{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:07:49Z","timestamp":1765476469797,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"6491","license":[{"start":{"date-parts":[[1985,8,3]],"date-time":"1985-08-03T00:00:00Z","timestamp":491875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,8,3]]},"abstract":"<jats:p>Marmosets inoculated intracerebrally with brain tissue from a woman with Gerstmann-Straussler syndrome (an autosomal dominant dementia associated with spongiform change and amyloid deposition) developed an encephalopathy indistinguishable from that seen in marmosets inoculated with brain tissue from a typical case of Creutzfeldt-Jakob disease. As in Huntington's disease, in the pedigree of the patient with Gerstmann-Straussler syndrome women who subsequently developed the illness had increased fecundity. The pathogen in human transmissible dementia may arise from a sequence (which itself sometimes confers a selective advantage) located within the human genome.<\/jats:p>","DOI":"10.1136\/bmj.291.6491.299","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"299-302","source":"Crossref","is-referenced-by-count":56,"title":["Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome?"],"prefix":"10.1136","volume":"291","author":[{"given":"H F","family":"Baker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Ridley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Crow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ana.410050212","article-title":"Creutzfeldt-Jakob disease: patterns of worldwide occurrenc e and the significance of familial and sporadic clustering","volume":"5","author":"Masters, C.L.; Harris, J.O.; Gajdusek, D.C.; CJ, Jr, Gibbs; Bernoulli, C.; Asher, D.M.","year":"1979","unstructured":"Masters CL, Harris JO, Gajdusek DC, Gibbs CJ Jr, Bernoulli C, Asher DM. 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