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Practical gastrointestinal endoscopy. 2nd ed. Oxford: Blackwell Scientific, 1982:44-5.","edition":"2nd ed"},{"key":"ref_2","first-page":"1917","article-title":"The GP and the specialist: gastroenterology","volume":"284","author":"Dyer, N.H.","year":"1982","unstructured":"Dyer NH. The GP and the specialist: gastroenterology. BrMedJ 1982;284:1917-9.","journal-title":"BrMedJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1136\/pgmj.60.709.803","article-title":"The clinical yield of colonoscopy","volume":"60","author":"Williams, C.B.","year":"1984","unstructured":"Williams CB. The clinical yield of colonoscopy. Postgrad MedJ 1984;60:803-10.","journal-title":"Postgrad MedJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archsurg.1982.01380310029007","article-title":"A second look at colonoscopy. Indications, failures, and costs","volume":"117","author":"Abrams, J.S.","year":"1982","unstructured":"Abrams JS. A second look at colonoscopy. Indications, failures, and costs. Arch Surg 1982; 117:913-7.","journal-title":"Arch Surg"},{"key":"ref_5","first-page":"293","article-title":"Complications of gastrointestinal radiologic procedures: I. Complications of routine fluoroscopic studies","volume":"5","author":"Gelfand, D.W.","year":"1980","unstructured":"Gelfand DW. Complications of gastrointestinal radiologic procedures: I. Complications of routine fluoroscopic studies. GastrointestRadiol 1980;5:293-315.","journal-title":"GastrointestRadiol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/bmj.283.6306.1583","article-title":"An evaluation of flexible fibreoptic sigmoidoscopy","volume":"28","author":"Vellacott, K.D.; Hardcastle, J.D.","year":"1981","unstructured":"Vellacott KD, Hardcastle JD. An evaluation of flexible fibreoptic sigmoidoscopy. Br Med J 1981;28: 1583-6.","journal-title":"Br Med J"},{"key":"ref_7","first-page":"34","article-title":"Flexible fibreoptic sigmoidoscopy as an outpatient procedure","volume":"i:","author":"Leicester, R.J.; Hawley, P.R.; Pollett, W.G.; Nicholls, R.J.","year":"1982","unstructured":"Leicester RJ, Hawley PR, Pollett WG, Nicholls RJ. Flexible fibreoptic sigmoidoscopy as an outpatient procedure. Lancet 1982;i:34-5.","journal-title":"Lancet"},{"key":"ref_8","article-title":"Flexible sigmoidoscopy as outpatient procedure","author":"Reynolds, JR, Armitage; NC, Balfour; TW, Hardcastle; J.D.","year":"1983","unstructured":"Reynolds JR, Armitage NC, Balfour TW, Hardcastle JD. Flexible sigmoidoscopy as outpatient procedure. Lancet 1983;ii: 1072.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0140-6736(84)90227-7","article-title":"The flexible sigmoidoscope","volume":"i:","author":"Cobden, I.; Record, C.O.","year":"1984","unstructured":"Cobden I, Record CO. The flexible sigmoidoscope. Lancet 1984;i:55-6.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/bjs.1800690714","article-title":"Comparison of rigid and flexible fibreoptic sigmoidoscopy with double contrast barium enemas","volume":"69","author":"Vellacott, K.D.; Amar, S.S.; Hardcastle, J.D.","year":"1982","unstructured":"Vellacott KD, Amar SS, Hardcastle JD. Comparison of rigid and flexible fibreoptic sigmoidoscopy with double contrast barium enemas. BrJ Surg 1982;69:399-400.","journal-title":"BrJ Surg"},{"key":"ref_11","article-title":"Therapeutic endoscopy and radiology of the gut","author":"Bennett, JR","unstructured":"Bennett JR, ed. Therapeutic endoscopy and radiology of the gut. London: Chapman and Hall, 1981:263."},{"key":"ref_12","first-page":"1033","article-title":"Colonoscopy and the barium enema: a radiological viewpoint","volume":"78","author":"Ott, D.J.; Gelfand, D.W.; Chen, Y.M.; Munitz, H.A.","year":"1985","unstructured":"Ott DJ, Gelfand DW, Chen YM, Munitz HA. Colonoscopy and the barium enema: a radiological viewpoint. South MedJ7 1985;78:1033-5."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-2007-1021584","article-title":"A prospective study of diagnostic methods in adenoma follow-up","volume":"14","author":"Williams, C.B.; Macrae, F.A.; Bartram, C.I.","year":"1982","unstructured":"Williams CB, Macrae FA, Bartram CI. A prospective study of diagnostic methods in adenoma follow-up. Endoscopy 1982;14:74-8.","journal-title":"Endoscopy"},{"key":"ref_14","first-page":"95","article-title":"Is colonoscopy necessary in diverticular disease?","volume":"i:","author":"Boulos, P.B.; Karamanolis, D.G.; Salmon, P.R.; Clark, C.G.","year":"1984","unstructured":"Boulos PB, Karamanolis DG, Salmon PR, Clark CG. Is colonoscopy necessary in diverticular disease? Lancet 1984;i:95-6.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0140-6736(86)92869-2","article-title":"Colonoscopy findings in symptomatic patients without x-ray evidence of colonic neoplasms","volume":"ii:","author":"Aldridge, M.C.; Sim, A.J.W.","year":"1986","unstructured":"Aldridge MC, Sim AJW. Colonoscopy findings in symptomatic patients without x-ray evidence of colonic neoplasms. Lancet 1986;ii:833-4.","journal-title":"Lancet"},{"key":"ref_16","article-title":"Accepted","year":"1987","unstructured":"(Accepted 9 November 1987)"},{"key":"ref_17","article-title":"We report an association between apoB(c) and serum concentrations of apolipoprotein B and low density lipoprotein cholesterol in Finnish children","unstructured":"We report an association between apoB(c) and serum concentrations of apolipoprotein B and low density lipoprotein cholesterol in Finnish children."