{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:35:34Z","timestamp":1765542934628,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"6463","license":[{"start":{"date-parts":[[1985,1,19]],"date-time":"1985-01-19T00:00:00Z","timestamp":474940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,1,19]]},"abstract":"<jats:p>A study was conducted of the response of the pituitary-testicular axis to two different methods of administration of the luteinising hormone releasing hormone (LHRH) analogue ICI 118630 (Zoladex) in patients with prostatic cancer. The analogue was given by continuous infusion to four previously untreated patients with prostatic cancer for 60 days (group 1). Subsequently a further four patients were given a depot formulation of the same analogue by subcutaneous injection once every 28 days (group 2). Both methods of administration produced similar, successful suppression of luteinising hormone (LH) associated with a reduction of testosterone to castrate concentrations. The median basal testosterone concentrations before treatment in groups 1 and 2 were 20.6 and 14.1 nmol\/l (5.94 and 4.07 ng\/ml) respectively; these were reduced to 1.4 and 1.1 nmol\/l (0.40 and 0.32 ng\/ml) within four weeks of the start of treatment. The median basal LH concentration in groups 1 and 2 were 7.9 and 16.6 IU\/1 respectively, which were suppressed to 2.6 and 2.4 IU\/1 by four weeks. The suppression of LH and testosterone was maintained with continuous subcutaneous infusion for up to 60 days in group 1, and by subsequent injections of the depot every 28 days in group 2. The use of depot preparation of an LHRH analogue to suppress gonadotrophin and sex hormone secretion offers the convenience of once monthly injections when LHRH analogues are required for the long term treatment of elderly patients with prostatic cancer and children with precocious puberty.<\/jats:p>","DOI":"10.1136\/bmj.290.6463.185","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"185-187","source":"Crossref","is-referenced-by-count":48,"title":["Preliminary report on use of depot formulation of LHRH analogue ICI 118630 (Zoladex) in patients with prostatic cancer."],"prefix":"10.1136","volume":"290","author":[{"given":"S R","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Shalet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Weatherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J","family":"Blacklock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,1,19]]},"reference":[{"key":"ref_1","first-page":"415","article-title":"Treatment of advanced prostatic cancer with LHRH-analogue ICI 118630: clinical response and hormonal mechanisms","volume":"ii:","author":"Ahmed, SR, Brooman; PJC, Shalet; SM, Howell; A, Blacklock; N.J.","year":"1983","unstructured":"Ahmed SR, Brooman PJC, Shalet SM, Howell A, Blacklock NJ. Treatment of advanced prostatic cancer with LHRH-analogue ICI 118630: clinical response and hormonal mechanisms. Lancet 1983;ii:415-8.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1136\/bmj.286.6378.1607","article-title":"Advanced carcinoma of the prostate: treatment with gonadotrophin releasing hormone agonist","volume":"286","author":"Allen, J.M.; O'Shea, J.P.; Mashiter, K.; Williams, G.R.; Bloom, SR","year":"1983","unstructured":"Allen JM, O'Shea JP, Mashiter K, Williams GR, Bloom SR. Advanced carcinoma of the prostate: treatment with gonadotrophin releasing hormone agonist. Br Med y 1983;286:1607-9.","journal-title":"Br Med y"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/bmj.286.6374.1309","article-title":"Treatment with gonadotrophin releasing hormone analogue in advanced prostatic cancer","volume":"286","author":"Waxman, J.H.; Wass, J.A.H.; W'F, Hendry","year":"1983","unstructured":"Waxman JH, Wass JAH, Hendry W'F, et al. Treatment with gonadotrophin releasing hormone analogue in advanced prostatic cancer. Br Med Y 1983; 286:1309-12.","journal-title":"Br Med Y"},{"issue":"6","key":"ref_4","first-page":"1408","article-title":"Therapeutic potential of the LH-RH agonist Zoladex (ICI 118630) in the treatment of advanced breast cancer in preand postmenopausal women. Abstracts of satellite symposium of the 7th international congress of endocrinology","volume":"20","author":"Walker, K.J.; Nicholson, R.I.; Turkes, A.; Plowman, N.; Blamey, R.","year":"1984","unstructured":"Walker KJ, Nicholson RI, Turkes A, Plowman N, Blamey R. Therapeutic potential of the LH-RH agonist Zoladex (ICI 118630) in the treatment of advanced breast cancer in preand postmenopausal women. Abstracts of satellite symposium of the 7th international congress of endocrinology. 