{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:34:53Z","timestamp":1765481693011,"version":"3.48.0"},"reference-count":33,"publisher":"BMJ","issue":"6508","license":[{"start":{"date-parts":[[1985,11,30]],"date-time":"1985-11-30T00:00:00Z","timestamp":502156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1985,11,30]]},"abstract":"<jats:p>Seventy seven patients who were presumed to have a prolactinoma on the basis of biochemical findings underwent transsphenoidal operation between October 1977 and September 1983. Sixty one patients were found to have a microadenoma, and hyperprolactinaemia was cured in 46 of these, amenorrhoea in 39 (80% of those with the symptom), galactorrhoea in 32 (80%), and infertility in 31 (82%). Four of eight patients found to have a macroadenoma were also satisfactorily treated with surgery. Two patients had a lesion other than a prolactinoma, and in six a tumour could not be found at operation; four of these last eight patients had a normal serum prolactin concentration after operation. Recurrent hyperprolactinaemia was rare, occurring in only three patients in the series overall; among the 32 patients followed up for more than five years only two of the 22 whose operation had initially been successful developed recurrent hyperprolactinaemia.<\/jats:p>","DOI":"10.1136\/bmj.291.6508.1550","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1550-1553","source":"Crossref","is-referenced-by-count":27,"title":["Treatment of presumed prolactinoma by transsphenoidal operation: early and late results."],"prefix":"10.1136","volume":"291","author":[{"given":"J A","family":"Thomson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Teasdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"McCruden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,11,30]]},"reference":[{"key":"ref_1","first-page":"1105","article-title":"Treatment of prolactinomas with megavoltage radiotherapy","volume":"7","author":"A, I.Grossman; M, Cohen B.L.Charlesworth; e al","year":"1984","unstructured":"I Grossman A, Cohen BL. Charlesworth M, e al. Treatment of prolactinomas with megavoltage radiotherapy. Br.Ifed 7 1984;288:1105-9.","journal-title":"Br. Ifed"},{"key":"ref_2","first-page":"1538","article-title":"Treatment of prolactinomas with megavoltage radiotherapy","volume":"288","author":"Teasdale, G.; Tlhomson, J.A.; Macpherson, P.","year":"1984","unstructured":"Teasdale G, Tlhomson JA, Macpherson P. Treatment of prolactinomas with megavoltage radiotherapy. BrMe d_ 1984;288:1538-9.","journal-title":"BrMe d_"},{"key":"ref_3","first-page":"113","article-title":"Laboratory assessment of prolactin status. zl nn Clin Btotchem","volume":"16","author":"Cowden, E.A.; Beastall, Ratcliffe W.A.X.; GH, Ratcliffe; J.G.","year":"1979","unstructured":"Cowden EA, Ratcliffe WAX Beastall GH, Ratcliffe JG. Laboratory assessment of prolactin status. zl nn Clin Btotchem 1979; 16: 113-2 1."},{"key":"ref_4","first-page":"568","article-title":"The reliabilitv of radiology in detecting prolactin secreting pituitarv microadenomas","volume":"54","author":"Teasdale, E.; Macpherson, P.; I'easdale, G.","year":"1981","unstructured":"Teasdale E, Macpherson P, I'easdale G. The reliabilitv of radiology in detecting prolactin secreting pituitarv microadenomas. Br]7 Radiol 1981;54:568-71."