{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:21:55Z","timestamp":1765405315227,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6443","license":[{"start":{"date-parts":[[1984,8,25]],"date-time":"1984-08-25T00:00:00Z","timestamp":462240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,8,25]]},"abstract":"<jats:p>Between 1981 and 1983, 3165 consecutive specimens of cord blood were tested at the Central Middlesex Hospital for the presence of an abnormal haemoglobin: the incidence of sickle cell trait was 2.8%, of HbC trait 0.9%, and the overall incidence of an abnormal haemoglobin at birth was 6.9%. Five babies with homozygous sickle cell disease, three with HbSC, and three with either HbCC or HbC beta thalassaemia were detected. Twenty two per cent of the mothers were of Afro-Caribbean origin. The cost of the test was 30p. An H6000 blood count was carried out on 1000 consecutive cord blood samples. The mean red cell volume was 97.95 (SD 3.67) fl. Thirteen cord blood samples had a mean cell volume below 85 fl, and all contained Hb Barts. In addition, six samples with a mean cell volume between 86 and 92 fl also showed Hb Barts on electrophoresis. The overall incidence of Hb Barts was 2.1%. These results indicate that the incidence of HbSS and HbSC on neonatal screening in Brent is similar to that found in the urban areas of North America and that the number may be predicted from the number of births to mothers of Afro-Caribbean origin.<\/jats:p>","DOI":"10.1136\/bmj.289.6443.479","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"479-480","source":"Crossref","is-referenced-by-count":18,"title":["Screening cord blood for sickle haemoglobinopathies in Brent."],"prefix":"10.1136","volume":"289","author":[{"given":"J","family":"Henthorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Anionwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Brozovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/adc.51.2.127","article-title":"Neonatal screening for haemoglobinopathy. Results in 7691 Manchester newborns","volume":"51","author":"Evans, D.I.K.; Blair, V.M.","year":"1976","unstructured":"Evans DIK, Blair VM. Neonatal screening for haemoglobinopathy. Results in 7691 Manchester newborns. Arch Dis Child 1976;51:127-30.","journal-title":"Arch Dis Child"},{"key":"ref_2","first-page":"933","article-title":"Neonatal screening for sickle haemoglobinopathies in Birmingham. Br MedJ3","volume":"284","author":"Griffiths, K.D.; Raine, D.N.; Mann, JR","year":"1982","unstructured":"Griffiths KD, Raine DN, Mann JR. Neonatal screening for sickle haemoglobinopathies in Birmingham. Br MedJ3 1982;284:933-5."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2105\/AJPH.73.3.249","article-title":"Current sickle cell screening program for newborns in New York City 1979-1980","volume":"73","author":"Grover, R.; Shahidi, S.; Fisher, B.; Goldberg, D.; Wethers, D.","year":"1983","unstructured":"Grover R, Shahidi S, Fisher B, Goldberg D, Wethers D. Current sickle cell screening program for newborns in New York City 1979-1980. Am Jf Public Health 1983;73:249-52.","journal-title":"Am Jf Public Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1001\/archpedi.1984.02140390036011","article-title":"Newborn screening for sickling hemoglobinopathies. Houston 1976-1980","volume":"138","author":"Nussbaum, R.L.; Powell, C.; Graham, H.L.; Caskey, C.T.; Fernback, D.J.","year":"1984","unstructured":"Nussbaum RL, Powell C, Graham HL, Caskey CT, Fernback DJ. Newborn screening for sickling hemoglobinopathies. Houston 1976-1980. Am J Dis Child 1984;138:44-8.","journal-title":"Am J Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/clinchem\/20.6.666","article-title":"Screening cord bloods for detection of sickle cell disease","volume":"20","author":"Serjeant, E.B.; Forbes, M.; Williams, L.L.; Serjeant, G.R.","year":"1974","unstructured":"Serjeant EB, Forbes M, Williams LL, Serjeant GR. Screening cord bloods for detection of sickle cell disease in Jamaica. Clin Chem 1974;20:666-9.","journal-title":"in Jamaica. Clin Chem"},{"key":"ref_6","first-page":"1515","article-title":"Early deaths in Jamaican children with sickle cell disease","volume":"i:","author":"Rogers, D.W.; Clarke, J.M.; Cupidore, L.; Ramlal, A.M.; Sparke, B.R.; Serjeant, G.R.","year":"1978","unstructured":"Rogers DW, Clarke JM, Cupidore L, Ramlal AM, Sparke BR, Serjeant GR. Early deaths in Jamaican children with sickle cell disease. Br Med 3r 1978;i: 1515-6.","edition":"Br Med 3r"},{"key":"ref_7","first-page":"267","article-title":"Natural history of sickle cell disease: the first ten years","volume":"12","author":"Powars, DR","year":"1975","unstructured":"Powars DR. Natural history of sickle cell disease: the first ten years. Semin Hematol 1975;12:267-83.","journal-title":"Semin Hematol"},{"key":"ref_8","first-page":"1439","article-title":"Sickle cell anaemia in infancy","volume":"7","author":"Anonymous","year":"1978","unstructured":"Anonymous. Sickle cell anaemia in infancy. Br Med 7 1978;i:1439.","journal-title":"Br Med"},{"key":"ref_9","first-page":"1141","article-title":"Early infant death in sickle cell disease","volume":"i:","author":"Anonymous","year":"1983","unstructured":"Anonymous. Early infant death in sickle cell disease. Lancet 1983;i:1141-2.","journal-title":"Lancet"},{"article-title":"Accepted 5","year":"1984","key":"ref_10","unstructured":"(Accepted 5 July 1984)"},{"key":"ref_11","article-title":"Indoor climate","author":"DA, I.McIntyre","year":"1980","unstructured":"I McIntyre DA. Indoor climate. London: Applied Science Publishers, 1980."},{"key":"ref_12","first-page":"1679","article-title":"Fitting the task to the man","volume":"225","author":"Grandjean, E.","year":"1980","unstructured":"Grandjean E. Fitting the task to the man. London: Taylor and Francis Ltd, 1980. ' Lee WR. Little shocks. Practitioner 1981;225:1679-83.","journal-title":"Practitioner; Lee WR. Little shocks"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6443.479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6443.479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:19:08Z","timestamp":1765405148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6443.479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,25]]},"references-count":12,"journal-issue":{"issue":"6443","published-online":{"date-parts":[[1984,8,25]]},"published-print":{"date-parts":[[1984,8,25]]}},"alternative-id":["10.1136\/bmj.289.6443.479"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6443.479","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,8,25]]}}}