{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:51Z","timestamp":1790172771414,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","issue":"6522","license":[{"start":{"date-parts":[[1986,3,15]],"date-time":"1986-03-15T00:00:00Z","timestamp":511228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,3,15]]},"abstract":"<jats:p>Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied. In five cases agranulocytosis was combined with liver damage, and in one case of primary liver damage moderate neutropenia was present. Three patients died. High total doses or prolonged duration of treatment, or both, appear to favour the occurrence of these reactions. The clustering of five of the seven cases of agranulocytosis within six months in one medical centre indicates that the risk to benefit ratio of amodiaquine for malaria prophylaxis should be re-evaluated.<\/jats:p>","DOI":"10.1136\/bmj.292.6522.721","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"721-723","source":"Crossref","is-referenced-by-count":233,"title":["Amodiaquine induced agranulocytosis and liver damage."],"prefix":"10.1136","volume":"292","author":[{"given":"K A","family":"Neftel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Woodtly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G","family":"Frick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,3,15]]},"reference":[{"key":"ref_1","first-page":"26","article-title":"Evaluation of amodiaquine (Camoquin) in the treatment of relapsing vivarsmalaria","volume":"225","author":"J, I.Love; R, Foulk; RGW, Willims; RB, Mitchell","year":"1953","unstructured":"I Love J, Foulk R, Willims RGW, Mitchell RB. Evaluation of amodiaquine (Camoquin) in the treatment of relapsing vivarsmalaria. Am_JMedSi 1953;225:26-33.","journal-title":"Am_JMedSi"},{"key":"ref_2","first-page":"475","article-title":"Absolute neutrophil leucopenia after uncontrolled use of amodiaquine","volume":"i:","author":"Kennedy, A.F.","year":"1955","unstructured":"Kennedy AF. Absolute neutrophil leucopenia after uncontrolled use of amodiaquine. BrMedJ 1955;i:475-6.","journal-title":"BrMedJ"},{"key":"ref_3","first-page":"932","article-title":"Fatal a osis durinttreatmentwith amedia","volume":"i:","author":"Glick, L.","year":"1957","unstructured":"' Glick L. Fatal a osis durinttreatmentwith amedia. BrMedj 1957;i:932.","journal-title":"BrMedj"},{"key":"ref_4","first-page":"886","article-title":"Amodlaquine and hydroxychloroquine in rheumatoid arthni","volume":"ii:","author":"Keraly, G.D.","year":"1959","unstructured":"Keraly GD. Amodlaquine and hydroxychloroquine in rheumatoid arthni. Lancet 1959;ii: 886.8..","journal-title":"Lancet"},{"issue":"179","key":"ref_5","first-page":"598","article-title":"INrry' fatal reaction to J","volume":"1962","author":"PeEry, H.O.; Barthilomew, L.G.; Hsnlon, D.G.","unstructured":"PeEry HO, Barthilomew LG, Hsnlon DG.INrry' fatal reaction to J. JAMA 1962;179:598.6.1.","journal-title":"JAMA"},{"key":"ref_6","first-page":"32","volume":"i:","year":"1967","unstructured":"Booth K, Larkin K, Maddocks I Agranulocytosia coisidot-withamodiaquine therpy. BrMAed 1967;i: 32-3."},{"key":"ref_7","first-page":"298","article-title":"A m _ranctosi","volume":"1977","author":"Gilespie, P.; WagerF","unstructured":"Gilespie P, WagerF. A m _ranctosi. MedjAas 1977;:298-9.","journal-title":"MedjAas"},{"key":"ref_8","first-page":"2827","article-title":"Agmnulcytose I'","volume-title":"ui. No Presse Med","volume":"10","author":"Lepeu, G.; Codine, P.; Janbon Bet, A.","year":"1981","unstructured":"Lepeu G, Codine P, Janbon Bet A. Agmnulcytose I' ui. No Presse Med 1981;10:2827-8."},{"key":"ref_9","first-page":"2396","article-title":"Te effect of amodiaqe (Camoquin) on the cqurse ofrheumatoid arthritis","author":"Poweroy, H.; WarrenC, Mils; D, Clark; G.M.","year":"1959","unstructured":"Poweroy H, WarrenC, Mils D, Clark GM. Te effect of amodiaqe (Camoquin) on the cqurse ofrheumatoid arthritis. ArthritisRe 1959;2396-402.","journal-title":"ArthritisRe"},{"key":"ref_10","article-title":"SdaeizMed Wcheashr 1983; 113: 1912.3","author":"Gtanulotn","year":"14","unstructured":"Gtanulotn. SdaeizMed Wcheashr 1983;113:1912.3, 14"},{"key":"ref_11","first-page":"545","article-title":"CliuRhe Dis 1980; 6","unstructured":"*-CliuRhe Dis 1980;6:545-66."},{"key":"ref_12","first-page":"107","article-title":"In vitro inhibition ofprotein synthesis in the retinal pigment epithelium bychloroquine","volume":"13","author":"Gonasun, L.M.; Potts, A.M.","year":"1974","unstructured":"Gonasun LM, Potts AM. In vitro inhibition ofprotein synthesis in the retinal pigment epithelium bychloroquine. Ieuig.Ophkhaba 1974;13:107-15.","journal-title":"Ieuig. Ophkhaba"},{"key":"ref_13","first-page":"40","article-title":"Der bilirubinotagtiscbe Ikteua-ene nesse Iktruform beim Zusammen-.trefa von O>peation, NekrGsi und, BlEsrssfdn","author":"Pclmyr, I.; Stich, W.","year":"1962","unstructured":"Pclmyr I, Stich W. Der bilirubinotagtiscbe Ikteua-ene nesse Iktruform beim Zusammen-.trefa von O>peation, NekrGsi und,BlEsrssfdn. Kfu WEockmschr 1962;40-C65-7.","journal-title":"Kfu WEockmschr"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6522.721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6522.721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:24:11Z","timestamp":1765542251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6522.721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3,15]]},"references-count":13,"journal-issue":{"issue":"6522","published-online":{"date-parts":[[1986,3,15]]},"published-print":{"date-parts":[[1986,3,15]]}},"alternative-id":["10.1136\/bmj.292.6522.721"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6522.721","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3,15]]}}}