},{"key":"ref_5","first-page":"1155","article-title":"Tests of prolactin secretion in diagnosis of prolactinomas","volume":"i:","author":"Cowden, E.A.; Ratcliffe, J.G.; Thomson, J.A.; Macpherson, P.; Doyle, D.; Teasdale, G.","year":"1979","unstructured":"Cowden EA, Ratcliffe JG, Thomson JA, Macpherson P, Doyle D, Teasdale G. Tests of prolactin secretion in diagnosis of prolactinomas. Lancet 1979;i: 1155-8.","journal-title":"Lancet"},{"key":"ref_6","first-page":"141","article-title":"IProlactin dynamics and tumour suze in the prediction of surgical outcome for prolactinoma","volume":"54","author":"Gordon, D.; Bullock, Richards A.; R.","year":"1985","unstructured":"Gordon D, Richards A. Bullock R, et al. IProlactin dynamics and tumour suze in the prediction of surgical outcome for prolactinoma. Q Med 1985;54:141-51.","journal-title":"Q Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3171\/jns.1982.57.5.0637","article-title":"U'se of cavernous sinography to detect aneurvsm or anomalies of the infraclinotd carotid artery","volume":"57","author":"easdale G, S.; P, M1acpherson","year":"1982","unstructured":"S 'I'easdale G, M1acpherson P. U'se of cavernous sinography to detect aneurvsm or anomalies of the infraclinotd carotid artery. 7 Neurosurg 1982;57:637-4i.","journal-title":"7 Neurosurg"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1259\/0007-1285-53-631-733","article-title":"Combined metrizamide ventriculogram and cisternogram via sub occipital route","volume":"53","author":"Macpherson, P.","year":"1980","unstructured":"Macpherson P. Combined metrizamide ventriculogram and cisternogram via sub occipital route. Bry Radiol 1980;53:733-4.","journal-title":"Bry Radiol"},{"key":"ref_9","first-page":"789","article-title":"Surgical management of pituitary adenoma","volume":"12","author":"Teasdale, G.","year":"1983","unstructured":"Teasdale G. Surgical management of pituitary adenoma. Clin EndocrintolAfetab 1983;12:789-824.","journal-title":"Clin EndocrintolAfetab"},{"key":"ref_10","first-page":"326","article-title":"'I'R. Combined test for assessment of anterior pituitary function","volume":"i:","author":"Harsoulis, P.; Marshall, J.C.; Kukus, S.F.; Burke, C.W.; London, D.R.; Fraser","year":"1973","unstructured":"Harsoulis P, Marshall JC, Kukus SF, Burke CW, London DR, Fraser 'I'R. Combined test for assessment of anterior pituitary function. BrMedJ 1973;i:326-9.","journal-title":"BrMedJ"},{"key":"ref_11","first-page":"7","article-title":"Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal range","volume":"288","author":"Wathen, N.C.; Perry, L.; Lilford, P.J.; Chard, T.","year":"1984","unstructured":"Wathen NC, Perry L, Lilford PJ, Chard T. Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal range. BrMIfed] 1984;288:7-9.","journal-title":"BrMIfed]"},{"key":"ref_12","first-page":"108","article-title":"Transsphenoidal microsurgical treatment of prolactin producing pituttarv adenoma","volume-title":"May, o Cin Proc 1983; 58","author":"Randall, R.V.; Laws, E.R.; Abboud, C.F.; Ebersold, M.J.; Kao, P.C.; Scheithauer, B.W.","unstructured":"Randall RV, Laws ER, Abboud CF, Ebersold MJ, Kao PC, Scheithauer BW. Transsphenoidal microsurgical treatment of prolactin producing pituttarv adenoma. May,o Cin Proc 1983;58: 108-21."},{"issue":"73","key":"ref_13","first-page":"1","article-title":"Combined medical and surgical treatment of prolactin pituitary tumours. Settninars it Reproductive Endocnrnology","volume":"2","author":"Marcovitz, S.; Hardy, J.","year":"1984","unstructured":"Marcovitz S, Hardy J. Combined medical and surgical treatment of prolactin pituitary tumours. Settninars it Reproductive Endocnrnology 1984;2:73-X 1."},{"key":"ref_14","first-page":"302","article-title":"Galactorrhoea-amenorrhoea syndrome: follosw up of forty-five patients after pituitary tumour removal","volume":"94","author":"l'ucker H, Grubb SR, t'igand JP","year":"1981","unstructured":"'l'ucker H, Grubb SR, t'igand JP, et al. Galactorrhoea-amenorrhoea syndrome: follosw up of forty-five patients after pituitary tumour removal. Ann InterIt fed 1981;94:302-7."