{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:31:39Z","timestamp":1765409499546,"version":"3.46.0"},"reference-count":18,"publisher":"BMJ","issue":"6458","license":[{"start":{"date-parts":[[1984,12,8]],"date-time":"1984-12-08T00:00:00Z","timestamp":471312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,12,8]]},"abstract":"<jats:p>Granulocyte functions including leucocyte locomotion and chemoluminescence were studied in three generations of a family in which all male members had presented with recurrent pyoderma. While parameters of humoral immunity including serum concentrations of IgG, IgA, IgM, and IgE and of complement components C3 and C4 as well as the response of mononuclear leucocytes to mitogens proved to be within the normal range, leucocyte locomotion was found to be severely impaired in all affected subjects. Moreover, granulocyte dysfunction in male members was associated with the occurrence of a single haplotype (HLA-A2, B13, DR7). These findings suggest that the defect in leucocyte locomotion and the pyoderma might not only have been inherited in an X linked manner but might also have been linked to a gene within the inherited HLA haplotype.<\/jats:p>","DOI":"10.1136\/bmj.289.6458.1561","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1561-1563","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent pyoderma in a family with a defect in leucocyte locomotion."],"prefix":"10.1136","volume":"289","author":[{"given":"C C","family":"Zielinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Dremsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,12,8]]},"reference":[{"key":"ref_1","first-page":"59","article-title":"Pathology of chemotaxis and random mobility","volume":"12","author":"Miller, M.E.","year":"1975","unstructured":"Miller ME. Pathology of chemotaxis and random mobility. Semin Hematol 1975;12:59-82.","journal-title":"Semin Hematol"},{"key":"ref_2","first-page":"307","article-title":"Clinical manifestations of disorders of neutrophil chemotaxis","author":"Quie, P.G.; Cates, R.L.","year":"1978","unstructured":"Quie PG, Cates RL. Clinical manifestations of disorders of neutrophil chemotaxis. In: Gallin JI, Quie PG, eds. Leukocyte chemotaxis. New York: Raven Press, 1978:307-28."},{"key":"ref_3","first-page":"329","article-title":"Disorders of granulocyte chemotaxis","author":"Clark, R.A.","year":"1978","unstructured":"Clark RA. Disorders of granulocyte chemotaxis. In: Gallin JI, Quie PG, eds. Leukocyte chemotaxis. New York: Raven Press, 1978:329-56."},{"key":"ref_4","first-page":"665","article-title":"Lazy-leukocyte syndrome: a new disorder of neutrophil function","volume":"i:","author":"Miller, M.E.; Oski, F.A.; Harris, M.B.","year":"1971","unstructured":"Miller ME, Oski FA, Harris MB. Lazy-leukocyte syndrome: a new disorder of neutrophil function. Lancet 1971;i:665-9.","journal-title":"Lancet"},{"key":"ref_5","first-page":"2645","article-title":"Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. Jf CGin Ivest","volume":"50","author":"Clark, R.A.; Kimball, H.R.","year":"1971","unstructured":"Clark RA, Kimball HR. Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. Jf CGin Ivest 1971;50:2645-52."},{"key":"ref_6","first-page":"617","article-title":"Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent \"cold\" staphylococcal abscesses","volume":"ii:","author":"Hill, H.R.; Ochs, H.D.; Quie, P.G.; Pabst, H.F.; Klebanoff, S.J.; Wedgwood, R.J.","year":"1974","unstructured":"Hill HR, Ochs HD, Quie PG, Pabst HF, Klebanoff SJ, Wedgwood RJ. Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent \"cold\" staphylococcal abscesses. Lancet 1974;ii:617-9.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(74)92493-3","article-title":"Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections","volume":"i:","author":"Hill, H.R.; Quie, P.G.","year":"1974","unstructured":"Hill HR, Quie PG. Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet 1974;i: 183-7.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes","volume":"115","author":"Boyden, S.","year":"1962","unstructured":"Boyden S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J Exp Med 1962;115:453-66.","journal-title":"J Exp Med"},{"key":"ref_9","first-page":"357","article-title":"Chemotaxis of polymorphonuclears in vitro","volume":"6","author":"Frei, P.C.; Baisero, M.H.; Ochsner, M.","year":"1974","unstructured":"Frei PC, Baisero MH, Ochsner M. Chemotaxis of polymorphonuclears in vitro. 7 Immunol Methods 1974;6:357-86.","journal-title":"7 Immunol Methods"},{"key":"ref_10","first-page":"65","article-title":"Mechanisms of leukocyte locomotion in hemophilia","volume":"11","author":"Zielinski, C.C.; Ahmad, R.; Endler, A.T.; Eibl, M.M.","year":"1980","unstructured":"Zielinski CC, Ahmad R, Endler AT, Eibl MM. Mechanisms of leukocyte locomotion in hemophilia. 7 Med 1980;11:65-78.","journal-title":"7 Med"},{"key":"ref_11","first-page":"153","article-title":"Comparison of phagocytic and chemoluminescence response Lab","volume":"89","author":"Grebner, J.V.; Mills, E.L.; Gray, B.H.; Quie, P.G.","year":"1977","unstructured":"Grebner JV, Mills EL, Gray BH, Quie PG. Comparison of phagocytic and chemoluminescence response Lab ClGn Med 1977;89:153-9.","journal-title":"ClGn Med"},{"key":"ref_12","first-page":"133","article-title":"Experimental immunochemistry","author":"Mayer, M.M.","year":"1961","unstructured":"Mayer MM. Experimental immunochemistry. 2nd ed. Springfield: CC Thomas, 1961:133-240.","edition":"2nd ed"},{"key":"ref_13","first-page":"97","article-title":"Isolation of mononuclear cells and granulocytes from human blood: isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation","volume":"21","author":"Boyum, A.","year":"1968","unstructured":"Boyum A. Isolation of mononuclear cells and granulocytes from human blood: isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest 1968;21(suppl 97):77-89.","journal-title":"Scand J Clin Lab Invest"},{"key":"ref_14","first-page":"939","article-title":"Intrinsic defect of the polymorphonuclear leukocyte resulting in impaired chemotaxis and phagocytosis","volume":"9","author":"Steerman, R.L.; Snyderman, R.; Leiken, S.L.; Colten, H.R.","year":"1971","unstructured":"Steerman RL, Snyderman R, Leiken SL, Colten HR. Intrinsic defect of the polymorphonuclear leukocyte resulting in impaired chemotaxis and phagocytosis. Clin Exp Immunol 1971;9:939-46.","journal-title":"Clin Exp Immunol"},{"key":"ref_15","first-page":"227","article-title":"Abnormal chemotaxis: cellular and humoral components","volume-title":"The phagocytic cell in host resistance","author":"Gallin, J.I.","year":"1975","unstructured":"Gallin JI. Abnormal chemotaxis: cellular and humoral components. In: Bellanti JA, Dayton DH, eds. The phagocytic cell in host resistance. New York: Raven Press, 1975:227-48."},{"key":"ref_16","first-page":"209","article-title":"A unique leukocyte dysfunction associated with decreased resistance to infection","volume":"18","author":"Higgins, G.R.; Swanson, V.; Granulocytasthenia, Yamazaki J.","year":"1970","unstructured":"Higgins GR, Swanson V, Yamazaki J. Granulocytasthenia. A unique leukocyte dysfunction associated with decreased resistance to infection. Clin Res 1970; 18:209.","journal-title":"Clin Res"},{"key":"ref_17","first-page":"617","article-title":"Polymorphonuclear leukocyte chemotaxis in patients with bacterial infections","volume":"iii:","author":"Mowat, A.G.; Baum, J.","year":"1971","unstructured":"Mowat AG, Baum J. Polymorphonuclear leukocyte chemotaxis in patients with bacterial infections. 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