{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:21:28Z","timestamp":1765484488946,"version":"3.48.0"},"reference-count":13,"publisher":"BMJ","issue":"6518","license":[{"start":{"date-parts":[[1986,2,15]],"date-time":"1986-02-15T00:00:00Z","timestamp":508809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,2,15]]},"abstract":"<jats:p>A young woman with recurrent deep venous thromboses and spontaneous abortions was studied. She suffered an ovarian infarction followed by aortic thrombosis and renal failure. Evidence for deficient prostacyclin production was found and she responded to treatment with a prostacyclin infusion. This syndrome is identical with that seen in women with the lupus anticoagulant, but the lupus anticoagulant was not detected and no other cause was identified.<\/jats:p>","DOI":"10.1136\/bmj.292.6518.435","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"435-436","source":"Crossref","is-referenced-by-count":5,"title":["Prostacyclin deficiency in a young woman with recurrent thrombosis."],"prefix":"10.1136","volume":"292","author":[{"given":"J G","family":"Lanham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Gharavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G C","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,2,15]]},"reference":[{"key":"ref_1","first-page":"1021","article-title":"Thrombosis in systemic lupus erythematosus: strilting association with the presence of circulating \"lupus anticoagulant.\"","volume":"287","author":"LM, I.Boey; CB, Colaco; AE, Gharavi; KB, Elkon; S, Loizou; GRV, Hughes","year":"1983","unstructured":"I Boey LM, Colaco CB, Gharavi AE, Elkon KB, Loizou S, Hughes GRV. Thrombosis in systemic lupus erythematosus: strilting association with the presence of circulating \"lupus anticoagulant.\" BrMedJ 1983;287:1021-3.","journal-title":"BrMedJ"},{"key":"ref_2","first-page":"38","article-title":"\"Lupus\" anticoagulant and thrombosis: possible role ofinhibition of prostacyclin formation","volume":"48","author":"Carreras, L.O.; Vermylen, J.G.","year":"1982","unstructured":"Carreras LO, Vermylen JG. \"Lupus\" anticoagulant and thrombosis: possible role ofinhibition of prostacyclin formation. ThrombHaemost 1982;48:38-40.","journal-title":"ThrombHaemost"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/adc.58.9.703","article-title":"Inhibitor of prostacyclin production in sporadic haemolirtic-uraemic syndrome","volume":"58","author":"Levin, M.; Elkon, K.B.; Noakes, T.G.C.","year":"1983","unstructured":"Levin M, Elkon KB, Noakes TGC, et al. Inhibitor of prostacyclin production in sporadic haemolirtic-uraemic syndrome. Arch Dis Child 1983;58:703-8.","journal-title":"Arch Dis Child"},{"key":"ref_4","first-page":"291","article-title":"Intermittent claudication in pre-menopausal women: a correlation with the long-term use of oral contraceptives. J7 Cardiowsc Surg","volume":"18","author":"TJMV, Van Vroonhaven","year":"1977","unstructured":"Van Vroonhaven TJMV. Intermittent claudication in pre-menopausal women: a correlation with the long-term use of oral contraceptives. J7 Cardiowsc Surg (Torino) 1977;18:291-5.","journal-title":"(Torino)"},{"key":"ref_5","first-page":"251","article-title":"Homocystinuria presenting as multiple arterial occlusions","volume":"210","author":"Newman, G.; Mitchell, J.R.A.","year":"1984","unstructured":"Newman G, Mitchell JRA. Homocystinuria presenting as multiple arterial occlusions. QJr Med 1984;210:251-8.","journal-title":"QJr Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1001\/jama.1981.03310420049031","article-title":"Acute aortic thrombosis in anti-thrombin III deficiency","volume":"245","author":"Shapiro, M.E.; W, Salzman E.","year":"1981","unstructured":"Shapiro ME, Salzman E.W. Acute aortic thrombosis in anti-thrombin III deficiency. JAMA 1981;245:1759-61.","journal-title":"JAMA"},{"key":"ref_7","first-page":"610","article-title":"The middle aortic arch syndrome","volume-title":"Br Heart I","volume":"25","author":"Sen, P.K.; Kinare, S.G.; Enginoer, S.D.; Parukar, G.B.","year":"1963","unstructured":"Sen PK, Kinare SG, Enginoer SD, Parukar GB. The middle aortic arch syndrome. Br Heart I 1963;25:610-8."},{"key":"ref_8","first-page":"1211","article-title":"Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus","volume":"ii:","author":"Harris, E.N.; Gharavi, A.E.; Bosy, M.L.; et at","year":"1983","unstructured":"Harris EN, Gharavi AE, Bosy ML, et at. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983;ii: 1211-4.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1172\/JCI109869","article-title":"Monoclonal immunoglobulin M coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant","volume":"6","author":"Thiagarajan, P.; Shapiro, S.S.; De Marco, L.","year":"1980","unstructured":"Thiagarajan P, Shapiro SS, De Marco L. Monoclonal immunoglobulin M coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant. J Cliu Invest 1980;6: 397-404.","journal-title":"J Cliu Invest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(81)92298-4","article-title":"Decreased prostacyclin production: a characteristic of chronic placental insufficiency syndrome","volume":"i:","author":"Stuart, M.J.; Clark, D.A.; Sunderji, S.G.","year":"1981","unstructured":"Stuart MJ, Clark DA, Sunderji SG, et al. Decreased prostacyclin production: a characteristic of chronic placental insufficiency syndrome. Lancet 1981;i:1126-8.","journal-title":"Lancet"},{"key":"ref_11","first-page":"1361","article-title":"Fetal survival after prednisone suppression of maternal lupus anticoagulant","volume":"i:","author":"Lubbe, W.F.; Buder, W.S.; Palmer, S.J.; Liggins, G.C.","year":"1983","unstructured":"Lubbe WF, Buder WS, Palmer SJ, Liggins GC. Fetal survival after prednisone suppression of maternal lupus anticoagulant. Lancet 1983;i:1361-3.","journal-title":"Lancet"},{"article-title":"Accepted","year":"1985","key":"ref_12","unstructured":"(Accepted 22 October 1985)"},{"key":"ref_13","first-page":"123","article-title":"A firm of manufacturers of \"snon-alcoholic\" wines, Messrs. Turley, who are said to havre done an extensive business, were lately summoned by the excise authorities at Birmingham for selling intoxicazingliquors without a licence. These wines (port and sherry), though guaranteed free from alcohol, were found, on analysis at Somerset House, to contain respectivrely 17 and 19 per cent. of alcohol","volume":"i:","year":"1886","unstructured":"A firm of manufacturers of \"snon-alcoholic\" wines, Messrs. Turley, who are said to havre done an extensive business, were lately summoned by the excise authorities at Birmingham for selling intoxicazingliquors without a licence. These wines (port and sherry), though guaranteed free from alcohol, were found, on analysis at Somerset House, to contain respectivrely 17 and 19 per cent. of alcohol. (British MedicalJrournal 1886;i: 123.)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6518.435","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6518.435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:16:28Z","timestamp":1765484188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6518.435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,15]]},"references-count":13,"journal-issue":{"issue":"6518","published-online":{"date-parts":[[1986,2,15]]},"published-print":{"date-parts":[[1986,2,15]]}},"alternative-id":["10.1136\/bmj.292.6518.435"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6518.435","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1986,2,15]]}}}