},{"key":"ref_18","article-title":"and results Serum samples were obtained from 513 children who participated in an ongoing multicentre study on atherosclerosis precursors.2 The children were randomly selected from major cities and rural areas representing different parts of the country. Concentrations of serum lipids and low density lipoprotein and high density lipoprotein cholesterol and body mass index (kg\/M2) were determined2 at the beginning of the study (1980), when the children were 9 years old. Serum apolipoprotein B concentrations were determined and allotypes assayed' in frozen serum that had been stored at -20\u00b0C for about five years. To evaluate the possible effects of storage on serum apolipoprotein B we correlated the present serum Factors related to atherosclerosis in 9year old children according to presence or absence ofapoB(c) allele. Values given are means","author":"Subjects, methods","unstructured":"Subjects, methods, and results Serum samples were obtained from 513 children who participated in an ongoing multicentre study on atherosclerosis precursors.2 The children were randomly selected from major cities and rural areas representing different parts of the country. Concentrations of serum lipids and low density lipoprotein and high density lipoprotein cholesterol and body mass index (kg\/M2) were determined2 at the beginning of the study (1980), when the children were 9 years old. Serum apolipoprotein B concentrations were determined and allotypes assayed' in frozen serum that had been stored at -20\u00b0C for about five years. To evaluate the possible effects of storage on serum apolipoprotein B we correlated the present serum Factors related to atherosclerosis in 9year old children according to presence or absence ofapoB(c) allele. Values given are means (SD)"},{"issue":"35","key":"ref_19","first-page":"0","article-title":"p=Ol p=0-27 p=0-029 p=O 12 p=0-006","volume-title":"apolipoprotein B concentrations with those of the total and low density lipoprotein cholesterol obtained in 1980. Apolipoprotein B concentrations correlated well with the total cholesterol (r=0-757, p<0-001) and low density lipoprotein cholesterol concentrations","volume":"7","author":"p<0-001), which","unstructured":"p=Ol p=0-27 p=0-029 p=O 12 p=0-006 p=0 007 p=035 apolipoprotein B concentrations with those of the total and low density lipoprotein cholesterol obtained in 1980. Apolipoprotein B concentrations correlated well with the total cholesterol (r=0-757, p<0-001) and low density lipoprotein cholesterol concentrations (r=0-809, p<0-001), which supports the hypothesis that the apolipoprotein B had remained intact. Two tailed Bonferroni adjusted t tests were used for multiple comparisons between genotypes with standard BMDP software (University of California)."},{"key":"ref_20","article-title":"We showed significant increases in serum apolipoprotein B and low density lipoprotein cholesterol concentrations in children who had at least one apoB(c) allele compared with children who had none. This receives support from a study that compared the XbaI gene polymorphism with the apoB c\/g polymorphism, which showed a strong association between the apoB(c) allele and the smaller molecular weight XbaI allele in Finnish subjects (Dunning et al, unpublished). The smaller molecular weight XbaI allele is reportedly associated with an increased serum concentration of apolipoprotein B.3 An explanation for the lack ofa gene dosage effect for the apoB(c) allele is not evident from the present results. As suggested for apolipoprotein B gene polymorphisms,4 mapping of additional variations at the gene locus (haplotype analysis) may be necessary to clarify such apparent inconsistencies. Studies along these lines are in progress with antibodies specific for other allotypes","unstructured":"We showed significant increases in serum apolipoprotein B and low density lipoprotein cholesterol concentrations in children who had at least one apoB(c) allele compared with children who had none. This receives support from a study that compared the XbaI gene polymorphism with the apoB c\/g polymorphism, which showed a strong association between the apoB(c) allele and the smaller molecular weight XbaI allele in Finnish subjects (Dunning et al, unpublished). The smaller molecular weight XbaI allele is reportedly associated with an increased serum concentration of apolipoprotein B.3 An explanation for the lack ofa gene dosage effect for the apoB(c) allele is not evident from the present results. As suggested for apolipoprotein B gene polymorphisms,4 mapping of additional variations at the gene locus (haplotype analysis) may be necessary to clarify such apparent inconsistencies. Studies along these lines are in progress with antibodies specific for other allotypes."},{"key":"ref_21","article-title":"The present report links apolipoprotein B allotype with apolipoprotein B concentration and differs from another study that used antibody MB-19, which showed no such association in adults in southern California.5 Subtle","unstructured":"The present report links apolipoprotein B allotype with apolipoprotein B concentration and differs from another study that used antibody MB-19, which showed no such association in adults in southern California.5 Subtle"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.296.6616.167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T22:47:35Z","timestamp":1601074055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.296.6616.167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1,16]]},"references-count":21,"journal-issue":{"issue":"6616","published-print":{"date-parts":[[1988,1,16]]}},"URL":"https:\/\/doi.org\/10.1136\/bmj.296.6616.167","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1,16]]}}}