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All were given infusions of whole plasma or albumin solution, or both, to restore their plasma albumin concentrations to normal, which led to a dramatic increase in plasma sodium concentrations and serum osmolality, with a concomitant fall in urinary osmolality in all patients. Neurological features were reversed in four patients. It is suggested that severe hypoalbuminaemia is an important cause of appreciable hyponatraemia; infusions of plasma and albumin in such patients may reverse the biochemical and clinical features and should form the basis of management.<\/jats:p>","DOI":"10.1136\/bmj.291.6504.1253","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1253-1255","source":"Crossref","is-referenced-by-count":14,"title":["Hypoalbuminaemic hyponatraemia: a new syndrome?"],"prefix":"10.1136","volume":"291","author":[{"given":"P","family":"Dandona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0140-6736(81)90261-0","article-title":"Hyponatraemia: mechanisms and management","volume":"ii:","author":"Flear, C.T.; Gill, G.V.","year":"1981","unstructured":"Flear CT, Gill GV. 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