{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:37:26Z","timestamp":1770219446386,"version":"3.49.0"},"reference-count":16,"publisher":"BMJ","issue":"6429","license":[{"start":{"date-parts":[[1984,5,19]],"date-time":"1984-05-19T00:00:00Z","timestamp":453772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,5,19]]},"abstract":"<jats:p>The serum fructosamine concentration was examined as a new means to monitor metabolic control in non-insulin-dependent diabetes during changes in management. Weekly fructosamine estimations were compared with glycosylated haemoglobin (HbA1c), 24 hour urinary glucose, and fasting plasma glucose concentrations in a 17 week study entailing withdrawal and reinstitution of oral treatment. The serum fructosamine concentration was more sensitive than the other measurements in detecting a deterioration in diabetic control after stopping oral hypoglycaemic drugs. The response to reinstitution of treatment was not significant in the first three weeks (p = 0.266), despite a highly significant reduction in fasting plasma glucose (p = 0.001) and 24 hour urinary glucose concentrations (p = 0.012). Compared with HbA1c, concentrations of fructosamine appeared more useful in monitoring short term (three to six weeks) changes after alterations in management of diabetes. Additional advantages were lower cost and technical simplicity of measurement.<\/jats:p>","DOI":"10.1136\/bmj.288.6429.1484","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1484-1486","source":"Crossref","is-referenced-by-count":78,"title":["Serum fructosamine concentrations in patients with type II (non-insulin-dependent) diabetes mellitus during changes in management."],"prefix":"10.1136","volume":"288","author":[{"given":"J R","family":"Baker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R N","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.281.6251.1304","article-title":"Haemoglobin A1 and diabetes: a reappraisal","volume":"281","author":"Anonymous","year":"1980","unstructured":"Anonymous. 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Fructosamine: a new approach to the estimation of serum glycosylprotein. An index of diabetic control. Clin Chim Acta 1983;127:87-95.","journal-title":"Clin Chim Acta"},{"key":"ref_7","first-page":"863","article-title":"Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus","volume":"287","author":"Baker, JR, O.'Connor; JP, Metcalf; PA, Lawson; MR, Johnson; R.N.","year":"1983","unstructured":"Baker JR, O'Connor JP, Metcalf PA, Lawson MR, Johnson RN. Clinical usefulness of estimation of serum fructosamine concentration as a screening test for diabetes mellitus. 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Development and evaluation of a hexokinase\/glucose-6-phosphate dehydrogenase procedure for use as a national glucose reference method. Washington: US Department of Health Education and Welfare, 1976. (Publication No (CDC) 77-8330.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0026-0495(78)90109-9","article-title":"A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography","volume":"27","author":"Cole, R.A.; Soeldner, J.S.; Dunn, P.J.; Bunn, H.F.","year":"1978","unstructured":"Cole RA, Soeldner JS, Dunn PJ, Bunn HF. A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography. Metabolism 1978;27:289-301.","journal-title":"Metabolism"},{"key":"ref_11","article-title":"Practical clinical biochemistry. Vol 1","author":"Varley, H.; Gowenlock, A.H.; Bell, M.","year":"1980","unstructured":"Varley H, Gowenlock AH, Bell M. Practical clinical biochemistry. Vol 1. London: William Heinemann, 1980."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/diacare.3.1.150","article-title":"A critical evaluation of methods of monitoring diabetic control","volume":"3","author":"Tattersall, R.; Walford, S.; Peacock, I.; Gale, E.; Allison, S.","year":"1980","unstructured":"Tattersall R, Walford S, Peacock I, Gale E, Allison S. A critical evaluation of methods of monitoring diabetic control. Diabetes Care 1980;3:150-4.","journal-title":"Diabetes Care"},{"key":"ref_13","article-title":"Molecular biology of human proteins with special reference to plasma proteins. Vol 1","author":"Schultze, H.E.; Heremans, J.F.","unstructured":"Schultze HE, Heremans JF. Molecular biology of human proteins with special reference to plasma proteins. Vol 1. 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