},{"key":"ref_15","first-page":"33","article-title":"Transsphenoidal microsurgery for prolactin secreting pituitarv adenomas. Results in 100 women with amenorrhoea-galactorrhoea syndrome._7 N'eurosurg","volume":"56","author":"Faria, M.A.; Tindall, G.T.","year":"1982","unstructured":"Faria MA, Tindall GT. Transsphenoidal microsurgery for prolactin secreting pituitarv adenomas. Results in 100 women with amenorrhoea-galactorrhoea syndrome._7 N'eurosurg 1982;56:33-43."},{"key":"ref_16","first-page":"1","volume":"l:","author":"Leprolactinomie, HardyJ 1981.","year":"1981","unstructured":"HardyJ 1981. Leprolactinomie.Neurochirurgte 1981;27(suppl l:1-110.","journal-title":"Neurochirurgte"},{"key":"ref_17","first-page":"280","article-title":"Recurrence of hyperprolactinaemia after selective transsphenoidal adenomectomv in women with prolactinoma","volume":"309","author":"N Etgl J7 Med","year":"1983","unstructured":"Serri 0, Rasio E, Beauregard H, Hardy J, Somma M. Recurrence of hyperprolactinaemia after selective transsphenoidal adenomectomv in women with prolactinoma. N Etgl J7 Med 1983;309:280-2."},{"key":"ref_18","article-title":"Surgical treatment of prolactinomas. Short aiid lotig term results: prognostic factors","author":"Charpentier, G.; de Plunkett, T.; Jedynak, C.P.; Peillon, F.; Derome, P.","unstructured":"Charpentier G, de Plunkett T, Jedynak CP, Peillon F, Derome P. Surgical treatment of prolactinomas. Short aiid lotig term results: prognostic factors. Horm Res (in press).","journal-title":"Horm Res"},{"key":"ref_19","first-page":"921","article-title":"Post MD 1984 long tcrm follow-up to transsphenoidal adenomectomy for prolactinoma","volume":"252","author":"Biller, B.J.; Reichcin, S.; Rodman, E.F.; Molitch, M.E.","year":"1984","unstructured":"Biller BJ, Reichcin S, Rodman EF, Molitch ME. Post MD 1984 long tcrm follow-up to transsphenoidal adenomectomy for prolactinoma. ]AALAI 1984;252:921-4.","journal-title":"]AALAI"},{"key":"ref_20","first-page":"129","article-title":"Abnormal prolactin secretion in men and women","volume-title":"Endocnnology of human infertility. N'ea aspects","author":"Jacobs, H.S.","year":"1981","unstructured":"Jacobs HS. Abnormal prolactin secretion in men and women. In: Grosignami PG, Rubin BL, eds. Endocnnology of human infertility. N'ea aspects. London: Academic Press, 1981:129-38."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2265.1982.tb03175.x","article-title":"Menstrual function and serum prolactin levels after long-term bromocriptine treatment of hvperprolactinaemic amenorrhoca","volume":"16","author":"Bergh, T.; Millis, S.J.; W'ide, L.","year":"1982","unstructured":"Bergh T, Millis SJ, W'ide L. Menstrual function and serum prolactin levels after long-term bromocriptine treatment of hvperprolactinaemic amenorrhoca. Clit Endocrinol 1982;16: 587-93.","journal-title":"Clit Endocrinol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/bmj.290.6462.117-a","article-title":"Long term suppression of prolactin concentrations after bromccriptine induced regression of pituitary tumours","volume":"290","author":"Hancock, K.W.; Scott, J.S.; Lamb, J.T.; Gibson, R.M.; Chapman, C.","year":"1985","unstructured":"Hancock KW, Scott JS, Lamb JT, Gibson RM, Chapman C. Long term suppression of prolactin concentrations after bromccriptine induced regression of pituitary tumours. Br Mled J 1985;290:117-8.","journal-title":"Br Mled J"},{"key":"ref_23","first-page":"868","article-title":"Hvperprolactinaemia: long term effects of bromocriptine","volume":"75","author":"Johnstone, D.G.; Prescott, R.W.G.; Kendall-Taylor, P.","year":"1983","unstructured":"Johnstone DG, Prescott RWG, Kendall-Taylor P, et al. Hvperprolactinaemia: long term effects of bromocriptine. Am] Sled 1983;75:868-79.","journal-title":"Am] Sled"},{"key":"ref_24","first-page":"473","article-title":"Treatment of prolactin-secreting pituitary tumours in young women by needle implantation of radioactive yttrium","volume":"47","author":"Kelly, W.F.; Mashiter, K.; Doyle, F.H.; Banks, L.M.; Joplin, G.F.","year":"1978","unstructured":"Kelly WF, Mashiter K, Doyle FH, Banks LM, Joplin GF. Treatment of prolactin-secreting pituitary tumours in young women by needle implantation of radioactive yttrium. Q 7 Med 1978;47:473-93."