{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:31:46Z","timestamp":1776141106776,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"6589","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1987,7,4]]},"DOI":"10.1136\/bmj.295.6589.7","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T19:19:55Z","timestamp":1238699995000},"page":"7-12","source":"Crossref","is-referenced-by-count":24,"title":["Is changing hypothalamic activity important for control of ovulation?"],"prefix":"10.1136","volume":"295","author":[{"given":"R N","family":"Clayton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Royston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Obhrai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Sawers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"53","article-title":"The neuroendocrine control of the menstrual cycle. Recent Prog Horm","volume":"36","author":"Knobil, E.","year":"1980","unstructured":"Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 1980;36: 53-88.","journal-title":"Res"},{"key":"ref_2","first-page":"563","article-title":"The neuroendocrinology of reproductive disorders","author":"Clayton, R.N.","year":"1986","unstructured":"Clayton RN. The neuroendocrinology of reproductive disorders. In: Lightman SL, Everitt B, eds. Contemporaty neuroendocrnology. Oxford: Blackwell, 1986:563-87."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2265.1987.tb00794.x","article-title":"GnRH: from physiology to pharmacology","volume":"26","author":"Clayton, R.N.","year":"1987","unstructured":"Clayton RN. GnRH: from physiology to pharmacology. Clin Endocrinol 1987;26:361-84.","journal-title":"Clin Endocrinol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2265.1982.tb02631.x","article-title":"Pulsatile secretion of LH, FSH, prolactin, oestradiol and progesterone during the human minstrual cycle","volume":"17","author":"Backstrom, C.T.; McNeilly, A.S.; Leask, R.M.; Baird, D.T.","year":"1982","unstructured":"Backstrom CT, McNeilly AS, Leask RM, Baird DT. Pulsatile secretion of LH, FSH, prolactin, oestradiol and progesterone during the human minstrual cycle. Clin Endocrinol 1982;17:29-42.","journal-title":"Clin Endocrinol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1210\/jcem-62-6-1136","article-title":"Characterisation ofthe physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle","volume":"62","author":"Fillcori, M.; Santoro, N.; Merrian, G.R.; Crowley, W.F.","year":"1986","unstructured":"Fillcori M, Santoro N, Merrian GR, Crowley WF. Characterisation ofthe physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab 1986;62:1136-44.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1210\/jcem-59-2-328","article-title":"Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin releasing hormone secretion","volume":"59","author":"Reame, N.; Sauder, S.E.; Kelch, R.P.; Marshall, J.C.","year":"1984","unstructured":"Reame N, Sauder SE, Kelch RP, Marshall JC. Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin releasing hormone secretion. 7 Clin Endocrinol Metab 1984;59:328-37.","journal-title":"7 Clin Endocrinol Metab"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0015-0282(16)49151-X","article-title":"Activity ofgonadotropin releasinghormone neurons during the preovulatory luteinising hormone surge","volume":"45","author":"Steele, P.A.; McDonnell, L.F.; Judd, S.J.","year":"1986","unstructured":"Steele PA, McDonnell LF, Judd SJ. Activity ofgonadotropin releasinghormone neurons during the preovulatory luteinising hormone surge. Fertil Steril 1986;45:179-84.","journal-title":"Fertil Steril"},{"key":"ref_8","first-page":"1050","article-title":"Biologically active luteinising hormone is secreted in; episodic pulsations that vary in relation to stage of the menstrual cycle","volume-title":"I Clin EndocrinolMetab","volume":"58","author":"Veldhuis, J.D.; Beitins, I.Z.; Johnson, M.L.; Serabian, M.A.; Dufau, M.L.","year":"1984","unstructured":"Veldhuis JD, Beitins IZ, Johnson ML, Serabian MA, Dufau ML. Biologically active luteinising hormone is secreted in; episodic pulsations that vary in relation to stage of the menstrual cycle. I Clin EndocrinolMetab 1984;58:1050-8."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2265.1984.tb00107.x","article-title":"Pulsatile release of LH and oestradiol during the periovulatory period in women","volume":"20","author":"Diahanbakhch, O.; Warner, P.; McNeilly, A.S.; Baird, D.T.","year":"1984","unstructured":"Diahanbakhch O, Warner P, McNeilly AS, Baird DT. Pulsatile release of LH and oestradiol during the periovulatory period in women. Clin Endocrinol 1984;20:579-89.","journal-title":"Clin Endocrinol"},{"key":"ref_10","first-page":"181","article-title":"Induction of ovulation with pulsatile luteinising hormone releasing hormone","volume":"288","author":"Mason, P.; Adams, J.; Morris, D.V.","year":"1984","unstructured":"Mason P, Adams J, Morris DV, et al. Induction of ovulation with pulsatile luteinising hormone releasing hormone. BrMedJ 1984;288:181-5.","journal-title":"BrMedJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2265.1984.tb03463.x","article-title":"Pulsatile administration of GnRH for the treatment of hypogonadotrophic hypogonadism","volume":"21","author":"Menon, V.; Butt, W.R.; Clayton, R.N.; Logan-Edwards, R.; Lynch, S.S.","year":"1984","unstructured":"Menon V, Butt WR, Clayton RN, Logan-Edwards R, Lynch SS. Pulsatile administration of GnRH for the treatment of hypogonadotrophic hypogonadism. Clin Endocrinol 1984;21: 223-32.","journal-title":"Clin