{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:34:53Z","timestamp":1765481693083,"version":"3.48.0"},"reference-count":23,"publisher":"BMJ","issue":"6508","license":[{"start":{"date-parts":[[1985,11,30]],"date-time":"1985-11-30T00:00:00Z","timestamp":502156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,11,30]]},"abstract":"<jats:p>Results are reported in 35 patients with prolactinomas who underwent pituitary surgery within the past five years. After surgery prolactin concentrations became normal in 26 patients and symptoms were alleviated, and nine normal pregnancies were achieved in seven women, including all those who had complained of infertility. Normal prolactin concentrations were restored in 16 of 17 patients with tumours 5-19 mm in diameter but in only six of 11 with tumours less than or equal to 4 mm and four of seven with tumours greater than or equal to 20 mm. Normal prolactin concentrations were restored in all those with preoperative concentrations below 1000 mU\/l but in none of those with concentrations above 10 000 mU\/l. Although not all of the patients were followed up for five years, hyperprolactinaemia did not recur in any patient whose prolactin concentration had returned to normal six weeks after surgery. This included 16 patients with macroprolactinomas (greater than 10 mm in diameter), who were followed up for from two to five years. These data contrast strikingly with those reported by others at similar stages of follow up and show clearly that partial hypophysectomy offers an acceptable alternative treatment for selected patients with prolactinomas.<\/jats:p>","DOI":"10.1136\/bmj.291.6508.1547","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1547-1550","source":"Crossref","is-referenced-by-count":30,"title":["Management of selected patients with hyperprolactinaemia by partial hypophysectomy."],"prefix":"10.1136","volume":"291","author":[{"given":"M F","family":"Scanlon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E D","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hourihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/neurosurgery\/16.CN_suppl_1.185","article-title":"Transsphenoidal microsurgery of the normal and pathological pituitary","volume":"16","author":"J, I.Hardy","year":"1969","unstructured":"I Hardy J. Transsphenoidal microsurgery of the normal and pathological pituitary. Clin Neurosurg 1969;16: 185-217.","journal-title":"Clin Neurosurg"},{"key":"ref_2","first-page":"1","article-title":"Le prolactinome","volume":"27","author":"Hardy, J.","year":"1981","unstructured":"Hardy J. Le prolactinome. Neurochirurgie 1981;27:1-110.","journal-title":"Neurochirurgie"},{"key":"ref_3","first-page":"27","article-title":"Selective removal of hypersecreting pituitary adenomas; an analysis of endocrine function, operative and microsurgical findings in 101 cases","volume":"35","author":"Ludecke, D.; Kantzky, R.; Saeger, W.","year":"1976","unstructured":"Ludecke D, Kantzky R, Saeger W. Selective removal of hypersecreting pituitary adenomas; an analysis of endocrine function, operative and microsurgical findings in 101 cases. ActaNeurochir 1976;35:27-42.","journal-title":"ActaNeurochir"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1227\/00006123-197809000-00002","article-title":"Anterior pituitary function before and after transsphenoidal microsurgical resection of pituitary tumours","volume":"3","author":"McLanahan, C.S.; Christy, J.H.; Tindall, G.T.","year":"1979","unstructured":"McLanahan CS, Christy JH, Tindall GT. Anterior pituitary function before and after transsphenoidal microsurgical resection of pituitary tumours. Neurosurgeryv 1979;3:142-5.","journal-title":"Neurosurgeryv"},{"key":"ref_5","first-page":"273","article-title":"Surgical failures in prolactinomas","volume-title":"adenomas: biology, physiopathologv and treatment. 2nd European wuorkshop","author":"Fahlbusch, R.","year":"1980","unstructured":"Fahlbusch R. Surgical failures in prolactinomas. In: Deroma PJ, Jedynax CP, Peillon F, eds. Pituitary adenomas: biology, physiopathologv and treatment. 2nd European wuorkshop. Paris: Axlepios, 1980:273-82."