{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:20:39Z","timestamp":1790130039962,"version":"4.0.1"},"reference-count":8,"publisher":"BMJ","issue":"6514","license":[{"start":{"date-parts":[[1986,1,18]],"date-time":"1986-01-18T00:00:00Z","timestamp":506390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,1,18]]},"abstract":"<jats:p>Lactose tolerance tests were performed in 33 women with osteoporosis and 33 control women matched for age. A questionnaire was used to elicit any history of milk intolerance and the subjects' daily intake of calcium derived from milk and dairy products. Eleven patients and four controls gave a history of milk intolerance (p less than 0.01); 13 patients had lactose malabsorption compared with four controls (p less than 0.01). The daily intake of calcium derived from milk was significantly lower in patients (125 (SEM 20) mg v 252 (43) mg; p less than 0.05). Curves of blood glucose concentrations during the lactose tolerance test in subjects with lactose malabsorption were significantly flatter in patients than controls (p less than 0.05). The fasting blood glucose concentration was higher (5.44 (0.17) mmol\/l (98 (3) mg\/100 ml) in the patients than the controls (4.88 (0.11) mmol\/l (88 (2) mg\/100 ml); p less than 0.05), although body weight was significantly lower (61.6 (2.2) kg v 66.3 (1.6) kg; p less than 0.05). Absorption of lactose is significantly impaired in women with \"idiopathic\" osteoporosis; this combined with low consumption of milk and a subclinical disorder of glucose metabolism may be a major factor in the development of idiopathic osteoporosis in women.<\/jats:p>","DOI":"10.1136\/bmj.292.6514.161","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"161-162","source":"Crossref","is-referenced-by-count":47,"title":["Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis."],"prefix":"10.1136","volume":"292","author":[{"given":"G","family":"Finkenstedt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Skrabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R W","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Braunsteiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM196702232760805","article-title":"Osteoporosis, intestinal lactase deficiency and low dietary calcium intake","volume":"276","author":"SJ, I.Birge; HT, Keutmann; P, Cuatrecasas; GD, Whedon","year":"1967","unstructured":"I Birge SJ, Keutmann HT, Cuatrecasas P, Whedon GD. Osteoporosis, intestinal lactase deficiency and low dietary calcium intake. N Engl Med 1967;276:445-8.","journal-title":"N Engl Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.7326\/0003-4819-89-2-218","article-title":"Lactase deficiency: prevalence in osteoporosis","volume":"89","author":"Newcomer, A.D.; Hodgson, F.S.; McGill, D.B.; Thomas, P.J.","year":"1978","unstructured":"Newcomer AD, Hodgson FS, McGill DB, Thomas PJ. Lactase deficiency: prevalence in osteoporosis. Ann Intem Med 1978;89:218-20.","journal-title":"Ann Intem Med"},{"key":"ref_3","first-page":"281","article-title":"Lactose malabsorption and bone mineral content","author":"Alhava, E.M.; Jussila, J.; Karialainen, P.; Vuojolahti, P.","year":"1977","unstructured":"Alhava EM, Jussila J, Karialainen P, Vuojolahti P. Lactose malabsorption and bone mineral content. Acta Med Scand 1977;201:281-3.","journal-title":"Acta Med Scand"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7326\/0003-4819-77-1-63","article-title":"Femoral trabecular pattern index for evaluation of spinal osteoporosis","volume":"77","author":"Singh, M.; Riggs, B.L.; Beabout, J.W.; Jowsey, J.","year":"1972","unstructured":"Singh M, Riggs BL, Beabout JW, Jowsey J. Femoral trabecular pattern index for evaluation of spinal osteoporosis. Ann Inten Med 1972;77:63-7.","journal-title":"Ann Inten Med"},{"key":"ref_5","article-title":"Disorders of absorption","volume-title":"Harmon's principles of internal medicine","author":"Greenberger, N.J.; Isselbacher, K.J.","unstructured":"Greenberger NJ, Isselbacher KJ. Disorders of absorption. In: Petersdorf RG, Adams RD, Braunwald E, e al, eds. Harmon's principles of internal medicine. New York: McGraw-Hill, 1983: 1735."},{"key":"ref_6","article-title":"Food composition and nutritional tables","author":"Souci, S.W.; Fachmnann, W.V.; Kraut, H.","year":"1981","unstructured":"Souci SW, Fachmnann WV, Kraut H. Food composition and nutritional tables. Stuttgart: Wissenschaftliche Verlagagesellachaft, 1981."},{"key":"ref_7","first-page":"307","article-title":"Osteoporosis: pathogenesis and therapy","author":"Avioli, L.V.","year":"1977","unstructured":"Avioli LV. Osteoporosis: pathogenesis and therapy. In: Avioli AV, Krane SM, eds. Meaabolic bone disease. New York: Academic Press, 1977:307."},{"key":"ref_8","article-title":"Accepted 24","year":"1985","unstructured":"(Accepted 24 October 1985)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6514.161","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6514.161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T19:58:25Z","timestamp":1765483105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6514.161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1,18]]},"references-count":8,"journal-issue":{"issue":"6514","published-online":{"date-parts":[[1986,1,18]]},"published-print":{"date-parts":[[1986,1,18]]}},"alternative-id":["10.1136\/bmj.292.6514.161"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6514.161","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1,18]]}}}