{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:47:35Z","timestamp":1791193655517,"version":"4.1.0"},"reference-count":27,"publisher":"BMJ","issue":"6500","license":[{"start":{"date-parts":[[1985,10,5]],"date-time":"1985-10-05T00:00:00Z","timestamp":497318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,10,5]]},"abstract":"<jats:p>Forty nine eczematous infants who were still solely and exclusively breast fed and who had never received anything but breast milk were studied for evidence of sensitisation to foods. Thirty four similar infants without eczema formed a control group. The eczematous infants were divided into three groups according to clinical criteria: (1) definite atopic eczema; (2) possible atopic eczema; (3) atopic eczema unlikely. Twenty three infants showed cutaneous hypersensitivity to foods, usually egg and cows' milk. Seven of 14 infants in group 1 and nine of 20 in group 2 were sensitised compared with four of 15 in group 3 and three of 34 controls (p less than 0.01). Ovalbumin was detected in breast milk from 14 of 19 mothers tested after ingestion of egg, the concentrations being the same for mothers feeding eczematous and normal infants. Breast fed babies developing eczema may be sensitised by foods eaten by their mothers.<\/jats:p>","DOI":"10.1136\/bmj.291.6500.932","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"932-935","source":"Crossref","is-referenced-by-count":123,"title":["Egg and cows' milk hypersensitivity in exclusively breast fed infants with eczema, and detection of egg protein in breast milk."],"prefix":"10.1136","volume":"291","author":[{"given":"A","family":"Cant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Kilshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,10,5]]},"reference":[{"key":"ref_1","first-page":"72","article-title":"Immunoglobulin E and the eczema asthma syndrome in early childhood","volume":"i:","author":"Gordon, R.R.; Ward, A.M.; Noble, D.; Allen, R.","year":"1982","unstructured":"Gordon RR, Ward AM, Noble D, Allen R. Immunoglobulin E and the eczema asthma syndrome in early childhood. Lancer 1982;i:72-4.","journal-title":"Lancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/adc.56.3.172","article-title":"Clinical manifestations of allergy related to breast and cow's milk feeding","volume":"56","author":"Hide, D.W.; Guyer, B.M.","year":"1981","unstructured":"Hide DW, Guyer BM. Clinical manifestations of allergy related to breast and cow's milk feeding. Arch Dis Child 1981;56:172-5.","journal-title":"Arch Dis Child"},{"key":"ref_3","first-page":"775","article-title":"JOURNAL VOLUME 291 5 OCTOBER 1985 3 Atherton DW. Breast feeding and atopic eczema","volume":"7","author":"MEDICAL, B.R.I.T.I.S.H.","year":"1983","unstructured":"BRITISH MEDICAL JOURNAL VOLUME 291 5 OCTOBER 1985 3 Atherton DW. Breast feeding and atopic eczema. Br Med 7 1983;287:775-6.","journal-title":"Br Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/adc.58.7.561","article-title":"Does infant feeding affect the risk of allergy?","volume":"58","author":"Burr, M.L.","year":"1983","unstructured":"Burr ML. Does infant feeding affect the risk of allergy? Arch Dis Child 1983; 58:561-5.","journal-title":"Arch Dis Child"},{"key":"ref_5","first-page":"69","article-title":"Allergy in breast fed babies to ingredients in breast milk","volume":"42","author":"Gerrard, J.W.","year":"1979","unstructured":"Gerrard JW. Allergy in breast fed babies to ingredients in breast milk. Ann Allergy 1979;42:69-72.","journal-title":"Ann Allergy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2222.1980.tb02090.x","article-title":"Food allergy in fully breast fed infants","volume":"10","author":"Warner, J.D.","year":"1980","unstructured":"Warner JD. Food allergy in fully breast fed infants. 