{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:21:36Z","timestamp":1765405296085,"version":"3.46.0"},"reference-count":6,"publisher":"BMJ","issue":"6443","license":[{"start":{"date-parts":[[1984,8,25]],"date-time":"1984-08-25T00:00:00Z","timestamp":462240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,8,25]]},"abstract":"<jats:p>Owing to recent findings of certain unusual sex steroid binding in liver disease--particularly an allosteric biphasic pattern (pattern A) unique to the serum of patients with hepatocellular carcinoma--the serum binding characteristics for 5 alpha-dihydrotestosterone were examined in serum samples from six patients with primary biliary cirrhosis who had developed hepatocellular carcinoma. In all serum samples taken after the development of tumour pattern A binding only was obtained, and in four cases in which earlier samples were also examined there was a transformation from the normal, non-specific binding pattern, or an allosteric plateau pattern seen in non-malignant liver disease (designated D and C respectively), to pattern A coincident with the rise in serum alpha fetoprotein. In one patient chemotherapy leading to a fall in alpha fetoprotein abolished pattern A binding, showing further its close association with tumour growth. The value of pattern A binding as a tumour marker in hepatocellular carcinoma warrants further study.<\/jats:p>","DOI":"10.1136\/bmj.289.6443.459","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"459-460","source":"Crossref","is-referenced-by-count":3,"title":["Sex steroid binding patterns in primary biliary cirrhosis complicated by hepatocellular carcinoma."],"prefix":"10.1136","volume":"289","author":[{"given":"M J","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,8,25]]},"reference":[{"key":"ref_1","first-page":"\"977","article-title":"column employing Cibacron blue F3G-A-Sepharose 4B. I-Sex hormone binding globulin","volume":"8","author":"Intertnational Research Communication System Medical Science","year":"1977","unstructured":"column employing Cibacron blue F3G-A-Sepharose 4B. I-Sex hormone binding globulin. J Steroid Biochem 1977;8:977-83. !Wilkinson ML, Iqbal MJ, Williams R. A new sex-steroid binding protein in foetal liver. Intertnational Research Communication System Medical Science 1983;11: 1123-4.","journal-title":"J Steroid Biochem; Wilkinson ML, Iqbal MJ, Williams R. A new sex-steroid binding protein in foetal liver"},{"key":"ref_2","first-page":"1","article-title":"A new circulating sex-steroid binding protein in benign and malignant liver disease and other malignancies associated with sex-steroids","volume":"1","author":"Iqbal, M.J.; Wilkinson, M.L.; Williams, R.","year":"1983","unstructured":"Iqbal MJ, Wilkinson ML, Williams R. A new circulating sex-steroid binding protein in benign and malignant liver disease and other malignancies associated with sex-steroids. International Research Communication System Medical Science 1983;1 1:1125-6.","journal-title":"International Research Communication System Medical Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.20.3.255","article-title":"Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases","volume":"20","author":"Krasner, N.; Johnson, P.J.; Portmann, B.C.; Watkinson, G.; MacSween, R.N.M.; Williams, R.","year":"1979","unstructured":"Krasner N, Johnson PJ, Portmann BC, Watkinson G, MacSween RNM, Williams R. Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases. Gut 1979;20:255-8.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/jcem-39-3-589","article-title":"The lack of estrogen binding by human alphafetoprotein","volume":"39","author":"Swartz, S.K.; Soloff, M.S.","year":"1974","unstructured":"Swartz SK, Soloff MS. The lack of estrogen binding by human alphafetoprotein. J Clin Endocrinol Metab 1974;39:589-94.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/bjc.1983.268","article-title":"Sex-steroid receptor proteins in foetal, adult and malignant human liver tissue","volume":"48","author":"Iqbal, M.J.; Wilkinson, M.L.; Johnson, P.J.; Williams, R.","year":"1983","unstructured":"Iqbal MJ, Wilkinson ML, Johnson PJ, Williams R. Sex-steroid receptor proteins in foetal, adult and malignant human liver tissue. Br J Cancer 1983;48:791-6.","journal-title":"Br J Cancer"},{"key":"ref_6","article-title":"Hepatocellular carcinoma in primary biliary cirrhosis: detection by alphafetoprotein estimation","author":"WM, Wilkinson M.L.; PJ, Johnson; R, Williams","year":"1984","unstructured":"Hepatocellular carcinoma in primary biliary cirrhosis: detection by alphafetoprotein estimation. Gastroenterology (in press). Melia WM, Wilkinson ML, Johnson PJ, Williams R. Hepatocellular carcinoma in the non-cirrhotic liver-a review. Q J Med (in press). (Accepted 17 May 1984)","journal-title":"Q J Med; Hepatocellular carcinoma in the non-cirrhotic liver-a review"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6443.459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6443.459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:18:20Z","timestamp":1765405100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6443.459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,25]]},"references-count":6,"journal-issue":{"issue":"6443","published-online":{"date-parts":[[1984,8,25]]},"published-print":{"date-parts":[[1984,8,25]]}},"alternative-id":["10.1136\/bmj.289.6443.459"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6443.459","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,8,25]]}}}