{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:20:59Z","timestamp":1765542059422,"version":"3.48.0"},"reference-count":18,"publisher":"BMJ","issue":"6461","license":[{"start":{"date-parts":[[1985,1,5]],"date-time":"1985-01-05T00:00:00Z","timestamp":473731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,1,5]]},"abstract":"<jats:p>Fifteen splenectomised and 15 normal subjects were studied, in absence of any intentional immunisation, for pokeweed mitogen induced synthesis of antipneumococcal capsular polysaccharide antibodies in vitro by peripheral blood mononuclear cells. Results showed that removal of the spleen had caused a persistent immune deficiency of circulating B cells capable of synthesising IgM antipneumococcal capsular polysaccharide. In vitro synthesis of polyclonal IgM and IgG by peripheral blood mononuclear cells of subjects without spleens was also depressed. These defects were due to an abnormality of the B cell compartment. These data are evidence of the major role of the spleen in the control and production of a consistent part of pokeweed mitogen responsive circulating B cells and add another facet to the complex immune dysfunction of splenectomised subjects. The findings, moreover, may help in understanding the susceptibility of splenectomised people to pneumococcal sepsis and the delayed and impaired antibody response to pneumococcal vaccine.<\/jats:p>","DOI":"10.1136\/bmj.290.6461.14","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"14-16","source":"Crossref","is-referenced-by-count":31,"title":["Impaired antipneumococcal antibody production in patients without spleens."],"prefix":"10.1136","volume":"290","author":[{"given":"F","family":"Di Padova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"D\u00fcrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Harder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Di Padova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Zanussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,1,5]]},"reference":[{"issue":"3","key":"ref_1","first-page":"184","article-title":"Assessment of the antibody response to pneumococcal vaccine in high-risk populations","volume":"1981","author":"Landesman, S.H.; Schiffman, G.","unstructured":"Landesman SH, Schiffman G. Assessment of the antibody response to pneumococcal vaccine in high-risk populations. Rev Infect Dis 1981;suppl 3:184-96.","journal-title":"Rev Infect Dis"},{"key":"ref_2","first-page":"127","article-title":"Splenectomy and subsequent mortality in veterans of the 1939-45 war","volume":"ii:","author":"Robinette, C.D.; Fraumeni, J.F.","year":"1977","unstructured":"Robinette CD, Fraumeni JF. Splenectomy and subsequent mortality in veterans of the 1939-45 war. 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Lanicet 1978;i:178-81.","journal-title":"Br Med J"},{"key":"ref_9","first-page":"245","article-title":"Opsonic requirements for intravascular clearance after splenectomy. N Engl J'","volume":"304","author":"Hosea, S.W.; Brown, E.J.; Hamburger, M.I.; Frank, M.M.","year":"1981","unstructured":"Di Padova F, Durig M, Wadstrom J, Harder F. Role of spleen in immune response to polyvalent pneumococcal vaccine. Br Med J 1983;287:1829-32.","journal-title":"Med"},{"key":"ref_10","first-page":"11","article-title":"IgM and IgG response to pneumococcal polysaccharide vaccine in normal individuals and individuals splenectomized due to trauma","volume":"92","author":"Aaberge, I.S.; Heier, H.E.; Hem, E.; Giercksky, K.E.; Groeng, E.C.","year":"1984","unstructured":"Hosea SW, Brown EJ, Hamburger MI, Frank MM. Opsonic requirements for intravascular clearance after splenectomy. N Engl J' Med 1981;304:245-50.","journal-title":"Acta Pathol Microbiol Inzmunol Scand [C]"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI111341","article-title":"Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans","volume":"73","author":"Kodo, H.; Gale, R.P.; Saxon, A.","year":"1984","unstructured":"Aaberge IS, Heier HE, Hem E, Giercksky KE, Groeng EC. IgM and IgG response to pneumococcal polysaccharide vaccine in normal individuals and individuals splenectomized due to trauma. Acta Pathol Microbiol Inzmunol Scand [C] 1984;92:11-6.","journal-title":"J Clin Invest"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1172\/JCI110926","article-title":"Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia","volume":"71","author":"Yarchoan, R.; Schneider, H.S.; Wray, B.B.; Nelson, D.L.","year":"1983","unstructured":"Kodo H, Gale RP, Saxon A. Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans. J Clin Invest 1984;73:1377-84.","journal-title":"J Clin Invest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.132.1.191","article-title":"Alterations in immunoglobulin synthesis by peripheral blood mononuclear cells from splenectomized patients with and without splenic regrowth","volume":"132","author":"Drew, P.A.; Kiroff, G.K.; Ferrante, A.; Cohen, R.C.","year":"1984","unstructured":"Yarchoan R, Schneider HS, Wray BB, Nelson DL. Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia. 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Eur3 Immnunol 1981;11:858-64."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.290.6461.14","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.290.6461.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:16:38Z","timestamp":1765541798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.290.6461.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1,5]]},"references-count":18,"journal-issue":{"issue":"6461","published-online":{"date-parts":[[1985,1,5]]},"published-print":{"date-parts":[[1985,1,5]]}},"alternative-id":["10.1136\/bmj.290.6461.14"],"URL":"https:\/\/doi.org\/10.1136\/bmj.290.6461.14","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1985,1,5]]}}}