{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:48:21Z","timestamp":1773164901289,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"6430","license":[{"start":{"date-parts":[[1984,5,26]],"date-time":"1984-05-26T00:00:00Z","timestamp":454377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,5,26]]},"abstract":"<jats:p>Thirty eight patients with known or suspected phaeochromocytoma were studied by radioisotope imaging after intravenous administration of iodine-131-meta- iodobenzylguanidine (131I- mIBG ), a radiopharmaceutical which has affinity for chromaffin tumours. Seventeen positive results (including one false positive) and 21 negative results (including two false negatives) were obtained. Clinical accuracy was 92%. Urinary noradrenaline concentrations were raised in all patients with confirmed phaeochromocytoma. These findings show that 131I- mIBG is of value in localising and assessing the extent of chromaffin tumours.<\/jats:p>","DOI":"10.1136\/bmj.288.6430.1587","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1587-1591","source":"Crossref","is-referenced-by-count":51,"title":["New approach to the localisation of phaeochromocytoma: imaging with iodine-131-meta-iodobenzylguanidine."],"prefix":"10.1136","volume":"288","author":[{"given":"D M","family":"Ackery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Tippett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B R","family":"Condon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H E","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Wyeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1056\/NEJM198107023050103","article-title":"Scintigraphic localisation of pheochromocytoma","volume":"305","author":"Sisson, J.C.; Frager, M.S.; Valk, T.W.","year":"1981","unstructured":"Sisson JC, Frager MS, Valk TW, et al. Scintigraphic localisation of pheochromocytoma. N EnglJ7 Med 1981;305:12-7.","journal-title":"N EnglJ7 Med"},{"key":"ref_2","first-page":"1153","article-title":"Disseminated malignant phaeochromocytoma: localisation with iodine-131-labelled meta-iodobenzylguanidine","volume":"285","author":"Sutton, H.; Wyeth, P.; Allen, A.P.","year":"1982","unstructured":"Sutton H, Wyeth P, Allen AP, et al. Disseminated malignant phaeochromocytoma: localisation with iodine-131-labelled meta-iodobenzylguanidine. Br MedJ7 1982;285:1153-4."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.1984.tb00054.x","article-title":"Scintigraphic localization of phaeochromocytomas","volume":"20","author":"Fischer, M.; Vetter, W.; Winterberg, B.","year":"1984","unstructured":"Fischer M, Vetter W, Winterberg B, et al. Scintigraphic localization of phaeochromocytomas. Clin Endocrinol (Oxf) 1984;20:1-7.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2265.1984.tb00074.x","article-title":"Malignant phaeochromocytoma: clinical, biochemical and scintigraphic characterization","volume":"20","author":"Shapiro, B.; Sisson, J.C.; Lloyd, R.; Nakajo, M.; Satterlee, W.; Beierwaltes, W.H.","year":"1984","unstructured":"Shapiro B, Sisson JC, Lloyd R, Nakajo M, Satterlee W, Beierwaltes WH. Malignant phaeochromocytoma: clinical, biochemical and scintigraphic characterization. Clin Endocrinol (Oxf) 1984;20:189-203.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref_5","first-page":"349","article-title":"Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [\"31I] iodobenzylguanidine","volume":"21","author":"Wieland, D.M.; Wu, J.-L.; Brown, L.E.; Mangner, T.J.; Swanson, D.P.; Beierwaltes, W.H.","year":"1980","unstructured":"Wieland DM, Wu J-L, Brown LE, Mangner TJ, Swanson DP, Beierwaltes WH. Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [\"31I] iodobenzylguanidine. J Nucl Med 1980;21:349-53.","journal-title":"J Nucl Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1021\/jo00347a022","article-title":"Solid-phase exchange radioiodination of aryl iodides. Facilitation by ammonium sulphate","volume":"47","author":"Mangner, T.; Wu, J.