{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:58:03Z","timestamp":1771876683552,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"6504","license":[{"start":{"date-parts":[[1985,11,2]],"date-time":"1985-11-02T00:00:00Z","timestamp":499737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,11,2]]},"abstract":"<jats:p>The distribution of radioactivity after the oral administration of sucralfate labelled with technetium-99m was studied in 33 patients with Crohn's disease (13 adults, 20 children), 10 with ulcerative colitis (four adults), and 29 controls (23 with upper intestinal disease, four irritable bowel, one hypolactasia, and one malrotation of the gut). Positive scans were obtained in all patients with ulcerative colitis and 29 of 31 with active Crohn's disease. The scans of two patients with inactive Crohn's disease were negative. There were two false negative scans in patients with Crohn's colitis and one false positive scan. Overall, sensitivity was 95% and specificity 97%. Comparison with radiology in 39 patients showed similar distribution of disease in 24 and more extensive disease in 12. The scan was inexpensive, simple to perform, well tolerated, allowed small and large bowel to be visualised simultaneously, and used a lower dose of radiation than barium studies. It may prove useful as a screening test for inflammatory bowel disease and in the serial assessment of disease activity.<\/jats:p>","DOI":"10.1136\/bmj.291.6504.1227","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1227-1230","source":"Crossref","is-referenced-by-count":31,"title":["Detection of inflammatory bowel disease in adults and children: evaluation of a new isotopic technique."],"prefix":"10.1136","volume":"291","author":[{"given":"D J","family":"Dawson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A N","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Shreeve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,2]]},"reference":[{"key":"ref_1","first-page":"101","article-title":"Chronic inflammatory bowel disease in childhood","volume":"284","author":"Chong, S.K.F.; Bartram, C.; Campbell, C.A.; Williams, C.B.; Blackshaw, A.J.; Walker-Smith, J.A.","year":"1982","unstructured":"Chong SKF, Bartram C, Campbell CA, Williams CB, Blackshaw AJ, Walker-Smith JA. 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Colonoscopic diagnosis of minimal change colitis in patients with a normal sigmoidoscopy and normal air contrast barium enema. Lancet 1982;i:650-1.","journal-title":"Lancet"},{"key":"ref_21","article-title":"Bgyond normality","author":"Galen, R.S.; Gambino, SR","year":"1975","unstructured":"Galen RS, Gambino SR. Bgyond normality. New York: Wiley, 1975."},{"key":"ref_22","first-page":"22","article-title":"Theinfluenceofglycocholicacidand sucralfateon transmuralpotential differenceof the human stomach","volume-title":"ulcer, gastric uker, sucralfate, a netv therapeutic concept","author":"Caspary, W.F.","year":"1981","unstructured":"Caspary WF. Theinfluenceofglycocholicacidand sucralfateon transmuralpotential differenceof the human stomach. In: Caspary WF, ed. Duodenal ulcer, gastric uker, sucralfate, a netv therapeutic concept. 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Assessment of disease activity in inflammatory bowel disease: a new approach using 111-In granulocyte scanning. Br Med J 1983;287:1751-3.","journal-title":"Br Med J"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1136\/gut.25.12.1372","article-title":"Evaluation of indium scintigraphy in patients with active inflammtory bowel disease","volume":"25","author":"Buxton-Thomas, M.S.; Dickinson, R.J.; Maltby, P.; Hunter, J.O.; Wraight, E.P.","year":"1984","unstructured":"Buxton-Thomas MS, Dickinson RJ, Maltby P, Hunter JO, Wraight EP. Evaluation of indium scintigraphy in patients with active inflammtory bowel disease. 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