{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:15:54Z","timestamp":1787242554767,"version":"build-2736575974"},"reference-count":24,"publisher":"BMJ","issue":"6522","license":[{"start":{"date-parts":[[1986,3,15]],"date-time":"1986-03-15T00:00:00Z","timestamp":511228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,3,15]]},"abstract":"<jats:p>The sickle cell diseases are a major health problem for Afro-Caribbean peoples. Neonatal detection and prophylactic management can reduce mortality and morbidity in childhood. A study was therefore conducted analysing the results of the first two years of cord blood screening in the Camberwell health area. Thirteen cases of sickle cell disease and two of haemoglobin (Hb)C disease were identified among 2202 non-white infants screened. The carrier state, sickle cell trait (HbAS), was present in 11.9% and HbC trait (HbAC) in 4.1% of Afro-Caribbean infants. The incidence of disease and of carrier states was much higher in West Africans than in Caribbeans. The wider implications of screening and the need for a comprehensive plan of care are emphasised.<\/jats:p>","DOI":"10.1136\/bmj.292.6522.737","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"737-740","source":"Crossref","is-referenced-by-count":22,"title":["Neonatal screening for sickle cell diseases in Camberwell: results and recommendations of a two year pilot study."],"prefix":"10.1136","volume":"292","author":[{"given":"M E","family":"Horn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L R","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Bellingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Stroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Studd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archinte.1974.00320160105009","article-title":"The sickle cell diseases","volume":"133","author":"Konotey-Ahulu, F.I.D.","year":"1974","unstructured":"Konotey-Ahulu FID. The sickle cell diseases. Arch IntemMed 1974;133:611-9.","journal-title":"Arch IntemMed"},{"key":"ref_2","first-page":"1515","article-title":"Early deaths in Jamaican children with sickle cell disease","volume":"i:","author":"Rogers, D.W.; Clarke, J.M.; Cupidore, L.; Ramlal, A.M.; Sparke, B.R.; Serjeant, G.R.","year":"1978","unstructured":"Rogers DW, Clarke JM, Cupidore L, Ramlal AM, Sparke BR, Serjeant GR. Early deaths in Jamaican children with sickle cell disease. BrMedJ 1978;i: 1515-6.","journal-title":"BrMedJ"},{"key":"ref_3","first-page":"267","article-title":"Natural history of sickle cell disease-the first ten years","volume":"12","author":"Powars, DR","year":"1975","unstructured":"Powars DR. Natural history of sickle cell disease-the first ten years. Setin Hemawol 1975;12: 267-85.","journal-title":"Setin Hemawol"},{"key":"ref_4","first-page":"1519","article-title":"Survey of sickle cell disease in England and Wales","volume":"283","author":"Davis, L.R.; Huehns, E.R.; White, J.M.","year":"1981","unstructured":"Davis LR, Huehns ER, White JM. Survey of sickle cell disease in England and Wales. BrMedJ 1981;283:1519-21.","journal-title":"BrMedJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood.V53.3.358.358","article-title":"Developmeiital aspects of splenic function in sickle cell diseases","volume":"53","author":"Pearson, H.A.; McIntosh, S.; Ritchey, A.K.; Lobel, J.S.; Rooks, Y.; Johnston, D.","year":"1979","unstructured":"Pearson HA, McIntosh S, Ritchey AK, Lobel JS, Rooks Y, Johnston D. Developmeiital aspects of splenic function in sickle cell diseases. Blood 1979;53:358-65.","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/adc.57.5.338","article-title":"Early rise in 'pitted' red cell count as a guide to susceptibility to infection in childhood sickle cell anaemia","volume":"57","author":"Rogers, D.W.; Serjeant, B.E.; Serjeant, G.R.","year":"1982","unstructured":"Rogers DW, Serjeant BE, Serjeant GR. Early rise in 'pitted' red cell count as a guide to susceptibility to infection in childhood sickle cell anaemia. Arch Dis Child 1982;57:338-42.","journal-title":"Arch Dis Child"},{"issue":"765-9","key":"ref_7","first-page":"386","article-title":"Acute splenic sequestration and hypersplenism in the first five years in childhood sickle cell anaemia","volume":"56","author":"Topley, J.M.; Rogers, D.W.; Stevens, M.C.G.; Sergeant, G.R.","year":"1981","unstructured":"Topley JM, Rogers DW, Stevens MCG, Sergeant GR. Acute splenic sequestration and hypersplenism in the first five years in childhood sickle cell anaemia. Arch Dis Child 1981;56:765-9 8 Sarnaik SA, Lusher JM. Neurological complications of sickle cell anemia. AmJ PediatrHematol Oncol 1982;4:386-94.","journal-title":"Arch Dis Child; Sarnaik SA, Lusher JM. Neurological complications of sickle cell anemia"},{"key":"ref_8","first-page":"744","article-title":"Occurrence of infection with a parvo-virus-like agent in children with sickle cell anaemia during a two-year period","volume":"35","author":"Anderson, M.J.; Davis, L.R.; Hodgson, J.","year":"1982","unstructured":"Anderson MJ, Davis LR, Hodgson J, et al. 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NEnglJMed 1982;306:1441-6.","journal-title":"NEnglJMed"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/280605a0","article-title":"Embury SH, etal. a-Globin gene organisation in blacks precludes the severe form of a-thalassaemia","volume":"280","author":"Dozy, A.M.; Kan, Y.W.","year":"1979","unstructured":"Dozy AM, Kan YW, Embury SH, etal. a-Globin gene organisation in blacks precludes the severe form of a-thalassaemia. Natre 1979;280:605-7.","journal-title":"Natre"},{"key":"ref_22","article-title":"Sickhe cell anaemia-Who cares?","author":"Prashar 0, Anionwu E, Brozovie M","year":"1985","unstructured":"Prashar 0, Anionwu E, Brozovie M. Sickhe cell anaemia-Who cares? London: The Runnymede Trust, 1985."},{"key":"ref_23","article-title":"Accepted 2","year":"1985","unstructured":"(Accepted 2 December 1985)"},{"key":"ref_24","article-title":"The County of London to witBy Virtue of a Warrant under the Hand and Seal of H N Stafford, Esquire, one of His Majesty's Coroners for the Count ofLonon, You are hereby summoned to be and appear before him on Thursday, the 15th day of February at 9 50 am o'clock precisely in the forenoon at the Coroner's Court 77 Fulham Palace Road Hammersmith then and there to give evidence on His Majesty's behalftouching the death ofS E Joyce Herein fail not at your peril. Dated this 13th day Feb 1940","unstructured":"The County of London to witBy Virtue of a Warrant under the Hand and Seal of H N Stafford, Esquire, one of His Majesty's Coroners for the Count ofLonon, You are hereby summoned to be and appear before him on Thursday, the 15th day of February at 9 50 am o'clock precisely in the forenoon at the Coroner's Court 77 Fulham Palace Road Hammersmith then and there to give evidence on His Majesty's behalftouching the death ofS E Joyce Herein fail not at your peril. Dated this 13th day Feb 1940. D Mitchley CONSTABLE"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6522.737","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6522.737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:25:13Z","timestamp":1765542313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6522.737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3,15]]},"references-count":24,"journal-issue":{"issue":"6522","published-online":{"date-parts":[[1986,3,15]]},"published-print":{"date-parts":[[1986,3,15]]}},"alternative-id":["10.1136\/bmj.292.6522.737"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6522.737","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3,15]]}}}