},{"key":"ref_6","first-page":"8","article-title":"Persistent defect in regulation of prolactin secretion following successful pituitary tumour removal in women with galactorrhoeaamenorrhoea syndrome","volume":"51","author":"HStG, Tucker; HV, Lanaford; DF, Gardner; WG, Blackard","year":"1980","unstructured":"Tucker HStG, Lanaford HV, Gardner DF, Blackard WG. Persistent defect in regulation of prolactin secretion following successful pituitary tumour removal in women with galactorrhoeaamenorrhoea syndrome. ] Clin Endocrinol Metab 1980;51::%8-71.","journal-title":"Clin Endocrinol Metab"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0015-0282(16)45552-4","article-title":"Surgical treatment of pituitary prolactinomas: post-operative prolactin and fertility in 70 patients","volume":"35","author":"Llandolt, A.M.","year":"1981","unstructured":"Llandolt AM. Surgical treatment of pituitary prolactinomas: post-operative prolactin and fertility in 70 patients. Fertil Steril 1981;35:620-5.","journal-title":"Fertil Steril"},{"key":"ref_8","first-page":"108","article-title":"Transsphenoidal microsurgical treatment of prolactinproducing pituitarv adenomas","volume-title":"Results in 100 patients. Mayo Clin Proc 1983; 58","author":"Randall, R.V.; Laws, E.R.; Abbond, C.F.","unstructured":"Randall RV, Laws ER, Abbond CF, et al. Transsphenoidal microsurgical treatment of prolactinproducing pituitarv adenomas. Results in 100 patients. Mayo Clin Proc 1983;58:108-21."},{"key":"ref_9","first-page":"\"789","article-title":"Surgical management of pituitary adenoma","volume-title":"Clinics in Endocrinology and Metabolism No 12.) 10 Serri","volume":"0","author":"Teasdale, G.","year":"1983","unstructured":"Teasdale G. Surgical management of pituitary adenoma. In: Scanlon MF, ed. Neuroendocrinology. London: Saunders, 1983:789-823. (Clinics in Endocrinology and Metabolism No 12.) 10 Serri 0, Rasio E, Beauregard H, et al. Recurrence of hyperprolactinaemia after selective transsphenoidal adenomectomy in women with prolactinoma. N Engl7 Med 1983;309:280-7."},{"key":"ref_10","first-page":"419","article-title":"Long term treatment of galactorrhoea and hypogonadism with bromocriptine","volume":"ii:","author":"Thorner, M.O.; McNeilly, A.S.; Hagen, C.; Besser, G.M.","year":"1974","unstructured":"Thorner MO, McNeilly AS, Hagen C, Besser GM. Long term treatment of galactorrhoea and hypogonadism with bromocriptine. BrMedJ 1974;ii:419-22.","journal-title":"BrMedJ"},{"key":"ref_11","first-page":"182","volume":"290","author":"Grossman, A.; Prolactinomas, Besser G.M.","year":"1985","unstructured":"Grossman A, Besser GM. Prolactinomas. BrMedJ 1985;290:182-4.","journal-title":"BrMedJ"},{"key":"ref_12","first-page":"1155","article-title":"Tests of prolactin secretion in diagnosis of prolactinomas","volume":"i:","author":"Cowden, E.A.; Thomson, J.A.; Doyle, D.; Ratcliffe, J.G.; MacPherson, P.; Teasdale, G.M.","year":"1979","unstructured":"Cowden EA, Thomson JA, Doyle D, Ratcliffe JG, MacPherson P, Teasdale GM. Tests of prolactin secretion in diagnosis of prolactinomas. Lancet 1979;i: 1155-8.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2265.1981.tb00608.x","article-title":"Altered dopaminergic regulation ol thvrotrophin release in patients with prolactinomas: comparison with other tests of hypothalamic function","volume":"14","author":"Scanlon, M.F.; Rodriguez-Arnao, M.D.; Weightman, D.","year":"1981","unstructured":"Scanlon MF, Rodriguez-Arnao MD, Weightman D, et al. Altered dopaminergic regulation ol thvrotrophin release in patients with prolactinomas: comparison with other tests of hypothalamic function. Clin Endocrinol 1981;14:133-43.","journal-title":"Clin Endocrinol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2265.1983.tb03191.x","article-title":"Reciprocal pattern of the TSH and PRL responses to dopamine receptor blockade in women with physiological or pathological hyperprolactinaemia","volume":"18","author":"Massara, F.; Camanni, F.; Martra, M.; Dolfin, G.C.; Muller, E.E.; Molinatti, G.M.","year":"1983","unstructured":"Massara F, Camanni F, Martra M, Dolfin GC, Muller EE, Molinatti GM. Reciprocal pattern of the TSH and PRL responses to dopamine receptor blockade in women with physiological or pathological hyperprolactinaemia. Clin Endocrznol 1983;18:103-10.","journal-title":"Clin Endocrznol"},{"issue":"25","key":"ref_15","first-page":"5","article-title":"Uber ein Modifikation der schlofferschen Operation von Tumoren der Hypophyse","volume":"1912","author":"0, Chiari","unstructured":"Chiari 0. Uber ein Modifikation der schlofferschen Operation von Tumoren der Hypophyse. Wien Klin Wochenschr 1912;25:5-6.","journal-title":"Wien Klin Wochenschr"},{"key":"ref_16","first-page":"1000","article-title":"Use of monoclonal antihapten antibodies for immunolocalisation of tissue antigens","volume":"34","author":"Jasani, B.; Wynford-Thomas, D.; Williams, E.D.","year":"1984","unstructured":"Jasani B, Wynford-Thomas D, Williams ED. Use of monoclonal antihapten antibodies for immunolocalisation of tissue antigens. J Clin Pathol 1984;34:1000-2.","journal-title":"J Clin Pathol"},{"key":"ref_17","article-title":"Short and long term results of surgical treatment of pituitary adenomas","volume-title":"Trends in the diagnosts and treatment ofpituitarv adenomnas","author":"Charpentier, G.; de Plunkett, T.; Jedymak, C.P.","year":"1983","unstructured":"Charpentier G, de Plunkett T, Jedymak CP, et al. Short and long term results of surgical treatment of pituitary adenomas. In: Lamberts SWJ, Tilders SJ, Van der Veen DEE, Assies J, eds. Trends in the diagnosts and treatment ofpituitarv adenomnas. Amsterdam: Free University Press, 1983."