{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:21:37Z","timestamp":1770506497984,"version":"3.49.0"},"reference-count":28,"publisher":"BMJ","issue":"6528","license":[{"start":{"date-parts":[[1986,4,26]],"date-time":"1986-04-26T00:00:00Z","timestamp":514857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,4,26]]},"abstract":"<jats:p>Regional values of bone mineral content and bone mineral density were calculated from total body dual photon absorptiometry scans of 52 early postmenopausal women treated with oestrogen for one year and of 52 similar women treated with placebo. The six regions were head, arms, chest, spine, pelvis, and legs. In addition, bone mineral density of the lumbar spine was measured by dual photon absorptiometry and bone mineral content of the forearm by single photon absorptiometry, using separate special purpose scanners. All regions were unchanged after one year of treatment with oestrogen, excluding the lumbar spine, for which values rose. Values for all regions except the lumbar spine fell significantly in the placebo group. The rates of loss ranged from 2% to 8%, with no significant differences among the regions. It is concluded that loss of bone in the early menopause is a generalised phenomenon, affecting all parts of the skeleton. Furthermore, oestrogen prophylaxis for loss of bone is effective in all parts of the skeleton. Finally, it is suggested that the measurement of bone mineral content in the forearm should be used for clinical follow up of bone changes, as this method is superior to others in the ratio of change to precision.<\/jats:p>","DOI":"10.1136\/bmj.292.6528.1098","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1098-1100","source":"Crossref","is-referenced-by-count":47,"title":["Bone changes occurring spontaneously and caused by estrogen in early postmenopausal women: a local or generalised phenomenon?"],"prefix":"10.1136","volume":"292","author":[{"given":"A","family":"Gotfredsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Nilas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Riis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,4,26]]},"reference":[{"key":"ref_1","first-page":"1824","volume":"44","author":"C, I.Nezelof; F, Frileux-Herbert; J, Cronier Sachat","year":"1979","unstructured":"I Nezelof C, Frileux-Herbert F, Cronier Sachat J. 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Medicine (Balinare) 1981;60:311-37.","journal-title":"Medicine (Balinare)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0002-9343(57)90115-8","article-title":"Course and prognosis of reticuloendotheliosis (eosinophilic granuloma, Schuller-Christian disease and Letterer-Siwe disease)","volume":"22","author":"Avery, M.","year":"1957","unstructured":"Avery M, et al. Course and prognosis of reticuloendotheliosis (eosinophilic granuloma, Schuller-Christian disease and Letterer-Siwe disease). AmJ Med 1957;22:636-52.","journal-title":"AmJ Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(84)90127-2","article-title":"Spontaneous remission of multi-system histiocytoisis X","volume":"i:","author":"Broadbent, V.; Davies, E.G.; Heaf, D.","year":"1984","unstructured":"Broadbent V, Davies EG, Heaf D, et al. Spontaneous remission of multi-system histiocytoisis X. 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Representativity of regional to total bone mineral in healthy subjects and \"anticonvulsive treated\" epileptic patients. Measurements by single and dual photon absorptiometry. EurJ Clin Invest (in press).","journal-title":"ClinicalRheunatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1475-097X.1983.tb00718.x","article-title":"Relationship between local and total body bone mineral in epileptic patients and normal subjects","volume":"3","author":"Tiellesen, L.; Gotfredsen, A.; Borg, J.; Christiansen, C.","year":"1983","unstructured":"Als OS, Gotfredsen A-Christiansen C. Relationship between local and total bone mineral in patients with rheumatoid arthritis and normal subjects. 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Radiology 1980;136:485-7.","journal-title":"Radiology"},{"key":"ref_19","first-page":"323","article-title":"Bone mineral content in the forearm measured by photon absorptiometry. ScandJ7 Cli Lab Invest","volume":"35","author":"Christiansen, C.; Rodbro, P.; Jensen, H.","year":"1975","unstructured":"Wahner HW, Dunn WL, MazessRB, etal. Dual photon 153Gd absorptiometry of bone. Radiology 1985;156:203-6."