{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:05Z","timestamp":1787016965770,"version":"build-2736575974"},"reference-count":19,"publisher":"BMJ","issue":"6506","license":[{"start":{"date-parts":[[1985,11,16]],"date-time":"1985-11-16T00:00:00Z","timestamp":500947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,11,16]]},"abstract":"<jats:p>Olsalazine (azodisalicylate) is a new drug in which two molecules of 5-aminosalicylic acid are linked by an azo bond. Its role in the treatment of mildly active, distal ulcerative colitis was investigated. Sixty patients were randomly allocated to receive olsalazine 1 g or a placebo as a retention enema nightly for two weeks. Clinical improvement was seen in 19 (66%) and sigmoidoscopic improvement in 17 (59%) of the 29 patients receiving olsalazine compared with 12 (43%) and 11 (39%), respectively, of the 28 in the control group. These differences were not significant. In a second trial 40 patients were randomised to receive oral olsalazine 2 g daily or a placebo capsule for two weeks. Significant clinical and sigmoidoscopic improvement was seen in the patients receiving oral olsalazine compared with the patients receiving placebo capsules. Oral olsalazine may be valuable in the treatment of mildly active ulcerative colitis. Its role in maintaining remission is yet to be determined.<\/jats:p>","DOI":"10.1136\/bmj.291.6506.1373","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1373-1375","source":"Crossref","is-referenced-by-count":100,"title":["Olsalazine in active ulcerative colitis."],"prefix":"10.1136","volume":"291","author":[{"given":"W S","family":"Selby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G D","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ireland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/gut.14.12.923","article-title":"I Dissanavake AS, Truelove SC. 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Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis. Gut 1982;23:1081-7.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/S0016-5085(84)80164-X","article-title":"Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis","volume":"86","author":"Lauritsen, K.; Hansen, J.; Ryde, M.; Rask-Madsen, J.","year":"1984","unstructured":"Lauritsen K, Hansen J, Ryde M, Rask-Madsen J. Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterologv 1984;86: 1496-500.","journal-title":"Gastroenterologv"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/S0140-6736(81)90616-4","article-title":"Disodium azodisalicylate in ulcerative colitis","volume":"ii:","author":"Jewell, D.P.; Truelove, S.C.","year":"1981","unstructured":"Jewell DP, Truelove SC. Disodium azodisalicylate in ulcerative colitis. Lancet 1981;ii: 1168-9.","journal-title":"Lancet"},{"key":"ref_11","first-page":"1041","article-title":"Cortisone in ulcerative colitis","volume":"ii:","author":"Truelove, S.C.; Witts, L.J.","year":"1955","unstructured":"Truelove SC, Witts LJ. Cortisone in ulcerative colitis. BrMedj 1955;ii: 1041-8.","journal-title":"BrMedj"},{"key":"ref_12","first-page":"437","article-title":"Controlled trial of sulphasalazine in the treatment of ulcerative colitis","volume":"5","author":"Dick, A.P.; Grayson, M.J.; Carpenter, R.G.; Petrie, A.","year":"1984","unstructured":"Dick AP, Grayson MJ, Carpenter RG, Petrie A. Controlled trial of sulphasalazine in the treatment of ulcerative colitis. Gut 1984;5:437-42.","journal-title":"Gut"},{"key":"ref_13","first-page":"1315","article-title":"Biopsy studies in ulcerative colitis","volume":"i:","author":"Truelove, S.C.; Richards, W.C.D.","year":"1956","unstructured":"Truelove SC, Richards WCD. Biopsy studies in ulcerative colitis. 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