-L.; Wieland, D.M.","year":"1982","unstructured":"Mangner T, Wu J-L, Wieland DM. Solid-phase exchange radioiodination of aryl iodides. Facilitation by ammonium sulphate. J Org Chem 1982;47: 1484-8.","journal-title":"J Org Chem"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/clinchem\/25.2.256","article-title":"Analysis for urinary catecholamines by liquid chromatography with amperometric detection: methodology and clinical interpretation of results","volume":"25","author":"Moyer, T.P.; Jiang, N.-S.; Tyce, G.M.; Sheps, S.G.","year":"1979","unstructured":"Moyer TP, Jiang N-S, Tyce GM, Sheps SG. Analysis for urinary catecholamines by liquid chromatography with amperometric detection: methodology and clinical interpretation of results. Clin Chem 1979;25: 256-63.","journal-title":"Clin Chem"},{"key":"ref_8","first-page":"672","article-title":"The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131] iodobenzylguandine (I-131 MIBG) in man: evaluation by scintigraphy","volume":"24","author":"Nakajo, M.; Shapiro, B.; Copp, J.","year":"1983","unstructured":"Nakajo M, Shapiro B, Copp J, et al. The normal and abnormal distribution of the adrenomedullary imaging agent m-[I-131] iodobenzylguandine (I-131 MIBG) in man: evaluation by scintigraphy. J Nuci Med 1983; 24:672-82.","journal-title":"J Nuci Med"},{"key":"ref_9","first-page":"460","article-title":"Localisation of pheochromocytoma by computed tomography. N EnglJ'","volume":"299","author":"Stewart, B.H.; Bravo, E.L.; Haaga, J.; Meaney, T.F.; Tarazi, R.","year":"1978","unstructured":"Stewart BH, Bravo EL, Haaga J, Meaney TF, Tarazi R. Localisation of pheochromocytoma by computed tomography. N EnglJ' Med 1978;299: 460-1.","journal-title":"Med"},{"key":"ref_10","first-page":"477","article-title":"CT of pheochromocytoma","volume":"135","author":"Thomas, J.L.; Bernardino, M.E.; Samaan, N.A.; Hickey, R.C.","year":"1980","unstructured":"Thomas JL, Bernardino ME, Samaan NA, Hickey RC. CT of pheochromocytoma. AJ'R 1980;135:477-82.","journal-title":"AJ'R"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2214\/ajr.134.2.277","article-title":"CT for pheochromocytoma diagnosis","volume":"134","author":"Laursen, K.; Damgaard-Pedersen, K.","year":"1980","unstructured":"Laursen K, Damgaard-Pedersen K. CT for pheochromocytoma diagnosis. AJR 1980;134:277-80.","journal-title":"AJR"},{"key":"ref_12","first-page":"3949","article-title":"Computed tomography in adrenal disease","volume":"34","author":"Adams, J.E.; Johnson, R.J.; Rickards, D.; Isherwood, I.","year":"1983","unstructured":"Adams JE, Johnson RJ, Rickards D, Isherwood I. Computed tomography in adrenal disease. Clin Radiol 1983;34:3949.","journal-title":"Clin Radiol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1148\/radiology.143.1.7063713","article-title":"Computed tomography versus ultrasound of the adrenal gland: a prospective study","volume":"143","author":"Abrams, H.L.; Siegelman, S.S.; Adams, D.F.","year":"1982","unstructured":"Abrams HL, Siegelman SS, Adams DF, et al. Computed tomography versus ultrasound of the adrenal gland: a prospective study. Radiology 1982;143:121-8.","journal-title":"Radiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2214\/ajr.135.6.1167","article-title":"Sonography of the adrenal glands: normal glands and small masses","volume":"135","author":"Yeh, H.