},{"key":"ref_20","first-page":"800","article-title":"Uncoupling of bone formation\/bone resorption by combined oestrogen\/progestogen therapy in postmenopausal osteoporosis","volume":"i:","author":"Christiansen, C.; Riis, B.J.; Nilas, L.; R0dbro, P.; Deftos, L.","year":"1985","unstructured":"Christiansen C, Rodbro P, Jensen H. Bone mineral content in the forearm measured by photon absorptiometry. ScandJ7 Cli Lab Invest 1975;35:323-30.","journal-title":"Lancet"},{"key":"ref_21","first-page":"311","article-title":"The lossof bone mineral with agingand its relationship to risk of fracture. J7 Clin Invest","volume":"56","author":"Smith, D.M.; Khairi, M.R.A.; CC, Jr, Johnston","year":"1975","unstructured":"Christiansen C, Riis BJ, Nilas L, R0dbro P, Deftos L. Uncoupling of bone formation\/bone resorption by combined oestrogen\/progestogen therapy in postmenopausal osteoporosis. Lancet 1985;i:800-1."},{"key":"ref_22","first-page":"91","article-title":"Age related bone loss","author":"CC, Jr, Johnston; JA, Norton; RA, Khairi; C, Longcope","year":"1979","unstructured":"Smith DM, Khairi MRA, Johnston CC Jr. The lossof bone mineral with agingand its relationship to risk of fracture.J7 Clin Invest 1975;56:311-8."},{"key":"ref_23","first-page":"273","article-title":"Prevention of early postmenopausal bone loss","volume":"2","author":"Christiansen, C.; Christensen, M.S.; McNair, P.; Hagen, C.; Stocklund, K.E.; Transbol, I.","year":"1980","unstructured":"Johnston CC Jr, Norton JA, Khairi RA, Longcope C. Age related bone loss. In: Barzel U, ed. Osteoporosis II. New York: Grune and Stratton, 1979:91-100.","journal-title":"EurJ Clin Invest"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/cs0620329","article-title":"Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies","volume":"62","author":"Kr0lner, B.; Pors Nielsen, J.","year":"1982","unstructured":"Christiansen C, Christensen MS, McNair P, Hagen C, Stocklund KE, Transbol I. Prevention of early postmenopausal bone loss. EurJ Clin Invest 1980;2:273-9.","journal-title":"Clin Sci"},{"key":"ref_25","first-page":"543","article-title":"Morphologic analysis in pathology. The kinetics of disease and general biology of bone","author":"Johnson, L.C.","year":"1964","unstructured":"Kr0lner B, Pors Nielsen J. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies. Clin Sci 1982;62:329-36."},{"key":"ref_26","first-page":"1038","article-title":"Long-term prevention of postmenopausal osteoporosis by oestrogen","volume":"i:","author":"Lindsay, R.; Aitken, J.M.; Anderson, J.B.; Hart, D.M.; MacDonald, E.B.; Clarke, A.C.","year":"1976","unstructured":"Johnson LC. Morphologic analysis in pathology. The kinetics of disease and general biology of bone. In: Frost HM, ed. Bone biodynamics. Boston, Massachusetts: Little, Brown and Company, 1964:543-654.","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0140-6736(81)91848-1","article-title":"Bone mass in postmenopausal women after withdrawal of oestrogen\/gestagen replacement therapy","volume":"i:","author":"Christiansen, C.; Christensen, M.S.; Transbol, I.","year":"1981","unstructured":"Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC. Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet 1976;i: 1038-41.","journal-title":"Lancet"},{"key":"ref_28","author":"Accepted","year":"1986","unstructured":"Christiansen C, Christensen MS, Transbol I. Bone mass in postmenopausal women after withdrawal of oestrogen\/gestagen replacement therapy. Lancet 1981;i:459-61."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6528.1098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6528.1098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:52:12Z","timestamp":1765543932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6528.1098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4,26]]},"references-count":28,"journal-issue":{"issue":"6528","published-online":{"date-parts":[[1986,4,26]]},"published-print":{"date-parts":[[1986,4,26]]}},"alternative-id":["10.1136\/bmj.292.6528.1098"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6528.1098","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4,26]]}}}