{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T16:45:29Z","timestamp":1777221929552,"version":"3.51.4"},"reference-count":15,"publisher":"BMJ","issue":"6517","license":[{"start":{"date-parts":[[1986,2,8]],"date-time":"1986-02-08T00:00:00Z","timestamp":508204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,2,8]]},"abstract":"<jats:p>Heart rate and arterial blood pressure were monitored in 20 consecutive patients during resuscitation from haemorrhagic shock. The mean blood loss (2.3 (SEM 0.3) 1) corresponded to 36(4)% of their estimated mean blood volume. During shock the mean blood pressure was 81\/55 (3\/2) mm Hg and heart rate 73 (3) beats\/min. Administration of blood and crystalloids resulted in immediate increases to 111\/72 (2\/2) mm Hg and 102 (3) beats\/min followed by steady state values of 131\/79 (6\/3) mm Hg and 82 (2) beats\/min. In three otherwise healthy patients plasma concentrations of the vagally regulated hormone pancreatic polypeptide rose from resting values of 64-77 pmol\/l (272-327 pg\/ml) to 198-280 pmol\/l (842-1190 pg\/ml). These findings suggest that reversible hypotensive hypovolaemic shock is characterised by a decrease in heart rate conceivably reflecting an increase in vagal tone.<\/jats:p>","DOI":"10.1136\/bmj.292.6517.364","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"364-366","source":"Crossref","is-referenced-by-count":85,"title":["Vagal slowing of the heart during haemorrhage: observations from 20 consecutive hypotensive patients."],"prefix":"10.1136","volume":"292","author":[{"given":"K","family":"Sander-Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N H","family":"Secher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Warberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T W","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,2,8]]},"reference":[{"key":"ref_1","first-page":"968","article-title":"adjustments to ana ses. In: HaNdIV* of pAyaiely","author":"Wsshington, DC: American al Society","year":"1984","unstructured":"adjustments to ana ses. In: HaNdIV* of pAyaiely. Wsshington, DC: American al Society, 1984:968-1025."},{"key":"ref_2","first-page":"395403","article-title":"Tmroke of vg ardiac nev and arterial ts in the cruatory adjus t ohooha n the cat","volume":"U::","author":"Ob, rg White S.","year":"1970","unstructured":"Ob,rg White S. Tmroke of vg ardiac nev and arterial ts in the cruatory adjus t ohooha n the cat. ActaPIysW Scaud 1970;U::395403.","journal-title":"ActaPIysW Scaud"},{"key":"ref_3","first-page":"315","article-title":"Clisie 1985; S","unstructured":"Clisie 1985;S:315-23."},{"key":"ref_4","first-page":"652","article-title":"S n d pshologicrupture ofthed ten","volume":"114","author":"HyunBH, S.; CF, Varp; RubinRJ, PlinfieldNJ","year":"1972","unstructured":"S HyunBH, Varp CF, RubinRJ,PlinfieldNJ. S n d pshologicrupture ofthed ten. ArcAStsg 1972;114:652-7.","journal-title":"ArcAStsg"},{"key":"ref_5","first-page":"20648","article-title":"Relative bdadis: a sgn of acute inerperitoneal bleding. Awt NZ.7 Obsta Gyusa","volume":"18","author":"Jaen, I.S.","year":"1978","unstructured":"Jaen IS. Relative bdadis: a sgn of acute inerperitoneal bleding. Awt NZ.7 Obsta Gyusa 1978;18:20648."},{"key":"ref_6","first-page":"267","article-title":"Brdydis during vre but reversiblehypov:olmic shock inman","volume":"14","author":"Secher, N.H.; Sander-Jensen, K.; Werner, C.; Warberg, J.; Bie, P.","year":"1984","unstructured":"Secher NH, Sander-Jensen K, Werner C, Warberg J, Bie P. Brdydis during vre but reversiblehypov:olmic shock inman. Circ Shock 1984;14:267-74.","journal-title":"Circ Shock"},{"key":"ref_7","first-page":"524","article-title":"Ruptue of the spleen. A review and report of a cae following abdominal hysterectomy","volume":"133","author":"Hoffma, R.L.","year":"1972","unstructured":"Hoffma RL. Ruptue of the spleen. A review and report of a cae following abdominal hysterectomy.Amj Obstea Gysod 1972;133:524-8.","journal-title":"Amj Obstea Gysod"},{"key":"ref_8","first-page":"1411","article-title":"Pancreatic a hormone under val control. Gasicsarolr 1983; 85","author":"Schdwtz, T.V.","unstructured":"Schdwtz TV. Pancreatic a hormone under val control. Gasicsarolr 1983;85:1411-25."