{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:32:12Z","timestamp":1772915532860,"version":"3.50.1"},"reference-count":6,"publisher":"BMJ","issue":"6448","license":[{"start":{"date-parts":[[1984,9,29]],"date-time":"1984-09-29T00:00:00Z","timestamp":465264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,9,29]]},"abstract":"<jats:p>A study was performed to see whether ketanserin, a serotonin antagonist, would reduce the raised concentrations of adrenocorticotrophic hormone (ACTH) in patients with Nelson's syndrome. Six patients who had undergone bilateral adrenalectomy for Cushing's disease and who had Nelson's syndrome were given ketanserin 40 mg twice daily and placebo, for at least two months each, in a double blind crossover study. Ketanserin had no effect on ACTH concentrations. In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome. These results show that it is not indicated in these patients.<\/jats:p>","DOI":"10.1136\/bmj.289.6448.787","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"787-788","source":"Crossref","is-referenced-by-count":4,"title":["Effect of an oral serotonin antagonist, ketanserin, on plasma ACTH concentrations in Nelson's syndrome."],"prefix":"10.1136","volume":"289","author":[{"given":"R W","family":"Prescott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1210\/jcem-56-5-985","article-title":"The evaluation of sodium valproate in the treatment of Nelson's syndrome","volume":"56","author":"Dornhorst, A.; Jenkins, J.S.; Lamberts, S.W.J.","year":"1983","unstructured":"Dornhorst A, Jenkins JS, Lamberts SWJ, et al. The evaluation of sodium valproate in the treatment of Nelson's syndrome. J Clin Endocrinol Metab 1983;56:985-91.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198002213020808","article-title":"Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment","volume":"302","author":"Aronin, N.; Krieger, D.T.","year":"1980","unstructured":"Aronin N, Krieger DT. Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment. N EtzglJ Med 1980;302:453-5.","journal-title":"N EtzglJ Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2265.1984.tb00061.x","article-title":"Corticotrophin releasing factor: responses in normal subjects and patients with disorders of the hypothalamus and pituitary","volume":"20","author":"Lytras, N.; Grossman, A.; Perry, L.","year":"1984","unstructured":"Lytras N, Grossman A, Perry L, et al. Corticotrophin releasing factor: responses in normal subjects and patients with disorders of the hypothalamus and pituitary. Clin Endocrinol 1984;20:71-84.","journal-title":"Clin Endocrinol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/jcem-58-3-458","article-title":"Serotinergic stimulation of adrenocorticotrophin secretion in man","volume":"58","author":"Lewis, D.A.; Sherman, B.M.","year":"1984","unstructured":"Lewis DA, Sherman BM. Serotinergic stimulation of adrenocorticotrophin secretion in man. J Clin Endocrinol Metab 1984;58:458-62.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2265.1984.tb00068.x","article-title":"The effect of ketanserin, a specific serotonin antagonist, on the PRL, GH, ACTH and cortisol responses to hypoglycaemia in normal subjects","volume":"20","author":"Prescott, R.W.G.; Kendall Taylor, P.; Weightman, D.R.; Watson, J.M.; Ratcliffe, W.A.","year":"1984","unstructured":"Prescott RWG, Kendall Taylor P, Weightman DR, Watson JM, Ratcliffe WA. The effect of ketanserin, a specific serotonin antagonist, on the PRL, GH, ACTH and cortisol responses to hypoglycaemia in normal subjects. 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