{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:51:48Z","timestamp":1765407108159,"version":"3.46.0"},"reference-count":6,"publisher":"BMJ","issue":"6450","license":[{"start":{"date-parts":[[1984,10,13]],"date-time":"1984-10-13T00:00:00Z","timestamp":466473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,10,13]]},"abstract":"<jats:p>An Italian woman with classic active progressive systemic sclerosis had a normal serum concentration of C reactive protein (less than 6 mg\/1). During an infection with Staphylococcus aureus, however, the concentration rose to 250 mg\/1. This was unexpected, since in scleroderma the acute phase response to infection (a brisk rise in serum concentrations of various proteins, including C reactive) has been thought to be defective. This patient is evidence that the acute phase response does occur in systemic sclerosis and that probably it is the nature of the primary disease that masks the response in some cases.<\/jats:p>","DOI":"10.1136\/bmj.289.6450.946","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"946-947","source":"Crossref","is-referenced-by-count":3,"title":["\"Normal\" acute phase response in systemic sclerosis."],"prefix":"10.1136","volume":"289","author":[{"given":"M","family":"Chellingsworth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Crockson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0140-6736(81)91565-8","article-title":"C reactive protein 50 years on","volume":"ii:","author":"Pepys, M.B.","year":"1981","unstructured":"Pepys MB. 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Ann NY Acad Sci 1982;389:482-5.","journal-title":"Ann NY Acad Sci; reactive protein and the plasma protein response to tissue injury"},{"key":"ref_5","first-page":"113","article-title":"Interleukin 1 production by mononuclear cells from patients with scleroderma syndromes","volume":"28","author":"Sandborg, C.I.; Berman, M.; Andrews, B.; Friou, G.J.","year":"1983","unstructured":"Sandborg CI, Berman M, Andrews B, Friou GJ. Interleukin 1 production by mononuclear cells from patients with scleroderma syndromes. Arthritis Rheum 1983;28 (suppl):113.","journal-title":"Arthritis Rheum"},{"article-title":"Accepted","year":"1984","key":"ref_6","unstructured":"(Accepted 20 July 1984)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6450.946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6450.946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T22:49:26Z","timestamp":1765406966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6450.946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10,13]]},"references-count":6,"journal-issue":{"issue":"6450","published-online":{"date-parts":[[1984,10,13]]},"published-print":{"date-parts":[[1984,10,13]]}},"alternative-id":["10.1136\/bmj.289.6450.946"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6450.946","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,10,13]]}}}