},{"key":"ref_25","first-page":"129","article-title":"Pituitary prolactinomas","volume":"17","author":"Nabarro, J.D.N.","year":"1982","unstructured":"Nabarro JDN. Pituitary prolactinomas. ClinEndocrinol 1982;17:129-55.","journal-title":"ClinEndocrinol"},{"key":"ref_26","first-page":"1101","article-title":"Psychotic reactions during treatment of pituitary tumours with dopamine agonists","volume":"7","author":"Turner, T.H.; Cookson, J.C.; Wass, J.A.H.; Drury, P.L.; Price, P.A.; Besser, G.M.","year":"1984","unstructured":"Turner TH, Cookson JC, Wass JAH, Drury PL, Price PA, Besser GM. Psychotic reactions during treatment of pituitary tumours with dopamine agonists. Br,Iled 7 1984;289:1101-3.","journal-title":"Br, Iled"},{"key":"ref_27","first-page":"187","article-title":"Pituitary apoplexy: its incidence and clinical significance..]INurosurg","volume":"55","author":"Wakai, S.; Teramoto, Fukushima T.; A, Sano; K.","year":"1981","unstructured":"Wakai S, Fukushima T. Teramoto A, Sano K. Pituitary apoplexy: its incidence and clinical significance..]INurosurg 1981;55:187-93."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1210\/jcem-48-6-931","article-title":"Conventional supervoltage irradiation is an effective treatment for acromegaly","volume":"48","author":"P, Eastman R.C.Gordon; J, Roth","year":"1979","unstructured":"Eastman RC. Gordon P, Roth J. Conventional supervoltage irradiation is an effective treatment for acromegaly. J Clin Endo rinol.Ietab 1979;48:931-40.","journal-title":"J Clin Endo rinol. Ietab"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/bmj.285.6348.1078","article-title":"C'I' abnormalities of the pituitary in hyperprolactinaemic womcn with normal or equivocal sellae radiologicallv","volume":"285","author":"Jung, R.T.; W'hite, M.C.; Bowles, N.B.; Bvdder, G.; Mashiter, K.; Joplin, G.F.","year":"1982","unstructured":"Jung RT, W'hite MC, Bowles NB, Bvdder G, Mashiter K, Joplin GF. C'I' abnormalities of the pituitary in hyperprolactinaemic womcn with normal or equivocal sellae radiologicallv. Br Med] 1982;285:1078-81.","journal-title":"Br Med]"},{"key":"ref_30","first-page":"721","article-title":"Prolactin secreting pituitary microadenomas: inaccuracy of high resolution CT scanning., ANR","volume":"5","author":"Davis, P.C.; Hoffrrman, J.C.; Tindall, G.T.; Braun, I.F.","year":"1984","unstructured":"Davis PC, Hoffrrman JC, Tindall GT, Braun IF. Prolactin secreting pituitary microadenomas: inaccuracy of high resolution CT scanning.,ANR 1984;5:721-6."},{"author":"Accepted 297ultv 1985","key":"ref_31","unstructured":"Accepted 297ultv 1985"},{"key":"ref_32","unstructured":"Footprints of crime Exactly 300 years ago, in 1685, two brothers quarrelled over a \"worthless woman\" and fought a duel in Southampton Fields. The spot has since become familiar to visitors to BMA House under the name of Tavistock Square. In their frenzy the brothers trampled the grass until one of them fell mortally wounded in an agonised posture on the ground. The woman meanwhile watched them from a nearby bank. According to legend the depression made in the ground by the dead brother's body and their footmarks in the turf were visible as bare hollows a century later. A letter dated 1778 and