{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:35:49Z","timestamp":1775151349992,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"6530","license":[{"start":{"date-parts":[[1986,5,10]],"date-time":"1986-05-10T00:00:00Z","timestamp":516067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1986,5,10]]},"abstract":"<jats:p>De novo synthesis in the central nervous system of IgG antibodies to human T cell lymphotropic virus type III (HTLV-III) (lymphadenopathy associated virus) was shown in seven of 10 seropositive men who had syphilis but not the acquired immune deficiency syndrome (AIDS) or AIDS related complex. None of these men showed neurological symptoms when the serum and cerebrospinal fluid were collected. Pleocytosis was present in all 10. Of the seven men who showed evidence of intrathecal synthesis of antibodies, five had increased total concentrations of IgG and four had oligoclonal IgG bands in their cerebrospinal fluid. Oligoclonal bands were also present in one man who did not have any antibodies. Longitudinal study of one man showed that seroconversion preceded intrathecal synthesis of antibody specific to HTLV-III. The appearance of antibody in the cerebrospinal fluid was accompanied by a transient rise in mononuclear cell count and the appearance of oligoclonal bands. The presence of clones of B cells specific to HTLV-III in the central nervous system of these patients without persisting neurological symptoms suggests that HTLV-III enters the central nervous system in the early stages of infection.<\/jats:p>","DOI":"10.1136\/bmj.292.6530.1231","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"1231-1234","source":"Crossref","is-referenced-by-count":103,"title":["Intrathecal synthesis of antibodies to HTLV-III in patients without AIDS or AIDS related complex."],"prefix":"10.1136","volume":"292","author":[{"given":"J","family":"Goudsmit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E C","family":"Wolters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Van der Noordaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Hische","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Tutuarima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Van der Helm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,5,10]]},"reference":[{"key":"ref_1","first-page":"498","article-title":"Progressive encephalopathy in children with acquired immune deficiency syndrome","volume":"17","author":"LG, I.Epstein; LR, Sharer; W, Joshi; MM, Foias; MR, Koenings-berger; JM, Oleske","year":"1985","unstructured":"I Epstein LG, Sharer LR, Joshi W, Foias MM, Koenings-berger MR, Oleske JM. Progressive encephalopathy in children with acquired immune deficiency syndrome. Ann Neurol 1985;17: 498-%.","journal-title":"Ann Neurol"},{"issue":"10","key":"ref_2","volume":"292","author":"MEDICAL, B.R.I.T.I.S.H.","year":"1986","unstructured":"BRITISH MEDICAL JOURNAL VOLUmE 292 10 my 1986","journal-title":"JOURNAL"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.2981429","article-title":"HTLV-I1 infection in brains of children and adults with AIDS encephalopathy","volume":"227","author":"Shaw, G.M.; Harper, M.E.; Hahn, B.H.","year":"1985","unstructured":"Shaw GM, Harper ME, Hahn BH, et al. HTLV-I1 infection in brains of children and adults with AIDS encephalopathy. 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Intra blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDSrelated complex. NEngl7Med 1985;313:1498-504."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jmv.1890160213","article-title":"Intrathecal synthesis of IgG antibodies to varicellazoster in two cases ofacute aseptic meningitis syndrome with mucocutaneous lesions","volume":"16","author":"Martinez, P.; Carcia-Saiz, A.; Rapun, J.L.; Echevarria, J.M.","year":"1985","unstructured":"Martinez P, Carcia-Saiz A, Rapun JL, Echevarria JM. Intrathecal synthesis of IgG antibodies to varicellazoster in two cases ofacute aseptic meningitis syndrome with mucocutaneous lesions. J Med Virol 1985;16:201-9.","journal-title":"J Med Virol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0140-6736(81)92744-6","article-title":"Rapid non-invasive diagnosis of herpes encephalitis","volume":"ii:","author":"Klapper, P.E.; Laing, I.; Longson, M.","year":"1981","unstructured":"Klapper PE, Laing I, Longson M. Rapid non-invasive diagnosis of herpes encephalitis. Lancet 1981;ii:607-9.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.410170105","article-title":"IgG production within the central nervous system: a critical review of proposed formulae","volume":"17","author":"Lefvert, A.K.; Link, H.","year":"1985","unstructured":"Lefvert AK, Link H. IgG production within the central nervous system: a critical review of proposed formulae. Ann Neurol 1985;17: 13-20.","journal-title":"Ann Neurol"},{"key":"ref_9","first-page":"385","article-title":"Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand7 Clin Lab Invest","volume":"37","author":"Tibbling, G.; Link, H.; Ohman, S.","year":"1977","unstructured":"Tibbling G, Link H, Ohman S. Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand7 Clin Lab Invest 1977;37:385-90."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/clinchem\/31.8.1417a","article-title":"More precise determination of the cerebrospinal fluid IgG index","volume":"31","author":"Hische, E.A.H.; van Meegen, M.T.; van der Helm, H.J.","year":"1985","unstructured":"Hische EAH, van Meegen MT, van der Helm HJ. More precise determination of the cerebrospinal fluid IgG index. Clin Chem 1985;31:1417.","journal-title":"Clin Chem"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/clinchem\/26.13.1917","article-title":"Monoclonal immunoglobulins demonstrable in cerebrospinal fluid by use ofcellulose acetate electrophoresis","volume":"26","author":"der Helm HJ, Van; EAH, Hische; van Walbeek HK","year":"1980","unstructured":"Van der Helm HJ, Hische EAH, van Walbeek HK. Monoclonal immunoglobulins demonstrable in cerebrospinal fluid by use ofcellulose acetate electrophoresis. Clin Chem 1980;26:1917-8.","journal-title":"Clin Chem"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/ana.410040304","article-title":"The cerebrospinal fluid in visna, a slow viral disease of sheep","volume":"4","year":"1978","unstructured":"Griffin DE, Narayan 0, Bulowski JF, Adams RJ, Cohen SR. The cerebrospinal fluid in visna, a slow viral disease of sheep. 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This is particularly true in France, where alcohol consumption remains one of the highest in the world'0 and where traffic accidents are the major cause of premature death, leading to about I 1 000 deaths each year.\" Furthermore, alcoholconsumption is likely to play a part in other kinds ofaccidents occurring at home, at work, or during leisure or sport activities","author":"Nevertheless","unstructured":").'-9 Nevertheless, the knowledge of this relation, if any, might be of paramount importance in optimising preventive action against accidents. This is particularly true in France, where alcohol consumption remains one of the highest in the world'0 and where traffic accidents are the major cause of premature death, leading to about I 1 000 deaths each year.\" Furthermore, alcoholconsumption is likely to play a part in other kinds ofaccidents occurring at home, at work, or during leisure or sport activities."},{"key":"ref_16","article-title":"To tackle these problems a nationwide epidemiological survey was started in 1982, at the Prime Minister's request, to assess the proportions of occasional and chronic heavy drinkers concerned in accidents. It was decided to measure systematically, in addition to the blood alcohol concentration, the y-glutamyltransferase activity and the mean corpuscular volume, both of which, alone'2 1\" and in combination,'4 correlate reasonably well with usual alcohol intake","unstructured":"To tackle these problems a nationwide epidemiological survey was started in 1982, at the Prime Minister's request, to assess the proportions of occasional and chronic heavy drinkers concerned in accidents. It was decided to measure systematically, in addition to the blood alcohol concentration, the y-glutamyltransferase activity and the mean corpuscular volume, both of which, alone'2 1\" and in combination,'4 correlate reasonably well with usual alcohol intake."},{"key":"ref_17","article-title":"The subjects were recruited from","volume-title":"to March 1983 in the emergency units of 21 hospitals, two in Paris and the other 19 in towns all over France. In each centre the study schedule was planned so that each day, ofthe week and each hour ofthe day were equally represented.. The criteria for inclusion were: (a) that the subject presented, with or without-apparent injury, after an accident of any kind, including traffic accidents, accidents at work, in the home, or during leisure or sporting","year":"1982","unstructured":"The subjects were recruited from October 1982 to March 1983 in the emergency units of 21 hospitals, two in Paris and the other 19 in towns all over France. In each centre the study schedule was planned so that each day, ofthe week and each hour ofthe day were equally represented.. The criteria for inclusion were: (a) that the subject presented, with or without-apparent injury, after an accident of any kind, including traffic accidents, accidents at work, in the home, or during leisure or sporting"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.292.6530.1231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.292.6530.1231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:00:26Z","timestamp":1765544426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.292.6530.1231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5,10]]},"references-count":17,"journal-issue":{"issue":"6530","published-online":{"date-parts":[[1986,5,10]]},"published-print":{"date-parts":[[1986,5,10]]}},"alternative-id":["10.1136\/bmj.292.6530.1231"],"URL":"https:\/\/doi.org\/10.1136\/bmj.292.6530.1231","relation":{},"ISSN":["0267-0623","1468-5833"],"issn-type":[{"value":"0267-0623","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5,10]]}}}