{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:18:41Z","timestamp":1789730321332,"version":"4.0.1"},"reference-count":7,"publisher":"BMJ","issue":"6470","license":[{"start":{"date-parts":[[1985,3,9]],"date-time":"1985-03-09T00:00:00Z","timestamp":479174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,3,9]]},"abstract":"<jats:p>Several episodes of acute hepatic enlargement associated with a dramatic fall in haemoglobin concentration were observed in two patients with sickle cell anaemia. No appreciable disturbances of liver function or signs of cardiac failure were evident. The most likely mechanism was sequestration of sickled erythrocytes in the liver. This complication, which may have a basis similar to that of splenic sequestration and the sickle lung syndrome, may be easily overlooked unless the size of the liver is regularly monitored in patients with sickle cell crisis.<\/jats:p>","DOI":"10.1136\/bmj.290.6470.744","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"744-745","source":"Crossref","is-referenced-by-count":58,"title":["Hepatic sequestration in sickle cell anaemia."],"prefix":"10.1136","volume":"290","author":[{"given":"C S","family":"Hatton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bunch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0140-6736(81)92739-2","article-title":"Outbreak of aplastic crises in sickle cell anaemia associated with parvovirus-like agent","volume":"ii:","author":"Serjeant, G.R.; Topley, J.M.; Mason, K.","year":"1981","unstructured":"Serjeant GR, Topley JM, Mason K, et al. Outbreak of aplastic crises in sickle cell anaemia associated with parvovirus-like agent. Lancet 1981;ii:595-7.","journal-title":"Lancet"},{"key":"ref_2","first-page":"1515","article-title":"Early deaths in Jamaican children with sickle cell disease","volume":"i:","author":"Rogers, D.W.; Clarke, J.M.; Cupidore, L.; Ramlal, A.M.; Sparke, B.R.; Serjeant, G.R.","year":"1978","unstructured":"Rogers DW, Clarke JM, Cupidore L, Ramlal AM, Sparke BR, Serjeant GR. Early deaths in Jamaican children with sickle cell disease. Br Med J 1978;i:1515-6.","journal-title":"Br Med J"},{"key":"ref_3","first-page":"36","article-title":"Acute chest syndrome in sickle cell disease","volume":"i:","author":"Davies, S.C.; Luie, P.J.; Win, A.A.; Riordan, J.F.; Brozovic, M.","year":"1984","unstructured":"Davies SC, Luie PJ, Win AA, Riordan JF, Brozovic M. Acute chest syndrome in sickle cell disease. Lancet 1984;i:36-8.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0002-9343(50)90291-9","article-title":"Sickle cell anaemia. Clinical study of 54 cases","volume":"9","author":"Henderson, A.B.","year":"1950","unstructured":"Henderson AB. Sickle cell anaemia. Clinical study of 54 cases. Am j Med 1950;9: 757.","journal-title":"Am j Med"},{"key":"ref_5","first-page":"99","article-title":"The liver in sickle cell anemia","volume":"92","author":"Green, T.W.; Conley, C.L.; Berthrong, M.","year":"1953","unstructured":"Green TW, Conley CL, Berthrong M. The liver in sickle cell anemia. Bulletin of the Johns Hopkins Hospital 1953;92:99-127.","journal-title":"Bulletin of the Johns Hopkins Hospital"},{"key":"ref_6","first-page":"533","article-title":"Sickle cell hepatopathy","volume":"70","author":"Sheeley, T.W.","year":"1977","unstructured":"Sheeley TW. Sickle cell hepatopathy. South MedJ7 1977;70:533-8."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0002-9343(80)80008-8","article-title":"The liver in sickle cell disease","volume":"69","author":"Bauer, W.T.; Moore, G.W.; Hutchins, G.M.","year":"1980","unstructured":"Bauer WT, Moore GW, Hutchins GM. The liver in sickle cell disease. Am J Med 1980;69:833-7. (Accepted 8january 1985)","journal-title":"Am J Med"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.290.6470.744","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.290.6470.744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:27:10Z","timestamp":1765549630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.290.6470.744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3,9]]},"references-count":7,"journal-issue":{"issue":"6470","published-online":{"date-parts":[[1985,3,9]]},"published-print":{"date-parts":[[1985,3,9]]}},"alternative-id":["10.1136\/bmj.290.6470.744"],"URL":"https:\/\/doi.org\/10.1136\/bmj.290.6470.744","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3,9]]}}}