{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:45:00Z","timestamp":1780065900357,"version":"3.54.0"},"reference-count":19,"publisher":"BMJ","issue":"6436","license":[{"start":{"date-parts":[[1984,7,7]],"date-time":"1984-07-07T00:00:00Z","timestamp":458006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,7,7]]},"abstract":"<jats:p>Vesicoureteric reflux was produced in eight piglets by opening their bladders and slitting the anterior intravesical wall of the ureter. Cystography confirmed the presence of bilateral reflux in six piglets and unilateral reflux in two. Six to eight weeks later the bladder was again opened and Teflon paste injected in the space behind the intravesical ureter, thereby creating a support for the submucosal ureter. Cystography four to six weeks after injection of Teflon paste showed absence of reflux in all animals. Intravenous pyelography showed obstruction at the vesicoureteric junction in only one of the 14 treated ureters and this was later confirmed at necropsy. Animals were followed up from one to six months and then were killed. Gross examination of the vesicoureteric region showed a well circumscribed subureteric Teflon mass of firm consistency, retaining its shape and position at the site of the injection. Histological examination showed encapsulation of the implant by a thin layer of fibrous tissue and a foreign body granulomatous reaction with histiocytes and giant cells within the implant. Hence it is technically feasible to correct experimentally produced vesicoureteric reflux in the piglet by intravesical injection of Teflon paste--a relatively inert material. It may now be possible to treat vesicoureteric reflux in man by endoscopic injection of Teflon behind the intravesical ureter.<\/jats:p>","DOI":"10.1136\/bmj.289.6436.5","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"5-7","source":"Crossref","is-referenced-by-count":154,"title":["Correction of experimentally produced vesicoureteric reflux in the piglet by intravesical injection of Teflon."],"prefix":"10.1136","volume":"289","author":[{"given":"P","family":"Puri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1984,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0022-5347(17)65025-0","article-title":"The anatomical basis and dynamics of vesicoureteric reflux","volume":"87","author":"Stephens, F.D.; Lenaghan, D.","year":"1962","unstructured":"Stephens FD, Lenaghan D. The anatomical basis and dynamics of vesicoureteric reflux. J Urol 1962;87:669-80.","journal-title":"J Urol"},{"key":"ref_2","first-page":"441","article-title":"Natural history of vesicoureteric reflux: outcome of a trial of nonoperative therapy","volume":"1","author":"King, L.R.; Kazmi, S.O.; Belman, A.B.","year":"1974","unstructured":"King LR, Kazmi SO, Belman AB. Natural history of vesicoureteric reflux: outcome of a trial of nonoperative therapy. Urol Clin North Am 1974;1:441-5.","journal-title":"Urol Clin North Am"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0022-5347(17)62184-0","article-title":"The ureteral orifice: its configuration and competency","volume":"102","author":"Lyon, R.P.; Marshall, S.; Tanago, E.A.","year":"1969","unstructured":"Lyon RP, Marshall S, Tanago EA. The ureteral orifice: its configuration and competency. J Urol 1969;102:504-9.","journal-title":"J Urol"},{"key":"ref_4","first-page":"133","article-title":"Reflux nephropathy. Hosp Pract","volume":"17","author":"Hodson, C.J.; Cotran, R.S.","year":"1982","unstructured":"Hodson CJ, Cotran RS. Reflux nephropathy. Hosp Pract 1982;17:133-56."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0022-5347(17)53184-5","article-title":"Familial vesicoureteral reflux: a prospective study","volume":"128","author":"Jerkins, G.R.; Noe, H.N.","year":"1982","unstructured":"Jerkins GR, Noe HN. Familial vesicoureteral reflux: a prospective study. J Urol 1982;128:774-8.","journal-title":"J Urol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/bmj.2.6029.203","article-title":"Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects","volume":"ii:","author":"Smellie, J.M.; Gruneberg, R.N.; Leakey, A.","year":"1976","unstructured":"Smellie JM, Gruneberg RN, Leakey A, et al. Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects. Br MedJ7 1976;ii:203-6.","journal-title":"Br MedJ7"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0022-5347(17)66369-9","article-title":"An operative technique for the correction of vesicoureteric reflux","volume":"79","author":"Politano, V.A.; Leadbetter, W.F.","year":"1958","unstructured":"Politano VA, Leadbetter WF. An operative technique for the correction of vesicoureteric reflux. Jf Urol 1958;79:932-41.","journal-title":"Jf Urol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0022-5347(17)65934-2","article-title":"Ureterovesical anastomosis: description and evaluation of a technique","volume":"82","author":"AJ, Jr, Paquin","year":"1959","unstructured":"Paquin AJ Jr. Ureterovesical anastomosis: description and evaluation of a technique. J Urol 1959;82:573-83.","journal-title":"J Urol"},{"key":"ref_9","first-page":"1","article-title":"Ureterozystoneostomie: eine neue antireflux Technik","volume":"6","author":"Cohen, S.J.","year":"1975","unstructured":"Cohen SJ. Ureterozystoneostomie: eine neue antireflux Technik. Aktuel Urol 1975; 6:1-9.","journal-title":"Aktuel Urol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/000348946307200209","article-title":"Alleviation of aphonia or dysphonia through intrachordal injection of teflon paste","volume":"72","author":"Arnold, G.E.","year":"1963","unstructured":"Arnold GE. Alleviation of aphonia or dysphonia through intrachordal injection of teflon paste. Ann Otol Rhinol Laryngol 1963;72:384-95.