published in the Gentleman's Magazine in 1804 recounts the story and tells how the traces remained on the ground despite attempts to obliterate them by ploughing. The writer of that letter had visited the spot and there saw, in addition to the duellists' traces, a hollow where the woman was supposed to have sat watching them.","article-title":"Footprints of crime Exactly 300 years ago, in 1685, two brothers quarrelled over a \"worthless woman\" and fought a duel in Southampton Fields. The spot has since become familiar to visitors to BMA House under the name of Tavistock Square. In their frenzy the brothers trampled the grass until one of them fell mortally wounded in an agonised posture on the ground. The woman meanwhile watched them from a nearby bank. According to legend the depression made in the ground by the dead brother's body and their footmarks in the turf were visible as bare hollows a century later. A letter dated 1778 and published in the Gentleman's Magazine in 1804 recounts the story and tells how the traces remained on the ground despite attempts to obliterate them by ploughing. The writer of that letter had visited the spot and there saw, in addition to the duellists' traces, a hollow where the woman was supposed to have sat watching them"},{"key":"ref_33","unstructured":"Hip replacement patients have an exclusive golfing society and converge on the Royal Berkshire or some comparable course for an annual meeting, all wearing a special tie and zealous to win the competition. Knee replacements are at present relatively few compared with the assembly line flow of hip prostheses. For this reason I propose to suggest that at this stage a wealthy member of my club should present a cup for members who have had a knee replacement: the match to be played over five holes, preferably from the ladies' tee, and on ground as level as a cricket pitch. By the springtime I shall be, I hope, a deadly chipper and putter, and as at present I am the only player eligible to enter this competition there is a strong probability that I shall win the trophy. I have waited a long time to see a silver cup gleaming on my sideboard.-PETER BEATTIE, Norwich.","article-title":"Hip replacement patients have an exclusive golfing society and converge on the Royal Berkshire or some comparable course for an annual meeting, all wearing a special tie and zealous to win the competition. Knee replacements are at present relatively few compared with the assembly line flow of hip prostheses. For this reason I propose to suggest that at this stage a wealthy member of my club should present a cup for members who have had a knee replacement: the match to be played over five holes, preferably from the ladies' tee, and on ground as level as a cricket pitch. By the springtime I shall be, I hope, a deadly chipper and putter, and as at present I am the only player eligible to enter this competition there is a strong probability that I shall win the trophy. I have waited a long time to see a silver cup gleaming on my sideboard.-PETER BEATTIE"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.291.6508.1550","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.291.6508.1550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:31:56Z","timestamp":1765481516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.291.6508.1550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11,30]]},"references-count":33,"journal-issue":{"issue":"6508","published-online":{"date-parts":[[1985,11,30]]},"published-print":{"date-parts":[[1985,11,30]]}},"alternative-id":["10.1136\/bmj.291.6508.1550"],"URL":"https:\/\/doi.org\/10.1136\/bmj.291.6508.1550","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1985,11,30]]}}}