{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:36:17Z","timestamp":1792712177223,"version":"4.5.0"},"reference-count":14,"publisher":"BMJ","issue":"6475","license":[{"start":{"date-parts":[[1985,4,13]],"date-time":"1985-04-13T00:00:00Z","timestamp":482198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,4,13]]},"abstract":"<jats:p>A simple test of in vitro thyroxine binding to serum proteins was used to screen serum samples from euthyroid patients with unexplained increases in the free thyroxine index. A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relatives. Increased binding of thyroxine to thyroxine binding prealbumin was diagnosed in one woman with four unaffected relatives. Seven patients with familial dysalbuminaemic hyperthyroxinaemia had been treated for presumed thyrotoxicosis: two had typical Graves' disease and one subacute thyroiditis. Four other patients had been mistakenly treated with radioactive iodine or antithyroid drugs. In previously treated patients familial dysalbuminaemic hyperthyroxinaemia was suspected from the combination of a high serum thyroid stimulating hormone concentration and a normal but invalid free thyroxine index. Physicians should be cautious in accepting a diagnosis of thyrotoxicosis based mainly on a raised serum thyroxine concentration.<\/jats:p>","DOI":"10.1136\/bmj.290.6475.1099","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1099-1102","source":"Crossref","is-referenced-by-count":22,"title":["Detection of familial dysalbuminaemic hyperthyroxinaemia."],"prefix":"10.1136","volume":"290","author":[{"given":"M S","family":"Croxson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B N","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Holdaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Frengley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0140-6736(79)91080-8","article-title":"Raised total thyroxine and free thyroxine index but normal free thyroxine","volume":"i:","author":"Henneman, G.; Docter, R.; Krenner, E.P.","year":"1979","unstructured":"Henneman G, Docter R, Krenner EP, et al. Raised total thyroxine and free thyroxine index but normal free thyroxine. Lancet 1979;i:639-42.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/jcem-53-2-353","article-title":"Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin","volume":"53","author":"Stockigt, JR, Topliss; DJ, Barlow; JW, White; EL, Hurley; DM, Taft; P.","year":"1981","unstructured":"Stockigt JR, Topliss DJ, Barlow JW, White EL, Hurley DM, Taft P. Familial euthyroid thyroxine excess: an appropriate response to abnormal thyroxine binding associated with albumin. J Clin Endocrinol Metab 1981;53:353-9.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM198203183061103","article-title":"Familial dysalbuminemic hyperthyroxinemia","volume":"306","author":"Ruiz, M.; Rajatanavin, R.; Young, R.A.","year":"1982","unstructured":"Ruiz M, Rajatanavin R, Young RA, et al. Familial dysalbuminemic hyperthyroxinemia. N EnglJ7 Med 1982;306:635-9.","journal-title":"N EnglJ7 Med"},{"key":"ref_4","first-page":"513","article-title":"A T,-loaded resin uptake system to detect familial euthyroid thyroxine excess","author":"White, E.L.; Barlow, J.W.; Burke, C.W.; Funder, J.W.; Stockigt, JR","year":"1980","unstructured":"White EL, Barlow JW, Burke CW, Funder JW, Stockigt JR. A T,-loaded resin uptake system to detect familial euthyroid thyroxine excess. In: Stockigt JR, Nagataki S, eds. Thyroid research VIII. 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Clin Endocrinol (Oxf) (in press)."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1056\/NEJM198209233071320","article-title":"Differences between familial hyperthyroxinemic syndromes","volume":"307","author":"Stockigt, JR, White; EC, Barlow; J.W.","year":"1982","unstructured":"Stockigt JR, White EC, Barlow JW. Differences between familial hyperthyroxinemic syndromes. N EnglJ7 Med 1982;307:824-5.","journal-title":"N EnglJ7 Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1056\/NEJM198204223061605","article-title":"Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding pre-albumin","volume":"306","author":"Moses, A.L.; Lawlor, J.; Haddow, J.; Jackson, I.M.D.","year":"1982","unstructured":"Moses AL, Lawlor J, Haddow J, Jackson IMD. Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding pre-albumin. N EnglJ7 Med 1982;306:966-9.","journal-title":"N EnglJ7 Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.7326\/0003-4819-98-3-366","article-title":"Euthyroid hyperthyroxinaemia","volume":"98","author":"Borst, G.C.; Eil, C.; Burman, K.D.","year":"1983","unstructured":"Borst GC, Eil C, Burman KD. Euthyroid hyperthyroxinaemia. Ann Intern Med 1983;98:366-78.","journal-title":"Ann Intern Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1210\/jcem-55-2-244","article-title":"Familial euthyroid thyroxine excess: characterisation of abnormal intermediate affinity thyroxine binding to albumin","volume":"55","author":"Barlow, J.W.; Csicsmann, J.M.; White, E.L.; Funder, J.; Stockigt, JR","year":"1982","unstructured":"Barlow JW, Csicsmann JM, White EL, Funder J, Stockigt JR. Familial euthyroid thyroxine excess: characterisation of abnormal intermediate affinity thyroxine binding to albumin. J Clin Endocrinol Metab 1982;55:244-50.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2265.1981.tb00670.x","article-title":"Limitations of a new free thyroxine assay","volume":"15","author":"Stockigt, JR, De Garis; M, Csicsmann; J, Barlow; JW, White; EL, Hurley; D.M.","year":"1981","unstructured":"Stockigt JR, De Garis M, Csicsmann J, Barlow JW, White EL, Hurley DM. Limitations of a new free thyroxine assay. Clin Endocrinol (Oxf) 1981;15:313-8.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref_12","first-page":"590","article-title":"Prealbumin in the islets of Langerhans","volume":"7","author":"Jacobsson, B.; Petersson, T.; Sandstedt, B.; Carlstrom, A.","year":"1979","unstructured":"Jacobsson B, Petersson T, Sandstedt B, Carlstrom A. Prealbumin in the islets of Langerhans. 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