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archotol.1969.00770030100020","article-title":"Teflon injection for vocal cord paralysis","volume":"90","author":"Goff, W.F.","year":"1969","unstructured":"Goff WF. Teflon injection for vocal cord paralysis. Arch Otolaryngol 1969;90: 98-102.","journal-title":"Arch Otolaryngol"},{"key":"ref_12","first-page":"180","article-title":"Periurethral Teflon injection for urinary incontinence","volume":"111","author":"Politano, V.A.; Small, M.P.; Harper, J.M.; Lynn, C.M.","year":"1974","unstructured":"Politano VA, Small MP, Harper JM, Lynn CM. Periurethral Teflon injection for urinary incontinence. J7 Urol 1974;111:180-3."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-5347(17)53852-5","article-title":"Periurethral polytetrafluorethylene injection for urinary incontinence","volume":"127","author":"Politano, V.A.","year":"1982","unstructured":"Politano VA. Periurethral polytetrafluorethylene injection for urinary incontinence. J Urol 1982;127:439-42.","journal-title":"J Urol"},{"key":"ref_14","first-page":"192","article-title":"Endoscopic injection of Teflon to treat urinary incontinence in women","volume":"288","author":"Schulman, C.C.; Simon, J.; Wespes, E.; Germeau, F.","year":"1984","unstructured":"Schulman CC, Simon J, Wespes E, Germeau F. Endoscopic injection of Teflon to treat urinary incontinence in women. Br MedJ7 1984;288:192."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/archotol.1967.00760050552014","article-title":"Human larynx injected with Teflon paste. Histologic study of innervation and tissue reaction","volume":"86","author":"Stone, J.W.; Arnold, G.E.","year":"1967","unstructured":"Stone JW, Arnold GE. Human larynx injected with Teflon paste. Histologic study of innervation and tissue reaction. Arch Otolaryngol 1967;86:550-61.","journal-title":"Arch Otolaryngol"},{"key":"ref_16","first-page":"1","article-title":"The pathogenesis of reflux nephropathy","volume":"\"Radiol\" # \"suppl 13:\"","author":"Hodson, C.J.; Maling, T.M.J.; McManamon, L.M.","year":"1975","unstructured":"Hodson CJ, Maling TMJ, McManamon LM. The pathogenesis of reflux nephropathy. BrJ3 Radiol 1975;suppl 13:1-26.","journal-title":"BrJ3"},{"key":"ref_17","first-page":"105","article-title":"Renal papillary morphology and intrarenal reflux in young pig","volume":"3","author":"Ransley, P.G.; Risdon, A.","year":"1975","unstructured":"Ransley PG, Risdon A. Renal papillary morphology and intrarenal reflux in young pig. Urol Res 1975;3:105-9.","journal-title":"Urol Res"},{"key":"ref_18","author":"Accepted","year":"1984","unstructured":"(Accepted 29 May 1984)"},{"key":"ref_19","article-title":"Vesicoureteric reflux has been a controversial subject since 1952, when Hutch highlighted its association with renal damage.' Its role in the development and progression of chronic pyelonephritis is now widely recognised. The indications for antireflux surgery have been widely debated. There is general agreement that patients with the more severe grades of reflux (grades IV and V of the international classification2) and those who develop \"breakthrough\" bacteriuria while having antimicrobial chemotherapy should have antireflux surgery","unstructured":"Vesicoureteric reflux has been a controversial subject since 1952, when Hutch highlighted its association with renal damage.' Its role in the development and progression of chronic pyelonephritis is now widely recognised. The indications for antireflux surgery have been widely debated. There is general agreement that patients with the more severe grades of reflux (grades IV and V of the international classification2) and those who develop \"breakthrough\" bacteriuria while having antimicrobial chemotherapy should have antireflux surgery."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6436.5","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6436.5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T21:52:30Z","timestamp":1765403550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6436.5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7,7]]},"references-count":19,"journal-issue":{"issue":"6436","published-online":{"date-parts":[[1984,7,7]]},"published-print":{"date-parts":[[1984,7,7]]}},"alternative-id":["10.1136\/bmj.289.6436.5"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6436.5","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7,7]]}}}