{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:31:43Z","timestamp":1765409503811,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"6458","license":[{"start":{"date-parts":[[1984,12,8]],"date-time":"1984-12-08T00:00:00Z","timestamp":471312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1984,12,8]]},"abstract":"<jats:p>Sixty nine propositi from a family study of coeliac disease were typed for HLA-DR antigens. Sixty three (91%) were found to carry the antigen DR3, which was a significantly greater proportion (p = 9.6 X 10(-24] than among the 168 controls (26%). Concurrently 42 children with the disease were DR typed. Not only was the frequency of DR3 significantly increased in these patients (86% versus 26% in controls; p = 3.1 X 10(-12] but so also was the frequency of DR7 (patients 60%, controls 29%; p = 5.8 X 10(-4]. When those propositi whose coeliac disease presented before the age of 20 were combined with the childhood coeliac group and a comparison made between these patients and the remainder of the propositi, all of whom presented when they were older than 20, the childhood onset group had a significant excess of DR7 (p = 2.2 X 10(-3] and a significant deficiency of DR2 (p = 3.5 X 10(-3]. These findings indicate that childhood coeliac disease and adult coeliac disease are genetically heterogeneous.<\/jats:p>","DOI":"10.1136\/bmj.289.6458.1571","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1571-1573","source":"Crossref","is-referenced-by-count":15,"title":["HLA-DR typing in coeliac disease: evidence for genetic heterogeneity."],"prefix":"10.1136","volume":"289","author":[{"given":"A","family":"Ellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dillon-Remmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Woodrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"McConnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1984,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/00365527809181753","article-title":"Strong association between HLA-DW3 related B-cell alloantigen-DRW3 and coeliac disease","volume":"13","author":"Ek, J.; Albrechsten, D.; Solheim, B.G.; Thorsby, E.","year":"1978","unstructured":"Ek J, Albrechsten D, Solheim BG, Thorsby E. Strong association between HLA-DW3 related B-cell alloantigen-DRW3 and coeliac disease. Scand J Gastroenterol 1978;13:229-33.","journal-title":"Scand J Gastroenterol"},{"key":"ref_2","first-page":"143","article-title":"HLA-DR antigens in coeliac disease. A population and multiple case family study","volume-title":"The genetics of coeliac disease","author":"Scholz, S.; Rossipal, E.; Ch, Brautbar","year":"1981","unstructured":"Scholz S, Rossipal E, Brautbar Ch, et al. HLA-DR antigens in coeliac disease. A population and multiple case family study. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:143-9."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1399-0039.1979.tb00854.x","article-title":"Two HLA-D and DR antigens are associated with coeliac disease","volume":"14","author":"DeMarchi, M.; Borelli, I.; Olivetti, E.","year":"1979","unstructured":"DeMarchi M, Borelli I, Olivetti E, et al. Two HLA-D and DR antigens are associated with coeliac disease. Tissue Antigens 1979;14:309-16.","journal-title":"Tissue Antigens"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-94-011-8114-3_27","article-title":"Gluten sensitive enteropathy in Spain: genetic and environmental factors","volume-title":"The genetics of coeliac disease","author":"Polanco, I.; Biemond, I.; Van Leeuwen, A.","year":"1981","unstructured":"Polanco I, Biemond I, Van Leeuwen A, et al. Gluten sensitive enteropathy in Spain: genetic and environmental factors. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:211-31."},{"key":"ref_5","first-page":"605","article-title":"Association de la maladie coeliaque de l'adults avec HLA-DRW3 et DRW7. Gastroenterol ClGn Biol","volume":"3","author":"Betuel, H.; Gebuhrer, L.; Percebois, H.; Descos, L.; Minaire, Y.; Bertrand, J.","year":"1979","unstructured":"Betuel H, Gebuhrer L, Percebois H, Descos L, Minaire Y, Bertrand J. Association de la maladie coeliaque de l'adults avec HLA-DRW3 et DRW7. Gastroenterol ClGn Biol 1979;3:605-6."