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BrJ Dermatol 1983;108:633-8.","journal-title":"BrJ Dermatol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0022-3476(81)80757-3","article-title":"Does breast feeding and delayed introduction of solid foods protect against subsequent atopic eczema?","volume":"98","author":"Kramer, M.S.; Moroz, B.","year":"1981","unstructured":"Kramer MS, Moroz B. Does breast feeding and delayed introduction of solid foods protect against subsequent atopic eczema? J Pediatr 1981;98:546-50.","journal-title":"J Pediatr"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/jech.37.2.95","article-title":"Breast feeding, eczema, asthma and hayfever","volume":"37","author":"Taylor, B.; Wadsworth, J.; Golding, J.; Butler, N.","year":"1983","unstructured":"Taylor B, Wadsworth J, Golding J, Butler N. Breast feeding, eczema, asthma and hayfever. J Epidemiol Community Health 1983;37:95-9.","journal-title":"J Epidemiol Community Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2222.1984.tb02243.x","article-title":"Clinical symptoms and IgE responses to common food proteins in atopic healthy children","volume":"14","author":"Hattevig, G.; Kjellman, B.; Johansson, S.G.O.; Bjorksten, B.","year":"1984","unstructured":"Hattevig G, Kjellman B, Johansson SGO, Bjorksten B. Clinical symptoms and IgE responses to common food proteins in atopic healthy children. Clin Allergy 1984;14:551-9.","journal-title":"Clin Allergy"},{"key":"ref_14","first-page":"401","article-title":"A double-blind crossover trial of antigen avoidance diet in atopic eczema","volume":"i:","author":"Atherton, D.J.; Sewell, M.; Soothill, J.F.; Wells, R.S.; Chilvers, C.E.D.","year":"1978","unstructured":"Atherton DJ, Sewell M, Soothill JF, Wells RS, Chilvers CED. A double-blind crossover trial of antigen avoidance diet in atopic eczema. Lancet 1978;i:401-3.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1136\/adc.55.8.608","article-title":"Egg and cow's milk allergy in children","volume":"55","author":"Ford, R.P.K.; Fergusson, D.M.","year":"1980","unstructured":"Ford RPK, Fergusson DM. Egg and cow's milk allergy in children. Arch Dis Child 1980;55:608-10.","journal-title":"Arch Dis Child"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2133.1983.tb01075.x","article-title":"Early diagnosis of infantile seborrhoeic dermatitis and atopic dermatitis. Total and specific IgE levels","volume":"108","author":"Yates, V.M.; Kerr, R.E.I.; Frier, K.; Cobb, S.J.; Mackie, R.M.","year":"1983","unstructured":"Yates VM, Kerr REI, Frier K, Cobb SJ, Mackie RM. Early diagnosis of infantile seborrhoeic dermatitis and atopic dermatitis. Total and specific IgE levels. 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Annales Nestle 1984;42\/3:54-8.","journal-title":"Annales Nestle"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2222.1980.tb02088.x","article-title":"Assessing the value of skin prick tests","volume":"10","author":"Lessof, M.H.; Buisseret, P.D.; Merret, J.; Merret, T.G.; Wraith, D.G.","year":"1980","unstructured":"Lessof MH, Buisseret PD, Merret J, Merret TG, Wraith DG. Assessing the value of skin prick tests. Clin Allergy 1980;10:115-20.","journal-title":"Clin Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0091-6749(80)90234-1","article-title":"Comparison of cord blood immunoglobulin E concentration and maternal allergy for the prediction of atopic diseases in infancy","volume":"65","author":"Michel, F.B.; Bousquet, J.; Geillier, P.; Robinet-Levy, M.; Coulomb, Y.","year":"1980","unstructured":"Michel FB, Bousquet J, Geillier P, Robinet-Levy M, Coulomb Y. Comparison of cord blood immunoglobulin E concentration and maternal allergy for the prediction of atopic diseases in infancy. J Allergy Clin Immunol 1980;65:422-30.","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"ref_22","article-title":"Development of the secretory immune defense (S-IgA and IgM) in newborns and infancy","volume":"30","author":"Mellander, L.; Carlsson, B.; Hanson, L.A.","year":"1983","unstructured":"Mellander L, Carlsson B, Hanson LA. Development of the secretory immune defense (S-IgA and IgM) in newborns and infancy. Lakaresallskapets Riksstamma, Stockholm, 30 Nov-2 Dec, 1983. Abstract PE2.","journal-title":"Lakaresallskapets