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The saline controlled seizures in all patients, increasing the mean serum sodium concentration by 7.4 (SD 1.14) mmol(mEq)\/l and decreasing the mean serum potassium concentration by 0.62 (0.5) mmol(mEq)\/l. Further saline and frusemide were then administered over 10 (2) hours, raising the serum sodium concentration by 2.14 (0.49) mmol\/l\/h until it reached 133 (2.35) mmol\/l. A total of 790 (139) mmol saline was infused and a negative fluid balance of 3.34 (0.75) litres achieved. Four patients survived without neurological abnormality. One patient, who was not treated immediately and suffered a prolonged episode of status epilepticus, was left with a permanent neurological defect.<\/jats:p>","DOI":"10.1136\/bmj.292.6514.168","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"168-170","source":"Crossref","is-referenced-by-count":85,"title":["Treatment of hyponatraemic seizures with intravenous 29.2% saline."],"prefix":"10.1136","volume":"292","author":[{"given":"L I","family":"Worthley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P D","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0300-595X(84)80022-5","article-title":"Central nervous system manifestations of disordered sodium metabolism","volume":"13","author":"Arieff, A.I.","year":"1984","unstructured":"Arieff AI. 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