-C.","year":"1980","unstructured":"Yeh H-C. Sonography of the adrenal glands: normal glands and small masses. AJR 1980;135:1167-77.","journal-title":"AJR"},{"key":"ref_15","first-page":"358","article-title":"Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzyl-guanidine: concise communication","volume":"22","author":"Wieland, D.M.; Brown, L.E.; Tobes, M.C.","year":"1981","unstructured":"Wieland DM, Brown LE, Tobes MC, et al. Imaging the primate adrenal medulla with [123I] and [131I] meta-iodobenzyl-guanidine: concise communication. J Nucl Med 1981;22:358-64.","journal-title":"J Nucl Med"},{"key":"ref_16","article-title":"Pheochromocytoma","author":"Manger, W.M.; Gifford, R.W.","year":"1977","unstructured":"Manger WM, Gifford RW. Pheochromocytoma. New York: SpringerVerlag, 1977."},{"key":"ref_17","article-title":"The natural history of the chromaffin cell","author":"Coupland, R.E.","year":"1965","unstructured":"Coupland RE. The natural history of the chromaffin cell. London: Longmans Green, 1965."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/000456328201900602","article-title":"Catecholamine measurements in phaeochromocytoma: a review","volume":"19","author":"Causon, R.C.; Brown, M.J.","year":"1982","unstructured":"Causon RC, Brown MJ. Catecholamine measurements in phaeochromocytoma: a review. Ann Clin Biochem 1982;19:396-404.","journal-title":"Ann Clin Biochem"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI104898","article-title":"Turnover and metabolism of catecholamines in patients with pheochromocytoma","volume":"43","author":"Crout, JR, Sjoerdsma; A.","year":"1964","unstructured":"Crout JR, Sjoerdsma A. Turnover and metabolism of catecholamines in patients with pheochromocytoma. J Clin Invest 1964;43:94-102.","journal-title":"J Clin Invest"},{"key":"ref_20","first-page":"197","article-title":"Radiopharmaceutical treatment of malignant pheochromocytoma","volume":"24","author":"Sisson, J.C.; Shapiro, B.; Beierwaltes, W.H.","year":"1984","unstructured":"Sisson JC, Shapiro B, Beierwaltes WH, et al. Radiopharmaceutical treatment of malignant pheochromocytoma. J Nucl Med 1984;24:197-206.","journal-title":"J Nucl Med"},{"key":"ref_21","series-title":"Proceedings of the third international symposium on radiopharmaceutical dosimetry, Oak","first-page":"213","article-title":"Human absorbed dose calculations for iodine-131 and iodine-123 labeled meta-iodobenzyl-guanidine (mIBG): a potential myocardial and adrenal medulla imaging agent","author":"Swanson, D.P.; Carey, J.E.; Brown, L.E.","year":"1981","unstructured":"Swanson DP, Carey JE, Brown LE, et al. Human absorbed dose calculations for iodine-131 and iodine-123 labeled meta-iodobenzyl-guanidine (mIBG): a potential myocardial and adrenal medulla imaging agent. In: Proceedings of the third international symposium on radiopharmaceutical dosimetry, Oak Ridge, Tennessee. Oak Ridge, Tenn: Oak Ridge Associated Universities, 1981:213-24."},{"key":"ref_22","author":"Accepted","year":"1984","unstructured":"(Accepted 7 March 1984)"},{"key":"ref_23","first-page":"1387","article-title":"Further reading Critchley EMR","volume":"1","author":"BMedicineIntemational, Matthews","year":"1983","unstructured":"Further reading Critchley EMR, Matthews B, eds. MedicineIntemational 1983;1:1387-525."},{"key":"ref_24","article-title":"Brain's diseases of the nervous system","author":"Walton, J.N.","year":"1977","unstructured":"Walton JN. Brain's diseases of the nervous system. 8th ed. Oxford: Oxford Medical Publications, 1977.","edition":"8th ed"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.288.6430.1587","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.288.6430.1587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T21:15:59Z","timestamp":1765401359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.288.6430.1587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5,26]]},"references-count":24,"journal-issue":{"issue":"6430","published-online":{"date-parts":[[1984,5,26]]},"published-print":{"date-parts":[[1984,5,26]]}},"alternative-id":["10.1136\/bmj.288.6430.1587"],"URL":"https:\/\/doi.org\/10.1136\/bmj.288.6430.1587","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5,26]]}}}