{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:20:06Z","timestamp":1783743606745,"version":"3.55.0"},"reference-count":6,"publisher":"BMJ","issue":"6526","license":[{"start":{"date-parts":[[1986,4,12]],"date-time":"1986-04-12T00:00:00Z","timestamp":513648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,4,12]]},"abstract":"<jats:p>Five patients with metastatic pancreatic endocrine tumours injected a long acting somatostatin analogue (SMS 201-995) 50 micrograms subcutaneously every 12 hours and were followed up for three to six months. Treatment aimed at controlling excess secretion of hormone by the tumours thereby bringing symptomatic relief. Four patients showed a significant reduction in tumour related hormone concentrations but in none did values return to normal. All five patients, however, noted definite symptomatic improvement and in one this was dramatic (disappearance of life threatening diarrhoea and correction of metabolic acidosis and hypokalaemia within 48 hours). Mild worsening of symptoms and increasing fasting tumour related hormone concentrations after three to six months of treatment were reversed by doubling the 12 hourly dose. The treatment was well tolerated and had no deleterious effect on fasting blood glucose concentrations. This somatostatin analogue seems a promising non-invasive treatment for metastatic pancreatic endocrine tumours.<\/jats:p>","DOI":"10.1136\/bmj.292.6526.981","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"981-982","source":"Crossref","is-referenced-by-count":58,"title":["Remission of symptoms during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue."],"prefix":"10.1136","volume":"292","author":[{"given":"J L","family":"Ch'ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,4,12]]},"reference":[{"key":"ref_1","first-page":"764","article-title":"Suppression of pancreatic endocrine tumour secretion by long-acting somatosttin analogue","author":"Long, R.G.; Barnes, A.J.; Adrian, T.E.","year":"1979","unstructured":"Long RG, Barnes AJ, Adrian TE, et al. Suppression of pancreatic endocrine tumour secretion by long-acting somatosttin analogue. Lancet 1979;ii;764-7.","journal-title":"Lancet"},{"key":"ref_2","article-title":"Radio ius of gut regulato, y pepddes","author":"Bloom, SR, Long; R.G.","year":"1982","unstructured":"Bloom SR, Long RG. Radio ius of gut regulato,y pepddes. London: Saunders, 1982."},{"key":"ref_3","first-page":"185","article-title":"Long-term treatment of a vipoma with somatostatin analogue resulting in remission of symptoms and possible","volume-title":"shrinkage of metastases. Gastroenterology 1985; 88","author":"Kraenzlin, M.E.; Ch'ng, J.L.C.; Wood, S.M.; Carr, D.H.; Bloom, SR","unstructured":"Kraenzlin ME, Ch'ng JLC, Wood SM, Carr DH, Bloom SR. Long-term treatment of a vipoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases. Gastroenterology 1985;88:185-7."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM198501033120104","article-title":"Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera","volume":"312","author":"Maton, P.N.; O'Dorisio, T.M.; Howe, B.A.","year":"1985","unstructured":"Maton PN, O'Dorisio TM, Howe BA, et al. Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera. NEngIlMed 1985;312:17-21.","journal-title":"NEngIlMed"},{"key":"ref_5","first-page":"1027","article-title":"Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea","volume":"289","author":"NS, S.Williams; JC, Cooper; ART, Axon; RFGJ, King; M, Barker","year":"1984","unstructured":"S Williams NS, Cooper JC, Axon ART, King RFGJ, Barker M. Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea. BrMed 1984;289:1027-8.","journal-title":"BrMed"},{"key":"ref_6","article-title":"Accepted 25","year":"1986","unstructured":"(Accepted 25 February 1986)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6526.981","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6526.981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:46:23Z","timestamp":1765543583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6526.981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4,12]]},"references-count":6,"journal-issue":{"issue":"6526","published-online":{"date-parts":[[1986,4,12]]},"published-print":{"date-parts":[[1986,4,12]]}},"alternative-id":["10.1136\/bmj.292.6526.981"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6526.981","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4,12]]}}}