{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:16Z","timestamp":1787500516749,"version":"build-2736575974"},"reference-count":31,"publisher":"BMJ","issue":"6625","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,3,19]]},"DOI":"10.1136\/bmj.296.6625.814","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"814-816","source":"Crossref","is-referenced-by-count":40,"title":["Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure"],"prefix":"10.1136","volume":"296","author":[{"given":"D E","family":"Grobbee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W H L","family":"Hackeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Birkenhager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1464-410X.1958.tb03498.x","article-title":"Hypertension in hyperparathyroidism","volume":"30","author":"Hellstrom, J.; Birke, G.; Edvall, C.A.","year":"1958","unstructured":"Hellstrom J, Birke G, Edvall CA. Hypertension in hyperparathyroidism. Br] Urol 1958;30: 13-24.","journal-title":"Br] Urol"},{"key":"ref_2","first-page":"1761","article-title":"Primary hyperparathyroidism","volume":"141","author":"Lafferty, F.W.","year":"1981","unstructured":"Lafferty FW. Primary hyperparathyroidism. Arch Intern Med 1981;141:1761-6.","journal-title":"Arch Intern Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0002-9343(83)91162-2","article-title":"Hypertension and hyperparathyroidism","volume":"75","author":"Daniels, J.; Goodman, A.D.","year":"1983","unstructured":"Daniels J, Goodman AD. Hypertension and hyperparathyroidism. Am]7 Med 1983;75:17-23.","journal-title":"Am]7 Med"},{"key":"ref_4","first-page":"396","article-title":"Hypertension and hyperparathyroidism","volume":"iv:","author":"Rosenthal, F.D.; Roy, S.","year":"1972","unstructured":"Rosenthal FD, Roy S. Hypertension and hyperparathyroidism. BrMedJf 1972;iv:396-7.","journal-title":"BrMedJf"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/pgmj.59.692.350","article-title":"Changes in blood pressure and renal function after parathyroidectomy in primary hyperparathyroidism","volume":"59","author":"Jones, D.B.; Lucas, P.A.; Jones, J.H.; Wilkins, W.E.; Lloyd, H.J.; Walker, D.A.","year":"1983","unstructured":"Jones DB, Lucas PA, Jones JH, Wilkins WE, Lloyd HJ, Walker DA. Changes in blood pressure and renal function after parathyroidectomy in primary hyperparathyroidism. Postgrad Med ) 1983;59:350-3.","journal-title":"Postgrad Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.HYP.2.2.162","article-title":"Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak","volume":"2","author":"McCarron, D.A.; Pingree, P.A.; Rubin, R.J.; Gaucher, S.M.; Molitch, M.; Krutzik, S.","year":"1980","unstructured":"McCarron DA, Pingree PA, Rubin RJ, Gaucher SM, Molitch M, Krutzik S. Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak. Hypertension 1980;2: 162-8.","journal-title":"Hypertension"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/cs0650137","article-title":"Abnormalities of calcium metabolism in essential hypertension","volume":"65","author":"Strazzullo, P.; Nunziata, V.; Cirillo, M.","year":"1983","unstructured":"Strazzullo P, Nunziata V, Cirillo M, et al. Abnormalities of calcium metabolism in essential hypertension. Clin Sci 1983;65:137-41.","journal-title":"Clin Sci"},{"key":"ref_8","first-page":"299","article-title":"Intact parathyroid hormone (1-84) in primary hypertension. Clin Exp Hypertens","volume":"8","author":"Grobbee, D.E.; Hackeng, W.H.L.; Birkenhager, J.C.; Hofman, A.","year":"1986","unstructured":"Grobbee DE, Hackeng WHL, Birkenhager JC, Hofman A. Intact parathyroid hormone (1-84) in primary hypertension. Clin Exp Hypertens [A] 1986;8:299-308.","journal-title":"[A]"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0140-6736(86)90228-X","article-title":"Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension","volume":"ii:","author":"Grobbee, D.E.; Hofman, A.","year":"1986","unstructured":"Grobbee DE, Hofman A. Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension. Lancet 1986;ii:703-7.