7 Steroid Biochem 1984;20(6B):1408. (Abstract A90.)","journal-title":"7 Steroid Biochem"},{"issue":"6","key":"ref_5","first-page":"1381","article-title":"Therapy of precocious puberty: LHRH analogue effects on pubertal growth and maturation. Abstracts of satellite symposium of the 7th international congress of endocrinology. Y7 Steroid Biochem","volume":"20","author":"Comite, F.; Pescovitz, O.H.; Hench, K.; McNemar, A.; Loriaux, D.L.; GB, Jr, Cutler","year":"1984","unstructured":"Comite F, Pescovitz OH, Hench K, McNemar A, Loriaux DL, Cutler GB Jr. Therapy of precocious puberty: LHRH analogue effects on pubertal growth and maturation. Abstracts of satellite symposium of the 7th international congress of endocrinology. Y7 Steroid Biochem 1984;20(6B):1381. (Abstract"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2265.1984.tb03433.x","article-title":"LHRH analogue in combination with cyproterone acetate-further experience","volume":"20","year":"1984","unstructured":"LHRH analogue in combination with cyproterone acetate-further experience. Clin Endocrinol (Oxf) 1984;20:377-87.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref_7","first-page":"239","article-title":"Chronic treatment with the gonadotrophinreleasing hormone agonist D-Ser (TBu)'-EA\"'-LRH for contraception in women and men. Int3'","volume":"25","author":"Nillius, S.J.; Bergquist, C.; Wide, L.","year":"1980","unstructured":"Nillius SJ, Bergquist C, Wide L. Chronic treatment with the gonadotrophinreleasing hormone agonist D-Ser (TBu)'-EA\"'-LRH for contraception in women and men. Int3' Fertil 1980;25:239-46.","journal-title":"Fertil"},{"key":"ref_8","first-page":"413","article-title":"Therapeutic potential of the LHRH agonist, ICI 118630, in the treatment of advanced prostatic carcinoma","volume":"ii:","author":"Walker, K.J.; Nicholson, R.I.; Turkes, A.O.","year":"1983","unstructured":"Walker KJ, Nicholson RI, Turkes AO, et al. Therapeutic potential of the LHRH agonist, ICI 118630, in the treatment of advanced prostatic carcinoma. Lancet 1983;ii:413-5.","journal-title":"Lancet"},{"key":"ref_9","series-title":"Proceedings of the 13th internotional congress of chemotherapy. Vienna 1983","first-page":"50","article-title":"Treatment of rat mammary and prostatic tumour with the potent luteinising hormone releasing hormone (LHRH) analogue ICI 118630","author":"Furr, B.J.A.; Hutchinson, F.G.","year":"1983","unstructured":"Furr BJA, Hutchinson FG. Treatment of rat mammary and prostatic tumour with the potent luteinising hormone releasing hormone (LHRH) analogue ICI 118630. In: Proceedings of the 13th internotional congress of chemotherapy. Vienna 1983. Vienna: Verlag H Egermann, 1983:suppl:50-1."},{"key":"ref_10","article-title":"Sustained release of the LH-RH analog ICI 118630 for the treatment of hormone responsive tumours","author":"Furr, B.J.A.; Hutchinson, F.G.; Valcaccia, B.; Churchill, JR","unstructured":"Furr BJA, Hutchinson FG, Valcaccia B, Churchill JR. Sustained release of the LH-RH analog ICI 118630 for the treatment of hormone responsive tumours. Nature (in press).","journal-title":"Nature"},{"article-title":"Biodegradable polymers for the sustained release of peptides. Biochem Soc Trans","author":"Hutchinson, F.G.; Furr, B.J.A.","key":"ref_11","unstructured":"Hutchinson FG, Furr BJA. Biodegradable polymers for the sustained release of peptides. Biochem Soc Trans (in press)."},{"key":"ref_12","first-page":"1018","article-title":"A simple method for the assay of eight steroids in small volumes of plasma","volume":"28","author":"Anderson, D.C.; Hopper, B.R.; Lasley, B.L.; Yen, S.S.C.","year":"1976","unstructured":"Anderson DC, Hopper BR, Lasley BL, Yen SSC. A simple method for the assay of eight steroids in small volumes of plasma. Steroids 1976;28:1018-24.","journal-title":"Steroids"},{"issue":"7","key":"ref_13","first-page":"13","article-title":"Pituitary function after treatment of intracranial tumours in children","volume":"104","author":"Shalet, S.M.; Beardwell, C.G.; Morris Jones, P.H.; Pearson, D.","year":"1975","unstructured":"Shalet SM, Beardwell CG, Morris Jones PH, Pearson D. Pituitary function after treatment of intracranial tumours in children. Lancet 1975;ii:104-7. 