs cell sampler with cytohistologic correlation","volume":"23","year":"1979","unstructured":"l Anforaker SH, Kawada CY, McKinney D. Endometrial aspiration studies on Isaacs cell sampler with cytohistologic correlation. Acta Cytol (Baltimore) 1979;23:303-8.","journal-title":"Acta Cytol (Baltimore)"},{"key":"ref_2","first-page":"364","article-title":"The Isaacs cell sampler. An alternative to curettage. Br MedJ3","volume":"281","author":"Segadal, E.; Iversen, O.E.","year":"1980","unstructured":"Segadal E, Iversen OE. The Isaacs cell sampler. An alternative to curettage. Br MedJ3 1980;281:364-5."},{"key":"ref_3","first-page":"947","article-title":"Endometrial assessment with Isaacs cell sampler","volume":"i:","author":"Hutton, J.D.; Morse, A.R.; Anderson, M.C.; Beard, R.W.","year":"1978","unstructured":"Hutton JD, Morse AR, Anderson MC, Beard RW. Endometrial assessment with Isaacs cell sampler. 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Am J Obstet Gynecol 1974; 118:679-87.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"ref_6","first-page":"519","article-title":"Cytologic diagnosis of endometrial carcinoma. Result of ten years'","volume":"1962","author":"Koss, L.G.; Durfee, G.R.","unstructured":"Koss LG, Durfee GR. Cytologic diagnosis of endometrial carcinoma. Result of ten years' experience. Acta Cytol (Baltimore) 1962;6: 519-31.","journal-title":"experience. Acta Cytol (Baltimore)"},{"key":"ref_7","first-page":"422","article-title":"Aspiration cytology versus histology in the assessment of the endometrium of women attending a menopause clinic","volume":"88","author":"Ellice, R.M.; Morse, A.R.; Anderson, M.C.","year":"1981","unstructured":"Ellice RM, Morse AR, Anderson MC. Aspiration cytology versus histology in the assessment of the endometrium of women attending a menopause clinic. BrJr Obstet Gynaecol 1981;88:422-5.","journal-title":"BrJr Obstet Gynaecol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9378(16)38737-3","article-title":"Cytological approach to uterine carcinoma","volume":"64","author":"Hecht, E.L.","year":"1952","unstructured":"Hecht EL. Cytological approach to uterine carcinoma. Am J Obstet Gynecol 1952;64:81-90.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0002-9378(63)90290-4","article-title":"Endometrial aspiration smear in diagnosis of malignancy of uterine corpus","volume":"87","author":"Rascoe, R.R.","year":"1963","unstructured":"Rascoe RR. Endometrial aspiration smear in diagnosis of malignancy of uterine corpus. Am3J Obstet Gynecol 1963;87:921-5.","journal-title":"Am3J Obstet Gynecol"},{"article-title":"Accepted 30","year":"1983","key":"ref_10","unstructured":"(Accepted 30 December 1983)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6422.981","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6422.981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:32:50Z","timestamp":1765398770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6422.981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3,31]]},"references-count":10,"journal-issue":{"issue":"6422","published-online":{"date-parts":[[1984,3,31]]},"published-print":{"date-parts":[[1984,3,31]]}},"alternative-id":["10.1136\/bmj.288.6422.981"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6422.981","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,3,31]]}}}