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/gut.24.4.306","article-title":"HLA antigens and atopy in children with coeliac disease","volume":"24","author":"Verkasalo, M.; Tilikainen, A.; Kuitunen, P.; Savilahti, E.; Backman, A.","year":"1983","unstructured":"Verkasalo M, Tilikainen A, Kuitunen P, Savilahti E, Backman A. HLA antigens and atopy in children with coeliac disease. Gut 1983;24:306-10.","journal-title":"Gut"},{"key":"ref_7","first-page":"153","article-title":"B-cell alloantigens associated with coeliac disease in the west of Ireland","volume-title":"The genetics of coeliac disease","author":"McKenna, R.; Stevens, F.M.; Bourke, M.; McNicholl, B.; Albert, E.D.; McCarthy, C.F.","year":"1981","unstructured":"McKenna R, Stevens FM, Bourke M, McNicholl B, Albert ED, McCarthy CF. B-cell alloantigens associated with coeliac disease in the west of Ireland. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:153-8."},{"key":"ref_8","first-page":"161","article-title":"DR locus-controlled B-cell alloantigens in coeliac disease in the Netherlands","volume-title":"The genetics of coeliac disease","author":"Pena, A.S.; Biemond, I.; Rosekrans, P.C.M.; Van Leeuwen, A.; Schreuder, I.; Van Rood, J.J.","year":"1981","unstructured":"Pena AS, Biemond I, Rosekrans PCM, Van Leeuwen A, Schreuder I, Van Rood JJ. DR locus-controlled B-cell alloantigens in coeliac disease in the Netherlands. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:161-8."},{"key":"ref_9","first-page":"265","article-title":"Liverpool coeliac family study","volume-title":"The genetics of coeliac disease","author":"Ellis, A.; Evans, D.A.P.; McConnell, R.B.; Woodrow, J.C.","year":"1981","unstructured":"Ellis A, Evans DAP, McConnell RB, Woodrow JC. Liverpool coeliac family study. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:265-86."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1651-2227.1970.tb15545.x","article-title":"Diagnostic criteria in coeliac disease. (Discussion European Society for Paediatric Gastroenterology.)","volume":"59","author":"Meeuwisse, S.G.W.","year":"1970","unstructured":"Meeuwisse SGW. Diagnostic criteria in coeliac disease. (Discussion European Society for Paediatric Gastroenterology.) Acta Paediatr Scand 1970;59:461-5.","journal-title":"Acta Paediatr Scand"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/262795a0","article-title":"Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants","volume":"262","author":"JJ, Van Rood; van Leeuwen A; JS, Ploem","year":"1976","unstructured":"Van Rood JJ, van Leeuwen A, Ploem JS. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Nature 1976;262:795-7.","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0090-1229(83)90106-X","article-title":"Evidence that coeliac disease is primarily associated with a DC locus allelic specificity","volume":"28","author":"Tosi, R.; Vismara, D.; Tanigaki, N.","year":"1983","unstructured":"Tosi R, Vismara D, Tanigaki N, et al. Evidence that coeliac disease is primarily associated with a DC locus allelic specificity. Clin Immunol Immunopathol 1983;28:395-404.","journal-title":"Clin Immunol Immunopathol"},{"article-title":"DR3 and DR7 negative coeliac disease","author":"M, De Marchi; AO, Carbonara","key":"ref_13","unstructured":"De Marchi M, Carbonara AO. DR3 and DR7 negative coeliac disease. In: Albert E, Mayr WR, ed. Histocompatibility testing. Heidelberg: Springer Verlag. (in press)."},{"key":"ref_14","first-page":"173","article-title":"The relationship of HLA-A, B status to the clinical findings and autoimmunity in coeliac disease","volume-title":"The genetics of coeliac disease","author":"Kumar, P.; Oliver, R.T.D.; O'Donoghue, D.P.","year":"1981","unstructured":"Kumar P, Oliver RTD, O'Donoghue DP, et al. The relationship of HLA-A, B status to the clinical findings and autoimmunity in coeliac disease. In: McConnell RB, ed. The genetics of coeliac disease. Lancaster: MTP Press Ltd, 1981:173-80."},{"article-title":"Accepted 26","year":"1984","key":"ref_15","unstructured":"(Accepted 26 September 1984)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.289.6458.1571","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.289.6458.1571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T23:22:52Z","timestamp":1765408972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.289.6458.1571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,8]]},"references-count":15,"journal-issue":{"issue":"6458","published-online":{"date-parts":[[1984,12,8]]},"published-print":{"date-parts":[[1984,12,8]]}},"alternative-id":["10.1136\/bmj.289.6458.1571"],"URL":"https:\/\/doi.org\/10.1136\/bmj.289.6458.1571","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1984,12,8]]}}}