13a Clayton RN, Bailey LC, Cottam J, Arkell D, Perron TJ, Blackledge GRP. Radioimmunoassay for a GnRH agonist analogue in serum of patients with prostate cancer treated with D-Ser (But)', Azgly' \u00b0-GnRH. Clin Enidocrinol (Oxf) (in press).","journal-title":"Lancet; Radioimmunoassay for a GnRH agonist analogue in serum of patients with prostate cancer treated with D-Ser (But"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/j.1879-3479.1980.tb00507.x","article-title":"LHRH agonists and antagonists","volume":"18","author":"Schally, A.V.; Coy, D.H.; Arimura, A.","year":"1980","unstructured":"Schally AV, Coy DH, Arimura A. LHRH agonists and antagonists. Int Y Gynaccol Obstet 1980;18:318-24.","journal-title":"Int Y Gynaccol Obstet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1210\/endo-105-5-1191","article-title":"Chronic effects of (D-Trp', Pro'-NEt) luteinizing hormone-releasing factor on reproductive processes in the male rat","volume":"105","author":"Rivier, C.; Rivier, J.; Vale, W.","year":"1979","unstructured":"Rivier C, Rivier J, Vale W. Chronic effects of (D-Trp', Pro'-NEt) luteinizing hormone-releasing factor on reproductive processes in the male rat. Endocrinlology 1979;105:1191-1201.","journal-title":"Endocrinlology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/endo-110-4-1308","article-title":"Inhibition of pituitarv-testicular function with (d-Trp') luteinizing hormone releasing hormone in rhesus monkeys","volume":"110","author":"Sundaram, K.; Connell, K.G.; Bardin, C.W.; Samojlik, E.; Schally, A.V.","year":"1982","unstructured":"Sundaram K, Connell KG, Bardin CW, Samojlik E, Schally AV. Inhibition of pituitarv-testicular function with (d-Trp') luteinizing hormone releasing hormone in rhesus monkeys. Endocrinology 1982;110:1308-14.","journal-title":"Endocrinology"},{"key":"ref_17","first-page":"278","article-title":"Effect of chronic treatment with a potent luteinizing hormone releasing hormone agonist on serum luteinizing hormone and steroid levels in the male rhesus monkey","volume":"26","author":"Resko, J.A.; Belanger, A.; Labrie, F.","year":"1982","unstructured":"Resko JA, Belanger A, Labrie F. Effect of chronic treatment with a potent luteinizing hormone releasing hormone agonist on serum luteinizing hormone and steroid levels in the male rhesus monkey. Biol Reprod 1982;26:278.","journal-title":"Biol Reprod"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/bmj.289.6443.468","article-title":"Failure of long term luteinising hormone releasing hormone treatment for prostatic cancer to suppress serum luteinising hormone and testosterone","volume":"289","year":"1984","unstructured":"Kerle D, \\Williams G, \\W'are H, Bloom SR. Failure of long term luteinising hormone releasing hormone treatment for prostatic cancer to suppress serum luteinising hormone and testosterone. Br AMedJA 1984;289:468-9.","journal-title":"Br AMedJA"},{"key":"ref_19","first-page":"262","article-title":"Influence of continuous gonadotrophin releasing hormone (GnRH) agonist treatment on luteinizing hormone and testosterone secretion, the response to GnRH, and the testicular response to human chorionic gonadotrophin in male rhesus monkeys. _7 Cliz Endocrinol AIetab","volume":"58","author":"Mann, D.R.; Gould, K.G.; Collins, D.C.","year":"1984","unstructured":"Mann DR, Gould KG, Collins DC. Influence of continuous gonadotrophin releasing hormone (GnRH) agonist treatment on luteinizing hormone and testosterone secretion, the response to GnRH, and the testicular response to human chorionic gonadotrophin in male rhesus monkeys. _7 Cliz Endocrinol AIetab 1984 58:262-7."},{"key":"ref_20","first-page":"179","article-title":"Effects of continuous treatment of male baboons with superagonist of LHRH","volume":"25","author":"Vickery, B.H.; McRae, G.I.","year":"1980","unstructured":"Vickery BH, McRae GI. Effects of continuous treatment of male baboons with superagonist of LHRH. Int Y Fertil 1980;25:179.","journal-title":"Int Y Fertil"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.290.6463.185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.290.6463.185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:31:08Z","timestamp":1765542668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.290.6463.185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1,19]]},"references-count":20,"journal-issue":{"issue":"6463","published-online":{"date-parts":[[1985,1,19]]},"published-print":{"date-parts":[[1985,1,19]]}},"alternative-id":["10.1136\/bmj.290.6463.185"],"URL":"https:\/\/doi.org\/10.1136\/bmj.290.6463.185","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1985,1,19]]}}}