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As well as estimating the overall clinical costs of a screening service it was shown that if the prevalence, including terminations, of open neural tube defects is between 1.25 and five per 1000 births the financial cost of avoiding the birth of a seriously handicapped child who would survive for more than 24 hours is in the range 9000 pounds- 54000 pounds depending on the option adopted and the prevalence of the condition in the target population. Prevalence is the biggest determinant of cost. The data should provide a basis for assessment and discussion of resource priorities in the National Health Service.<\/jats:p>","DOI":"10.1136\/bmj.290.6464.293","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"293-295","source":"Crossref","is-referenced-by-count":19,"title":["Can we afford screening for neural tube defects? The South Wales experience."],"prefix":"10.1136","volume":"290","author":[{"given":"B M","family":"Hibbard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G H","family":"Elder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K T","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,1,26]]},"reference":[{"article-title":"The Working Group on Screening for Neural Tube Defects. 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BrMedJ 1979;i: 1981-3.","journal-title":"BrMedJ"},{"key":"ref_3","first-page":"1315","article-title":"The efficay of a serum screening service for neural tube defects: the South Walesexperience","volume":"i:","author":"Roberts, C.J.; Hibbard, B.M.; Eider, G.H.; et dU","year":"1983","unstructured":"Roberts CJ, Hibbard BM, Eider GH, et dU.The efficay of a serum screening service for neural tube defects: the South Walesexperience. Lac 1983;i:1315-8.","journal-title":"Lac"},{"key":"ref_4","first-page":"1068","article-title":"Dignosdc effectiveness of ultrasoud in detection ofneurai tube defect","volume":"ii:","author":"Roberts, C.J.; Evans, K.T.; Hibbard, B.M.; Laurence, K.M.; Roberts, E.E.; Robertson, I.B.","year":"1983","unstructured":"Roberts CJ, Evans KT, Hibbard BM, Laurence KM, Roberts EE, Robertson IB. Dignosdc effectiveness of ultrasoud in detection ofneurai tube defect. 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London: Royal College of Obsteticiag and Gynacologists, 1984."},{"key":"ref_8","first-page":"40","article-title":"Sacening fot spinabifida cystica. Britshjonal ofPrevensve and Social Medicin","volume":"30","author":"Hagard, S.; Carer, F.; MilDe, R.G.","year":"1976","unstructured":"Hagard S, Carer F, MilDe RG. Sacening fot spinabifida cystica. Britshjonal ofPrevensve and Social Medicin 1976;30:40-53."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/adc.46.246.127","article-title":"Major central nervous system malformations in South Wales. Part IV","volume":"46","year":"1971","unstructured":"Major central nervous system malformations in South Wales. Part IV. Arc DiS Ckild 1971;46: 127-38.","journal-title":"Arc DiS Ckild"},{"key":"ref_10","first-page":"33145","article-title":"Mahoney M1. Ultrasound in the diagnosis of congenital anomalies","volume":"134","author":"HobbinsJC, Frannum P.A.; RL, Berkwity; R, Silverman","year":"1979","unstructured":"HobbinsJC, Frannum PA, Berkwity RL, Silverman R, Mahoney M1. Ultrasound in the diagnosis of congenital anomalies. Ami7 ObstaGynecol 1979;134:33145."},{"key":"ref_11","first-page":"705","article-title":"Diagnostic ulasound: early detection of fetal neural tube defects","volume":"56","author":"Robinson, H.P.; Hood, V.D.; Adam, A.H.; Gibson, A.A.; Smith, M.A.F.","year":"1980","unstructured":"Robinson HP, Hood VD, Adam AH, Gibson AA, Smith MAF. Diagnostic ulasound: early detection of fetal neural tube defects. Obste Gynecol 1980;56:705-10.","journal-title":"Obste Gynecol"},{"key":"ref_12","first-page":"351","article-title":"Early prenatal diagnosis of neural tube defects by ultas. Clin Obstet Gynecol","volume":"20","author":"Campbell, S.","year":"1977","unstructured":"Campbell S. Early prenatal diagnosis of neural tube defects by ultas. Clin Obstet Gynecol 1977;20:351-9."},{"key":"ref_13","first-page":"2","article-title":"An asessment of the hazards of amniocentesis","volume":"85","author":"Party, Medical Research Council Working","year":"1978","unstructured":"Medical Research Council Working Party. An asessment of the hazards of amniocentesis. 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