{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:36:48Z","timestamp":1765543008861,"version":"3.48.0"},"reference-count":6,"publisher":"BMJ","issue":"6524","license":[{"start":{"date-parts":[[1986,3,29]],"date-time":"1986-03-29T00:00:00Z","timestamp":512438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,3,29]]},"abstract":"<jats:p>Recent findings suggest that bacteria might contribute to histamine concentrations in the sputum of patients with infective lung disease. Ten isolates of Haemophilus influenzae from patients with acute exacerbation of chronic bronchitis and emphysema, together with two reference strains, were incubated at 37 degrees C for 72 hours. Serial estimations of histamine concentrations by high pressure liquid chromatography showed significant increases at 24 and 48 hours; no increases were evident in the control samples. These findings suggest that H influenzae might contribute to inflammation and limited airflow in infective lung disease by producing histamine.<\/jats:p>","DOI":"10.1136\/bmj.292.6524.857","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"857-858","source":"Crossref","is-referenced-by-count":27,"title":["Synthesis of histamine by Haemophilus influenzae."],"prefix":"10.1136","volume":"292","author":[{"given":"B D","family":"Sheinman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Devalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Crook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tabaqchali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,3,29]]},"reference":[{"article-title":"De novo generation of histamine in sputum and the effect of antibiotics","author":"Sheinman, B.D.; Devalia, J.L.; Crook, S.J.; Davies, R.J.","key":"ref_1","unstructured":"Sheinman BD, Devalia JL, Crook SJ, Davies RJ. De novo generation of histamine in sputum and the effect of antibiotics. AgensActions (in press)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0378-4347(00)84610-1","article-title":"A new high-performance liquid chromatographic method for the assay of histamine, 1-methyl histamine and other biogenic amines","volume":"343","author":"Devalia, J.L.; Sheinman, B.D.; Davies, R.J.","year":"1985","unstructured":"Devalia JL, Sheinman BD, Davies RJ. A new high-performance liquid chromatographic method for the assay of histamine, 1-methyl histamine and other biogenic amines. J Chromatogr 1985;343:407-12.","journal-title":"J Chromatogr"},{"key":"ref_3","first-page":"173","article-title":"Histamine production by foodborne bacterial species","volume":"1","author":"Taylor, S.L.; Guthertz, L.S.; Leatherwood, M.; Tillman, F.; Lieber, E.R.","year":"1978","unstructured":"Taylor SL, Guthertz LS, Leatherwood M, Tillman F, Lieber ER. 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Effect of histamine and methacholine on guinea-pig tracheal permneability to HRP..7 Appl Physiol 1978;45:939-48.","journal-title":"Physiol"},{"key":"ref_6","first-page":"28","volume":"ii:","author":"oumnal 1886","unstructured":"oumnal 1886;ii:28.)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6524.857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6524.857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:34:11Z","timestamp":1765542851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6524.857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3,29]]},"references-count":6,"journal-issue":{"issue":"6524","published-online":{"date-parts":[[1986,3,29]]},"published-print":{"date-parts":[[1986,3,29]]}},"alternative-id":["10.1136\/bmj.292.6524.857"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6524.857","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1986,3,29]]}}}