{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:43:37Z","timestamp":1776897817075,"version":"3.51.2"},"reference-count":8,"publisher":"BMJ","issue":"6457","license":[{"start":{"date-parts":[[1984,12,1]],"date-time":"1984-12-01T00:00:00Z","timestamp":470707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,12,1]]},"abstract":"<jats:p>Twenty five patients with primary biliary cirrhosis were studied for vitamin A state. In nine patients found to have low circulating vitamin A concentrations no abnormality was found on electro-oculography or in dark adaptation. A positive correlation was found between retinol binding protein and vitamin A values (r = +0.88; p less than 0.001) and between serum albumin and vitamin A values (r = +0.75; p less than 0.001). A weaker and negative correlation was found between serum bilirubin (r = -0.47; p less than 0.05) and vitamin A values. Patients with primary biliary cirrhosis should not receive regular parenteral or even oral vitamin A supplementation unless dark adaptometry or electrooculography yields an abnormal result.<\/jats:p>","DOI":"10.1136\/bmj.289.6457.1484","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1484-1485","source":"Crossref","is-referenced-by-count":23,"title":["Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state."],"prefix":"10.1136","volume":"289","author":[{"given":"A N","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Bedford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Bouchier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.7326\/0003-4819-88-5-622","article-title":"Vitamin A reversal of abnormal dark adaptation in cirrhosis","volume":"88","author":"Russell, R.; Morrison, S.; Smith, F.; Oaks, E.; Carney, E.","year":"1978","unstructured":"Russell R, Morrison S, Smith F, Oaks E, Carney E. Vitamin A reversal of abnormal dark adaptation in cirrhosis. Ann Intern Med 1978;88:622-6.","journal-title":"Ann Intern Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/hep.1840010412","article-title":"Vitamin A and zinc therapy in primary biliary cirrhosis","volume":"1","author":"Herlong, H.; Russell, R.; Maddrey, W.","year":"1981","unstructured":"Herlong H, Russell R, Maddrey W. Vitamin A and zinc therapy in primary biliary cirrhosis. Hepatology 1981;1:348-51.","journal-title":"Hepatology"},{"key":"ref_3","first-page":"63","article-title":"Primary biliary cirrhosis: critical evaluation and treatment policies","volume":"77","author":"Sherlock, S.","year":"1982","unstructured":"Sherlock S. Primary biliary cirrhosis: critical evaluation and treatment policies. Scand J Gastroenterol 1982;suppl 77:63-74.","journal-title":"Scand J Gastroenterol"},{"key":"ref_4","first-page":"1030","article-title":"Vitamin A treatment for night blindness in primary biliary cirrhosis","volume":"288","author":"Walt, R.P.; Kemp, C.M.; Lyness, L.; Bird, A.C.; Sherlock, S.","year":"1984","unstructured":"Walt RP, Kemp CM, Lyness L, Bird AC, Sherlock S. Vitamin A treatment for night blindness in primary biliary cirrhosis. Br MedJ7 1984;288:1030-1."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000182425","article-title":"Plasma retinol and retinol binding protein concentration in patients on maintenance haemodialysis with and without vitamin A supplements","volume":"30","author":"Stewart, W.K.; Fleming, L.W.","year":"1982","unstructured":"Stewart WK, Fleming LW. Plasma retinol and retinol binding protein concentration in patients on maintenance haemodialysis with and without vitamin A supplements. Nephron 1982;30:15-21.","journal-title":"Nephron"},{"key":"ref_6","article-title":"Accepted 12","year":"1984","unstructured":"(Accepted 12 September 1984)"},{"key":"ref_7","article-title":"In an attempt to elucidate some of the factors that may be important in the development of peritonitis we have carried out a survey on the methods of the exchange technique used by our patients and their association with the development of peritonitis","unstructured":"In an attempt to elucidate some of the factors that may be important in the development of peritonitis we have carried out a survey on the methods of the exchange technique used by our patients and their association with the development of peritonitis."},{"key":"ref_8","article-title":"At the beginning of December 1982 all 97 patients who were being treated by continuous ambulatory peritoneal dialysis and were free of peritonitis were sent a questionnaire. Replies from 94 patients were received. All patients who subsequently joined the treatment programme over the next five months were also given the questionnaire. The questionnaire consisted of two parts (see Appendix). Questions in the first part asked about general hygiene and methods used in the exchange technique, and the second part asked about problems that had occurred in the previous two weeks","unstructured":"At the beginning of December 1982 all 97 patients who were being treated by continuous ambulatory peritoneal dialysis and were free of peritonitis were sent a questionnaire. Replies from 94 patients were received. All patients who subsequently joined the treatment programme over the next five months were also given the questionnaire. The questionnaire consisted of two parts (see Appendix). Questions in the first part asked about general hygiene and methods used in the exchange technique, and the second part asked about problems that had occurred in the previous two weeks."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6457.1484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6457.1484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:17:59Z","timestamp":1765408679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6457.1484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,1]]},"references-count":8,"journal-issue":{"issue":"6457","published-online":{"date-parts":[[1984,12,1]]},"published-print":{"date-parts":[[1984,12,1]]}},"alternative-id":["10.1136\/bmj.289.6457.1484"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6457.1484","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,12,1]]}}}