{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:31:20Z","timestamp":1770985880719,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"6430","license":[{"start":{"date-parts":[[1984,5,26]],"date-time":"1984-05-26T00:00:00Z","timestamp":454377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,5,26]]},"abstract":"<jats:p>Spontaneous primary hypothyroidism in adults is usually associated with autoimmune thyroiditis. The hypothesis that hypothyroidism may result from the presence in serum of a factor that blocks stimulation of the thyroid by thyroid stimulating hormone was examined. Serum samples were collected from 28 patients with recently diagnosed primary hypothyroidism. After removal of endogenous thyroid stimulating hormone the effect of the serum on secretion of triiodothyronine induced by thyroid stimulating hormone or thyroid stimulating antibodies was examined in thyroid slices incubated in vitro. Serum samples from six of the patients demonstrated significant blocking of the stimulation by bovine thyroid stimulating hormone. Inhibition of the stimulatory action of thyroid stimulating antibodies was also exhibited by serum samples with blocking activity. It is concluded that in some patients with primary hypothyroidism a serum factor, which is probably an IgG, exists that can block the thyroid response to thyroid stimulating hormone and thyroid stimulating antibodies; it may represent an important mechanism in the pathogenesis of hypothyroidism.<\/jats:p>","DOI":"10.1136\/bmj.288.6430.1559","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1559-1562","source":"Crossref","is-referenced-by-count":41,"title":["Blocking activity to action of thyroid stimulating hormone in serum from patients with primary hypothyroidism."],"prefix":"10.1136","volume":"288","author":[{"given":"N R","family":"Steel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Weightman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kendall-Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM198009253031306","article-title":"Familial neonatal transient hypothyroidism due to maternal TSH-binding inhibitor immunoglobulins","volume":"303","author":"Matsuura, N.; Yamada, Y.; Nohara, Y.","year":"1980","unstructured":"Matsuura N, Yamada Y, Nohara Y, et al. Familial neonatal transient hypothyroidism due to maternal TSH-binding inhibitor immunoglobulins. N EnglJ_ Med 1980;303:738-41.","journal-title":"N EnglJ_ Med"},{"issue":"26","key":"ref_2","volume":"288","author":"MEDICAL, B.R.I.T.I.S.H.","year":"1984","unstructured":"BRITISH MEDICAL JOURNAL VOLUME 288 26 MAy 1984","journal-title":"JOURNAL VOLUME"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1210\/jcem-46-5-734","article-title":"Detection and properties of TSHbinding inhibitor immunoglobulins in patients with Graves'","volume":"46","author":"Endo, K.; Kasagi, K.; Konishi, J.","year":"1978","unstructured":"Endo K, Kasagi K, Konishi J, et al. Detection and properties of TSHbinding inhibitor immunoglobulins in patients with Graves' disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab 1978;46:734-9.","journal-title":"disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jcem-53-6-1263","article-title":"The stimulation of thyroid hormone secretion in vitro by thyroid stimulating antibodies","volume":"53","author":"Atkinson, S.; Kendall-Taylor, P.","year":"1981","unstructured":"Atkinson S, Kendall-Taylor P. The stimulation of thyroid hormone secretion in vitro by thyroid stimulating antibodies. J Clin Endocrinol Metab 1981;53:1263-6.","journal-title":"J Clin Endocrinol Metab"},{"issue":"142","key":"ref_5","first-page":"207","article-title":"Radioimmunoassays employing immunosorbents","volume":"1969","author":"Wide, L.","unstructured":"Wide L. Radioimmunoassays employing immunosorbents. Acta Endocrinol (Copenh) 1969; 142, suppl:207-21.","journal-title":"Acta Endocrinol (Copenh)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2265.1982.tb01607.x","article-title":"An improved radioreceptor assay for TSH receptor antibodies","volume":"17","author":"Shewring, G.; Smith, B.R.","year":"1982","unstructured":"Shewring G, Smith BR. An improved radioreceptor assay for TSH receptor antibodies. Clin Endocrinol 1982;17:409-17.","journal-title":"Clin Endocrinol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1677\/joe.0.0930371","article-title":"Comparison of human and porcine thyroid membranes for radioreceptor assay of bovine thyrotrophin and thyrotrophin-binding inhibiting immunoglobulins","volume":"93","author":"Humphries, H.; Dirmikis, S.; Munro, D.S.","year":"1982","unstructured":"Humphries H, Dirmikis S, Munro DS. Comparison of human and porcine thyroid membranes for radioreceptor assay of bovine thyrotrophin and thyrotrophin-binding inhibiting immunoglobulins. J Endocrinol 1982; 93:371-80.","journal-title":"J Endocrinol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1677\/joe.0.0880339","article-title":"Specific binding of thyroid-stimulating hormone by human serum globulins","volume":"88","author":"Biro, J.","year":"1981","unstructured":"Biro J. Specific binding of thyroid-stimulating hormone by human serum globulins. J Endocrinol 1981;88:339-49.","journal-title":"J Endocrinol"},{"key":"ref_9","first-page":"592","article-title":"Transient neonatal hyperthyrotrophinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone","volume":"286","author":"Lazarus, J.H.; John, R.; Ginsberg, J.","year":"1983","unstructured":"Lazarus JH, John R, Ginsberg J, et al. Transient neonatal hyperthyrotrophinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone. Br MedJ7 1983;286:592-4."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/289594a0","article-title":"Thyroid growth-blocking antibodies in primary myxoedema","volume":"289","author":"Drexhage, H.A.; Bottazzo, G.F.; Bitensky, L.; Chayen, J.; Doniach, D.","year":"1981","unstructured":"Drexhage HA, Bottazzo GF, Bitensky L, Chayen J, Doniach D. Thyroid growth-blocking antibodies in primary myxoedema. Nature 1981;289: 594-6.","journal-title":"Nature"},{"key":"ref_11","first-page":"3180","article-title":"Monoclonal antibodies to the thyrotrophin receptor: implications for receptor structure and the","volume-title":"action of autoantibodies. Proc Natl Acad Sci","volume":"78","author":"Yavin, E.; Yavin, Z.; Schneider, M.D.; Kohn, L.D.","year":"1981","unstructured":"Yavin E, Yavin Z, Schneider MD, Kohn LD. Monoclonal antibodies to the thyrotrophin receptor: implications for receptor structure and the action of autoantibodies. Proc Natl Acad Sci USA 1981;78:3180-4."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1210\/jcem-57-3-544","article-title":"Inhibition of thyrotrophin-induced adenosine 3'5'-monophosphate increase by immunoglobulins from patients with primary myxedema","volume":"57","author":"IKonishi, J.; Iida, Y.; Endo, K.","year":"1983","unstructured":"IKonishi J, Iida Y, Endo K, et al. Inhibition of thyrotrophin-induced adenosine 3'5'-monophosphate increase by immunoglobulins from patients with primary myxedema. J Clin Endocrinol Metab 1983;57: 544-9.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_13","article-title":"Accepted","year":"1984","unstructured":"(Accepted 23 February 1984)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6430.1559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6430.1559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T21:14:31Z","timestamp":1765401271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6430.1559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5,26]]},"references-count":13,"journal-issue":{"issue":"6430","published-online":{"date-parts":[[1984,5,26]]},"published-print":{"date-parts":[[1984,5,26]]}},"alternative-id":["10.1136\/bmj.288.6430.1559"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6430.1559","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5,26]]}}}