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There was no difference in skin response between patients positive and negative for the human immunodeficiency virus (HIV; formerly known as human T cell lymphotropic virus Im or lymphadenopathy associated virus). In tbe whole group, and in seronegative patients (n= 17), there was aan inverse relation between exposure to clotting factor and skin response. In seropositive patients (n= 12) no such association was apparent","unstructured":"The cell mediated immune response was evaluated in vivo in 29 patients.twith clinically severe haemophilia by means of the dinitrochlorobenzene skin test. All patients had a response below the median normal value, and in 19.the response was on or below the lower limit of the normal range. There was no difference in skin response between patients positive and negative for the human immunodeficiency virus (HIV; formerly known as human T cell lymphotropic virus Im or lymphadenopathy associated virus). In tbe whole group, and in seronegative patients (n= 17), there was aan inverse relation between exposure to clotting factor and skin response. 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