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Patients who had been admitted to the county's only hospital with acute cholecystitis and who were part of this sample were studied, and controls matched for age and sex were drawn from the sample. The purchase of thiazides and other drugs prescribed to the patients with acute cholecystitis was compared with that of the controls. The estimated relative risk of developing acute cholecystitis in patients who had purchased thiazides in the year before admission to hospital, as compared with those who had not, was 2.1 (95% confidence limit 1.1-3.9). As it has been reliably reported that the use of thiazides is not itself associated with cholelithiasis, the association found between thiazides and cholecystitis suggests that thiazides may increase the risk of acute cholecystitis developing in a patient with gall stones.<\/jats:p>","DOI":"10.1136\/bmj.289.6446.654","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"654-655","source":"Crossref","is-referenced-by-count":14,"title":["Acute cholecystitis and thiazides."],"prefix":"10.1136","volume":"289","author":[{"given":"W","family":"Van der Linden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Edlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1056\/NEJM198009043031002","article-title":"Thiazides and acute cholecystitis","volume":"303","author":"Rosenberg, L.; Shapiro, S.; Slone, D.; Kaufman, D.W.; Miettinen, O.S.; Stolley, P.D.","year":"1980","unstructured":"Rosenberg L, Shapiro S, Slone D, Kaufman DW, Miettinen OS, Stolley PD. 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Department of Internal Medicine, Ostersund's Hospital, and Department of Clinical Pharmacology, Karolinska Institute, Sweden: 1977, 35 pp. (Thesis.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/oxfordjournals.aje.a112220","article-title":"Estimability and estimation in case-referent studies","volume":"103","author":"Miettinen, O.S.","year":"1976","unstructured":"Miettinen OS. Estimability and estimation in case-referent studies. AmJ Epidemiol 1976;103:226-35.","journal-title":"AmJ Epidemiol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2307\/3002000","article-title":"Limitations of the application of fourfold table analysis to hospital data","volume":"2","author":"Berkson, J.","year":"1946","unstructured":"Berkson J. Limitations of the application of fourfold table analysis to hospital data. 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Lancet 1975;ii:2926.","journal-title":"Lancet"},{"key":"ref_10","author":"Accepted 93July 1984)","unstructured":"(Accepted 93July 1984)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6446.654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6446.654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:30:07Z","timestamp":1765405807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6446.654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9,15]]},"references-count":10,"journal-issue":{"issue":"6446","published-online":{"date-parts":[[1984,9,15]]},"published-print":{"date-parts":[[1984,9,15]]}},"alternative-id":["10.1136\/bmj.289.6446.654"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6446.654","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9,15]]}}}