{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:04:00Z","timestamp":1772222640547,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","issue":"6458","license":[{"start":{"date-parts":[[1984,12,8]],"date-time":"1984-12-08T00:00:00Z","timestamp":471312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,12,8]]},"abstract":"<jats:p>A diabetic man with no previous history of allergy began to suffer itchy, painful swelling at the sites of injection after three months' treatment with bovine insulin. Insulin specific IgE concentrations (1.2-2.0 U\/ml) were higher than in non-allergic diabetics (mean 0.4 (SD 0.06) U\/ml) but lower than in most other patients allergic to insulin (1.0-19.0 U\/ml). Standard approaches failed to overcome the allergic reaction, and four separate attempts at desensitisation were unsuccessful. The patient was then given oral insulin 800 U thrice daily together with enteric coated aspirin 1300 mg thrice daily for one week, and subsequent desensitisation with neutral insulin injection was carried out successfully. On stopping the aspirin the original reactions returned, and aspirin was therefore reinstituted as a permanent part of treatment. Whatever the mechanism in this patient, oral desensitisation and aspirin provided a simple method for treating a difficult condition.<\/jats:p>","DOI":"10.1136\/bmj.289.6458.1565","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1565-1566","source":"Crossref","is-referenced-by-count":10,"title":["Cutaneous insulin allergy responsive to oral desensitisation and aspirin."],"prefix":"10.1136","volume":"289","author":[{"given":"I M","family":"Holdaway","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0025-7125(16)31764-3","article-title":"Insulin treatment in diabetes","volume":"62","author":"Galloway, J.A.; Bressler, R.","year":"1978","unstructured":"Galloway JA, Bressler R. Insulin treatment in diabetes. Med ClGn North Am 1978;62:663-71.","journal-title":"Med ClGn North Am"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF00281301","article-title":"Determination of insulin specific IgE in serum of diabetic patients by solid-phase radioimmunoassay","volume":"22","author":"Falholt, K.","year":"1982","unstructured":"Falholt K. Determination of insulin specific IgE in serum of diabetic patients by solid-phase radioimmunoassay. Diabetologia 1982;22:254-7.","journal-title":"Diabetologia"},{"key":"ref_3","first-page":"491","article-title":"Management of insulin allergy and resistance","volume":"33","author":"Elenbaas, R.M.; Forni, P.J.","year":"1976","unstructured":"Elenbaas RM, Forni PJ. Management of insulin allergy and resistance. AmJ Hosp Pharm 1976;33:491-7.","journal-title":"AmJ Hosp Pharm"},{"key":"ref_4","first-page":"1106","article-title":"Allergic reactions to insulin","volume-title":"J7AMA","volume":"215","author":"Leiberman, P.; Patterson, R.; Metz, R.; Lucena, J.","year":"1971","unstructured":"Leiberman P, Patterson R, Metz R, Lucena J. Allergic reactions to insulin. J7AMA 1971;215:1106-12."},{"key":"ref_5","article-title":"Accepted 10","year":"1984","unstructured":"(Accepted 10 October 1984)"},{"key":"ref_6","article-title":"For over a century rubella (or German measles) was considered to be a mild disease. Then in 1941 the intrauterine effects of rubella were recognised.' By 1943 maternal rubella during pregnancy was documented as being associated with deafness, blindness, heart disease, and other congenital malformations among infants.2 In 1969 Cooper et al3 estimated that the incidence of fetal damage after maternal infection in the first trimester of pregnancy was \"in excess of 20%.\"3 These results were confirmed by Miller et al,4 but the numbers in their study were small","unstructured":"For over a century rubella (or German measles) was considered to be a mild disease. Then in 1941 the intrauterine effects of rubella were recognised.' By 1943 maternal rubella during pregnancy was documented as being associated with deafness, blindness, heart disease, and other congenital malformations among infants.2 In 1969 Cooper et al3 estimated that the incidence of fetal damage after maternal infection in the first trimester of pregnancy was \"in excess of 20%.\"3 These results were confirmed by Miller et al,4 but the numbers in their study were small."},{"key":"ref_7","article-title":"Buimovici-Klien et al showed that lymphocyte transformation after stimulation with phytohaemagglutinin was significantly lower in children with congenital rubella than in healthy controls.7 Specific lymphocyte responses to purified rubella virus were absent or at least two times lower in children with congenital rubella than in immune controls. In 1981 workers at this laboratory investigated these claims. The results obtained led to the development of a useful diagnostic test, using readily available reagents, to measure the immunological responses to rubella virus antigens in vitro.,'","volume-title":"Lymphocytes","author":"In","year":"1979","unstructured":"In 1979 Buimovici-Klien et al showed that lymphocyte transformation after stimulation with phytohaemagglutinin was significantly lower in children with congenital rubella than in healthy controls.7 Specific lymphocyte responses to purified rubella virus were absent or at least two times lower in children with congenital rubella than in immune controls. In 1981 workers at this laboratory investigated these claims. The results obtained led to the development of a useful diagnostic test, using readily available reagents, to measure the immunological responses to rubella virus antigens in vitro.,' Lymphocytes from"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6458.1565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6458.1565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:22:41Z","timestamp":1765408961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6458.1565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,8]]},"references-count":7,"journal-issue":{"issue":"6458","published-online":{"date-parts":[[1984,12,8]]},"published-print":{"date-parts":[[1984,12,8]]}},"alternative-id":["10.1136\/bmj.289.6458.1565"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6458.1565","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,12,8]]}}}