},{"key":"ref_9","first-page":"57","article-title":"nvolvementofvamopress-mincrdio ularregulation","volume":"19","author":"Bennett?, T.; GadinarSM","year":"1985","unstructured":"Bennett?T,GadinarSM. nvolvementofvamopress-mincrdio ularregulation. CaliovawRes 1985;19:57-688.t","journal-title":"CaliovawRes"},{"key":"ref_10","first-page":"10","article-title":"Henodynamic ffet of synthetic arginine v_sopraininsnmn[Abstctj","volume":"121","author":"Bie, P.; Astr, A.; Secber, N.H.; Sander-lenJen, K.; Waberg, J.","year":"1984","unstructured":"Bie P, Astr A, Secber NH, Sander-lenJen K, Waberg J. Henodynamic ffet of synthetic arginine v_sopraininsnmn[Abstctj. Acta PIJWsiaSid 1984;121:10a.","journal-title":"Acta PIJWsiaSid"},{"key":"ref_11","first-page":"1544","article-title":"HJis","volume":"i:","author":"Krarup, T.; Schwartz-T.","year":"1979","unstructured":"Krarup T, Schwartz-T, HJis d J, a Vaveria 0, Sestoft L. Impaired respons of panretic podpepide to hylycaia: an early sign ofautonomi nerepathy in diabetcs. BrMcd, 1979;i:1544-6.","journal-title":"BrMcd; Impaired respons of panretic podpepide to hylycaia: an early sign ofautonomi nerepathy in diabetcs"},{"issue":"7","key":"ref_12","first-page":"329","article-title":"Cinit iooaidrcasuilties","volume":"293","author":"G~tRT, S.; R.*e","year":"1941","unstructured":"S G~tRT,R*e. Cinit iooaidrcasuilties. BrMsd 1941;i:293-7, 329-32.","journal-title":"BrMsd"},{"key":"ref_13","first-page":"31","article-title":"Aboutt he etictivityitrm dunghemorrhagei dicaeedbyheartrateand blood levelsofccls a Absuract","volume":"123","author":"li dlJ","year":"1985","unstructured":"li dlJ,Aboutt he etictivityitrm dunghemorrhagei dicaeedbyheartrateand blood levelsofccls a Absuract. AcstaPhysiilScand 1985;123:31a.","journal-title":"AcstaPhysiilScand"},{"key":"ref_14","article-title":"RoleofcrdiavalCfibersincardioiacularcontrol. RE*PkysioJBWiocPhJIacol 1979;*1-94","author":"ThorEnP","unstructured":"ThorEnP. RoleofcrdiavalCfibersincardioiacularcontrol. RE*PkysioJBWiocPhJIacol 1979;*1-94."},{"key":"ref_15","first-page":"355","article-title":"We must congratulate the jury on its courage and pertinacity; and we trust that examples will not be wanting, to show that the citizens who are called upon t act in this responsible and thankless capacity are awakening to a sense of their duties to the public, in a matter of such import as the determining the exact cause of death. It should be remembered that the slightest omissiop or neglect of, it may be, an apparently insignificant detail of evidence, may be the cause of a murder remaning undetected","volume":"i:","year":"1886","unstructured":"We must congratulate the jury on its courage and pertinacity; and we trust that examples will not be wanting, to show that the citizens who are called upon t act in this responsible and thankless capacity are awakening to a sense of their duties to the public, in a matter of such import as the determining the exact cause of death. It should be remembered that the slightest omissiop or neglect of, it may be, an apparently insignificant detail of evidence, may be the cause of a murder remaning undetected. (British Medicaljournal 1886;i:355.)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6517.364","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6517.364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:11:27Z","timestamp":1765483887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6517.364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,8]]},"references-count":15,"journal-issue":{"issue":"6517","published-online":{"date-parts":[[1986,2,8]]},"published-print":{"date-parts":[[1986,2,8]]}},"alternative-id":["10.1136\/bmj.292.6517.364"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6517.364","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2,8]]}}}