},{"key":"ref_18","first-page":"141","article-title":"Prolactin dynamics and tumour size in the prediction of surgical outcome for prolactinoma","volume":"54","author":"Gordon, D.; Richards, A.; Bulloch, R.","year":"1985","unstructured":"Gordon D, Richards A, Bulloch R, et al. Prolactin dynamics and tumour size in the prediction of surgical outcome for prolactinoma. QJMed 1985;54:141-51.","journal-title":"QJMed"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/jama.1984.03350070039020","article-title":"Long-term follow-up of transsphenoidal selective adenomectomy for prolactinoma","volume":"252","author":"Rodman, E.F.; Molitch, M.E.; Post, K.D.","year":"1984","unstructured":"Rodman EF, Molitch ME, Post KD, et al. Long-term follow-up of transsphenoidal selective adenomectomy for prolactinoma. JAMA 1984;252:921-4.","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1210\/jcem-57-6-1270","article-title":"Defective regulation of prolactin secretion after successful removal of prolactinomas","volume":"57","author":"Camanni, F.; Ghigo, E.; Ciccarelli, E.","year":"1983","unstructured":"Camanni F, Ghigo E, Ciccarelli E, et al. Defective regulation of prolactin secretion after successful removal of prolactinomas. J Clin Endoerinol Metab 1983;57:1270-6.","journal-title":"J Clin Endoerinol Metab"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1530\/acta.0.0940450","article-title":"The clinical and biochemical features in 26 patients with prolactinoma before and after transsphenoidal microresection","volume":"94","author":"Samaan, N.A.; Elha, G.E.; Leavens, M.E.; Franklin, R.R.","year":"1980","unstructured":"Samaan NA, Elha; GE, Leavens ME, Franklin RR. The clinical and biochemical features in 26 patients with prolactinoma before and after transsphenoidal microresection. Acta Endocrinol 1980;94:450-8.","journal-title":"Acta Endocrinol"},{"author":"Accepted 23,7uly 1985)","key":"ref_22","unstructured":"(Accepted 23,7uly 1985)"},{"key":"ref_23","unstructured":"Seventy seven patients who were presumed to have a prolactinoma on the basis of biochemical findings underwent transsphenoidal operation between October 1977 and September 1983. Sixty one patients were found to have a microadenoma, and hyperprolactinaemia was cured in 46 of these, amenorrhoea in 39 (80% of those with the symptom), galactorrhoea in 32 (80%), and infertility in 31 (82%). Four of eight patients found to have a macroadenoma were also satisfactorily treated with surgery. Two patients had a lesion other than a prolactinoma, and in six a tumour could not be found at operation; four of these last eight patients had a normal serum prolactin concentration after operation. Recurrent hyperprolactinaemia was rare, occurring in only three patients in the series overall; among the 32 patients foliowed up for more than five years only two of the 22 whose operation had initially been successful developed recurrent hyperprolactinaemia.","article-title":"Seventy seven patients who were presumed to have a prolactinoma on the basis of biochemical findings underwent transsphenoidal operation between October 1977 and September 1983. Sixty one patients were found to have a microadenoma, and hyperprolactinaemia was cured in 46 of these, amenorrhoea in 39 (80% of those with the symptom), galactorrhoea in 32 (80%), and infertility in 31 (82%). Four of eight patients found to have a macroadenoma were also satisfactorily treated with surgery. Two patients had a lesion other than a prolactinoma, and in six a tumour could not be found at operation; four of these last eight patients had a normal serum prolactin concentration after operation. Recurrent hyperprolactinaemia was rare, occurring in only three patients in the series overall; among the 32 patients foliowed up for more than five years only two of the 22 whose operation had initially been successful developed recurrent hyperprolactinaemia"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.291.6508.1547","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.291.6508.1547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:31:56Z","timestamp":1765481516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.291.6508.1547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11,30]]},"references-count":23,"journal-issue":{"issue":"6508","published-online":{"date-parts":[[1985,11,30]]},"published-print":{"date-parts":[[1985,11,30]]}},"alternative-id":["10.1136\/bmj.291.6508.1547"],"URL":"https:\/\/doi.org\/10.1136\/bmj.291.6508.1547","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1985,11,30]]}}}