Endocrinol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2265.1985.tb03246.x","article-title":"Determination of the frequency of pulsatile luteinising hormone secretion by time series analysis","volume":"22","author":"Murdoch, A.P.; Diggle, P.J.; Dunlop, W.; Kendall-Taylor, P.","year":"1985","unstructured":"Murdoch AP, Diggle PJ, Dunlop W, Kendall-Taylor P. Determination of the frequency of pulsatile luteinising hormone secretion by time series analysis. Clin Endocrinol 1985;22:341-6.","journal-title":"Clin Endocrinol"},{"key":"ref_13","first-page":"2617","article-title":"Episodic luteinizing horrhone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms. J7 Cln Invest","volume":"52","author":"Santen, R.J.; Bardin, C.W.","year":"1973","unstructured":"Santen RJ, Bardin CW. Episodic luteinizing horrhone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.J7 Cln Invest 1973;52;2617-28."},{"key":"ref_14","first-page":"191","article-title":"Follicular growth and endocrine profiles in spontaneous and induced conception cycles","volume":"45","author":"Eissa, M.K.; Obhrai, M.S.; Docker, M.F.; Lynch, S.S.; Sawers, R.S.; Newton, JR","year":"1986","unstructured":"Eissa MK, Obhrai MS, Docker MF, Lynch SS, Sawers RS, Newton JR. Follicular growth and endocrine profiles in spontaneous and induced conception cycles. FetilSteril 1986;45: 191-5.","journal-title":"FetilSteril"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1210\/jcem-61-6-1126","article-title":"Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease (PCOD) and non-PCOD secondary amenorrhea","volume":"61","author":"Burger, C.W.; Korsen, T.; van Kessel, H.; van Dep, P.A.; Caron, F.J.M.; Schoemaker, J.","year":"1985","unstructured":"Burger CW, Korsen T, van Kessel H, van Dep PA, Caron FJM, Schoemaker J. Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease (PCOD) and non-PCOD secondary amenorrhea. J Clin Endocnrnol Metab 1985;61: 1126-32.","journal-title":"J Clin Endocnrnol Metab"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jcem-62-5-881","article-title":"Physiological properties of the luteinising hormone pulse signal: impact of intensive and extended sampling paradigms on its characterisation in healthy men and women","volume":"62","author":"Veldhuis, J.D.; Evans, W.S.; Johnson, M.L.; Wills, M.R.; Rogol, A.D.","year":"1986","unstructured":"Veldhuis JD, Evans WS, Johnson ML, Wills MR, Rogol AD. Physiological properties of the luteinising hormone pulse signal: impact of intensive and extended sampling paradigms on its characterisation in healthy men and women. J Clin Endotinol Metab 1986;62:881-91.","journal-title":"J Clin Endotinol Metab"},{"key":"ref_17","first-page":"45","article-title":"Progesterone modulation of pulsatile luteinizing hormone secretion in normal women. 7 Clin Endocrinol Metab 1984; 58: 378-83","volume":"15","author":"Soules, M.R.; Steiner, R.A.; Clifton, D.K.; Cohen, N.L.; Aksel, S.; Bremner, W.J.","year":"1983","unstructured":"Soules MR, Steiner RA, Clifton DK, Cohen NL, Aksel S, Bremner WJ. Progesterone modulation of pulsatile luteinizing hormone secretion in normal women. 7 Clin Endocrinol Metab 1984;58:378-83: 19 Laatikainen T, Tulenheimo A, Andersson B, Karkkainen J. Obesity serum steroid levels and pulsatile gonadotrophin secretion in polycystic ovarian disease. EurJ Obstet Gynecol Reprod Biol 1983;15:45-53.","journal-title":"EurJ Obstet Gynecol Reprod Biol; Obesity serum steroid levels and pulsatile gonadotrophin secretion in polycystic ovarian disease"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1471-0528.1984.tb04784.x","article-title":"Pathological mechanisms in polycystic ovary syndrome: modulation of LH pulsatility by progesterone","volume":"91","author":"Molloy, B.G.; El Sheikh, M.A.A.; Chapman, C.; Oakey, R.E.","year":"1984","unstructured":"Molloy BG, El Sheikh MAA, Chapman C, Oakey RE. Pathological mechanisms in polycystic ovary syndrome: modulation of LH pulsatility by progesterone. Br J Obsiet Gynaecol 1984;91:457-65.","journal-title":"Br J Obsiet Gynaecol"},{"key":"ref_19","article-title":"Effect of bromocriptine on LH pulsatility in the polycystic ovary syndrome. Glin Endocrinol","author":"Chapman, A.J.; Wilson, M.D.; Obhrai, M.","unstructured":"Chapman AJ, Wilson MD, Obhrai M, et al. Effect of bromocriptine on LH pulsatility in the polycystic ovary syndrome. Glin Endocrinol (in press)."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1210\/endo-112-3-1057","article-title":"Cycle detection: a technique for estimating the frequency and amplitude of episodic fluctuations in blood hormone and substrate concentrations","volume":"112","author":"Clifton, D.K.; Steiner, R.A.","year":"1983","unstructured":"Clifton DK, Steiner RA. Cycle detection: a technique for estimating the frequency and amplitude of episodic fluctuations in blood hormone and substrate concentrations. Endocrinology 1983;112: 1057-64.","journal-title":"Endocrinology"},{"key":"ref_21","article-title":"Accepted 28","year":"1987","unstructured":"(Accepted 28 May 1987)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.295.6589.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T09:42:01Z","timestamp":1710236521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.295.6589.7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7,4]]},"references-count":21,"journal-issue":{"issue":"6589","published-print":{"date-parts":[[1987,7,4]]}},"URL":"https:\/\/doi.org\/10.1136\/bmj.295.6589.7","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,7,4]]}}}