{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:11:04Z","timestamp":1765545064294,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"6530","license":[{"start":{"date-parts":[[1986,5,10]],"date-time":"1986-05-10T00:00:00Z","timestamp":516067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,5,10]]},"abstract":"<jats:p>The duodenal microflora was studied during the first week of diarrhoea in 40 infants with acute infectious diarrhoea of different aetiologies and compared with that in a convalescent group and a group in whom diarrhoea of known aetiology had persisted for more than 14 days after an acute onset. In the acute phase 16 of the 40 infants had more than 10(4) colony forming bacteria\/ml, predominantly upper respiratory commensals. In over half of the infants infected with enteropathogenic Escherichia coli a faecal type flora was found in the duodenum. This flora included the enteropathogenic E coli serotype isolated from the stool in three quarters of cases. Infants with persisting diarrhoea had significantly more faecal type bacteria in the duodenum than either those with acute diarrhoea or the convalescent group. In addition, there was a significant further increase in Enterobacteriaceae in infants whose persistent diarrhoea occurred after infection with enteropathogenic E coli. Infections with enteropathogenic E coli may have a predilection for disturbing the duodenal microflora, which may contribute to the development of persistent diarrhoea.<\/jats:p>","DOI":"10.1136\/bmj.292.6530.1223","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1223-1226","source":"Crossref","is-referenced-by-count":25,"title":["Bacterial contamination of the small intestine of infants with enteropathogenic Escherichia coli and other enteric infections: a factor in the aetiology of persistent diarrhoea?"],"prefix":"10.1136","volume":"292","author":[{"given":"M E","family":"Penny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Harendra de Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S","family":"McNeish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,5,10]]},"reference":[{"key":"ref_1","article-title":"Infectous agents in acute and chronic diarrhea of childhood","volume-title":"Choic diarhea in chik)re","author":"Mata, L.; Urrutia, J.J.; Simhon, A.","year":"1984","unstructured":"Mata L, Urrutia JJ, Simhon A. Infectous agents in acute and chronic diarrhea of childhood. In: Lebenthal E, ed. Choic diarhea in chik)re. New York: Raven Press, 1984."},{"key":"ref_2","first-page":"445","article-title":"Intractable diarrhoea of infancy","volume":"6","author":"Sunshine, P.; Sinatra, F.R.; Mitchell, C.H.","year":"1977","unstructured":"Sunshine P, Sinatra FR, Mitchell CH. Intractable diarrhoea of infancy. Clii Gasremeol 1977;6:445-61.","journal-title":"Clii Gasremeol"},{"issue":"1","key":"ref_3","first-page":"70","article-title":"Bacteri microflora of the upper pstrointestinal tact in infants with protracted diarrhoea","volume":"4","author":"Challacombe, D.N.; Rihardson, J.M.; Rowe, B.; Anderson, C.M.","year":"1974","unstructured":"Challacombe DN, Rihardson JM, Rowe B, Anderson CM. Bacteri microflora of the upper pstrointestinal tact in infants with protracted diarrhoea. 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Microbial flora ofstomach and small intestine in infantile gastroenteritis, Acta PaediatrScad 1974;63:418-22.","journal-title":"Acta PaediatrScad"},{"key":"ref_12","first-page":"1281","article-title":"Virus paticles in the epithelium of duodenal mucosa frosm children with acute non-bacterial gastoenteritis","volume":"ii:","author":"Bishop, R.F.; Didson, G.P.; Holmes, I.H.; Tuck, B.J.","year":"1973","unstructured":"Bishop RF, Didson GP, Holmes IH, Tuck BJ. Virus paticles in the epithelium of duodenal mucosa frosm children with acute non-bacterial gastoenteritis. Laxca 1973;ii: 1281-3.","journal-title":"Laxca"},{"key":"ref_13","first-page":"589","article-title":"Intestinal dsmage in roevirus and adenovirus pstroenteritis assessed by D-xyloae malabsorpon","volume":"52","author":"Mavromichaelis, J.; Evans, N.; McNeish, A.S.; Bryden, A.S.; Davies, H.A.; Flewett, T.H.","year":"1977","unstructured":"Mavromichaelis J, Evans N, McNeish AS, Bryden AS, Davies HA, Flewett TH. 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Lancet 1978;i 119-22.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM198001103020207","article-title":"Pathogenesis of Escherichia coli gastroeteritis in ma-another mechanism","volume":"302","author":"Ulshen, M.H.; Robo, J.L.","year":"1980","unstructured":"Ulshen MH, Robo JL. Pathogenesis of Escherichia coli gastroeteritis in ma-another mechanism. NEnglJrMed 1980;302:99-101.","journal-title":"NEnglJrMed"},{"key":"ref_20","first-page":"441","article-title":"A clinicopathological study of enterocyteadherent Escherichia coli: a cause of protracted diarrhea in infants","volume":"83","author":"Rothbaum, R.; McAdams, A.J.; Giannella, R.; Partin, J.C.","year":"1982","unstructured":"Rothbaum R, McAdams AJ, Giannella R, Partin JC. A clinicopathological study of enterocyteadherent Escherichia coli: a cause of protracted diarrhea in infants. Gastoenxeolg 1982;83: 441-54.","journal-title":"Gastoenxeolg"},{"article-title":"In vitro adhesion of enteropathogenic Escherichia coli to intestinal cells","author":"Knutton, S.; Baldini, M.M.; Lloyd, D.R.; Candy, D.C.A.; McNeish, A.S.","key":"ref_21","unstructured":"Knutton S, Baldini MM, Lloyd DR, Candy DCA, McNeish AS. In vitro adhesion of enteropathogenic Escherichia coli to intestinal cells. PediairRes (in press)."},{"key":"ref_22","first-page":"221","article-title":"Pathogenic effect of enterotoxigenic Escerichia coli and Ewcherichia coli causing infantile diarrhoea","volume":"24","author":"Polotsky, Y.E.; Dragunskaya, E.M.; Seliverstova, V.B.; a al","year":"1977","unstructured":"Polotsky YE, Dragunskaya EM, Seliverstova VB, a al. Pathogenic effect of enterotoxigenic Escerichia coli and Ewcherichia coli causing infantile diarrhoea. 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Lycc Vjes 1981;103:79-82.","journal-title":"Lycc Vjes"},{"article-title":"Accepted I","year":"1986","key":"ref_29","unstructured":"(Accepted I April 1986)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6530.1223","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6530.1223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:00:19Z","timestamp":1765544419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6530.1223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5,10]]},"references-count":29,"journal-issue":{"issue":"6530","published-online":{"date-parts":[[1986,5,10]]},"published-print":{"date-parts":[[1986,5,10]]}},"alternative-id":["10.1136\/bmj.292.6530.1223"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6530.1223","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"type":"print","value":"0267-0623"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1986,5,10]]}}}