Riksstamma, Stockholm; Abstract PE2"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2222.1981.tb01602.x","article-title":"Eczema and infant diet","volume":"11","author":"Fergusson, D.M.; Horwood, L.J.; Beautrais, A.L.; Shannon, F.T.; Taylor, B.","year":"1981","unstructured":"Fergusson DM, Horwood LJ, Beautrais AL, Shannon FT, Taylor B. Eczema and infant diet. Clin Allergy 1981;11:325-31.","journal-title":"Clin Allergy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1651-2227.1983.tb09738.x","article-title":"Prophylaxis of atopic disease by six month's total solid food elimination","volume":"72","author":"Kajosaari, M.; Saarinen, U.M.","year":"1983","unstructured":"Kajosaari M, Saarinen UM. Prophylaxis of atopic disease by six month's total solid food elimination. Acta Paediatr Scand 1983;72:411-4.","journal-title":"Acta Paediatr Scand"},{"key":"ref_25","article-title":"Accepted 1 7July 1985)","unstructured":"(Accepted 1 7July 1985)"},{"key":"ref_26","article-title":"555 consecutive men aged under 60 who survived a first attack of unstable angina or myocardial infarction by at least 28 days were admitted into a long term follow up study. Diagnostic criteria for entry to the study have been previously published.' This report concentrates on the 408 (73-4%) of those patients who were smoking one or more cigarettes daily in the three months before their attack","volume-title":"had a diagnosis of unstable angina","author":"Between","year":"1965","unstructured":"Between 1 January 1965 and 31 December 1975, 555 consecutive men aged under 60 who survived a first attack of unstable angina or myocardial infarction by at least 28 days were admitted into a long term follow up study. Diagnostic criteria for entry to the study have been previously published.' This report concentrates on the 408 (73-4%) of those patients who were smoking one or more cigarettes daily in the three months before their attack. Of these, 81 (19-9%) had a diagnosis of unstable angina."},{"key":"ref_27","article-title":"A uniform programme of rehabilitation and secondary prevention included advice in hospital and at follow up against smoking. Routine drugs such as anticoagulants or f blockers were not used. Follow up data were recorded annually at a special clinic, and 384 of the 408 patients who smoked before the study began were alive at their first (\"one year\") examination (mean time to examination was 13-8 months). Subsequent long term follow up of these 384 patients was almost complete when this report was written","volume-title":"had their last follow up examination in","volume":"3","year":"1982","unstructured":"A uniform programme of rehabilitation and secondary prevention included advice in hospital and at follow up against smoking. Routine drugs such as anticoagulants or f blockers were not used. Follow up data were recorded annually at a special clinic, and 384 of the 408 patients who smoked before the study began were alive at their first (\"one year\") examination (mean time to examination was 13-8 months). Subsequent long term follow up of these 384 patients was almost complete when this report was written. By the end of 1983, 188 had died and all but nine (2 3%) had their last follow up examination in 1982 or 1983. The mean duration of follow up to death or last examination was 8 3 years (range 0-1-17 7), with an average of 8-1 annual examinations."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.291.6500.932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.291.6500.932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:45:38Z","timestamp":1765478738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.291.6500.932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10,5]]},"references-count":27,"journal-issue":{"issue":"6500","published-online":{"date-parts":[[1985,10,5]]},"published-print":{"date-parts":[[1985,10,5]]}},"alternative-id":["10.1136\/bmj.291.6500.932"],"URL":"https:\/\/doi.org\/10.1136\/bmj.291.6500.932","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,10,5]]}}}