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1210\/jcem-57-5-1007","article-title":"Estimation of biologically active intact parathyroid hormone in normal and hyperparathyroid sera by sequential N-terminal immunoextraction and midregion radioimmunoassay","volume":"57","author":"Lindall, A.W.; Elting, J.; Ells, J.; Roos, B.A.","year":"1983","unstructured":"Lindall AW, Elting J, Ells J, Roos BA. Estimation of biologically active intact parathyroid hormone in normal and hyperparathyroid sera by sequential N-terminal immunoextraction and midregion radioimmunoassay. J Clin EndocrinolMetab 1983;57:1007-14.","journal-title":"J Clin EndocrinolMetab"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/jcem-63-2-447","article-title":"Clinical implications of estimation of intact parathyroid hormone (PTH) versus total immunoreactive PTH in normal subjects and hyperparathyroid patients","volume":"63","author":"Hackeng, W.H.L.; Lips, P.; Netelenbos, J.C.; Lips, C.J.M.","year":"1986","unstructured":"Hackeng WHL, Lips P, Netelenbos JC, Lips CJM. Clinical implications of estimation of intact parathyroid hormone (PTH) versus total immunoreactive PTH in normal subjects and hyperparathyroid patients. ] Clin Endocrinol Metab 1986;63:447-53.","journal-title":"Clin Endocrinol Metab"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/oxfordjournals.aje.a113607","article-title":"Determinants of change in blood pressure during childhood","volume":"117","author":"Hofman, A.; Valkenburg, H.A.","year":"1983","unstructured":"Hofman A, Valkenburg HA. Determinants of change in blood pressure during childhood. Am]I Epidemiol 1983;117:735-43.","journal-title":"Am]I Epidemiol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJM196803212781206","article-title":"Relative importance of parathyroid hormone and thyrocalcitonin in calcium homeostasis","volume":"278","author":"Sherwood, L.M.","year":"1968","unstructured":"Sherwood LM. Relative importance of parathyroid hormone and thyrocalcitonin in calcium homeostasis. N Engl3 Med 1968;278:663-70.","journal-title":"N Engl3 Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1126\/science.6729459","article-title":"Blood pressure and nutrient intake in the United States","volume":"224","author":"McCarron, D.A.; Morris, C.D.; Henry, H.J.; Stanton, J.L.","year":"1984","unstructured":"McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science 1984;224:1392-8.","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1056\/NEJM198404263101705","article-title":"Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy","volume":"310","year":"1984","unstructured":"Erne P, Bolli P, Burgisser E, Buhler FR. Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy. N Engli Med 1984;310: 1084-8.","journal-title":"N Engli Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.HYP.8.1.11","article-title":"Serum calcium fractions in essential hypertensive and matched control subjects","volume":"8","author":"Folsom, A.R.; Smith, C.L.; Prineas, R.J.; Grimm, R.H.","year":"1986","unstructured":"Folsom AR, Smith CL, Prineas RJ, Grimm RH. Serum calcium fractions in essential hypertensive and matched control subjects. Hypertension 1986;8:11-5.","journal-title":"Hypertension"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/physrev.1984.64.3.985","article-title":"Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism","volume":"64","author":"Habener, J.F.; Rosenblatt, M.; Potts, J.T.","year":"1984","unstructured":"Habener JF, Rosenblatt M, Potts JT. Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev 1984;64:985-1053.","journal-title":"Physiol Rev"},{"key":"ref_18","first-page":"114","article-title":"Raised plasma noradrenaline, adrenaline and dopamine levels in young subjects with mild hypertension","volume":"19","author":"Grobbee, D.E.; Boomsa, F.; Schalekamp, M.A.D.H.; Hofman, A.","year":"1985","unstructured":"Grobbee DE, Boomsa F, Schalekamp MADH, Hofman A. Raised plasma noradrenaline, adrenaline and dopamine levels in young subjects with mild hypertension. Pediatr Res 1985;19: 114.","journal-title":"Pediatr Res"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00004872-198410000-00002","article-title":"Altered calcium handling as a cause of primary hypertension","volume":"2","author":"Robinson, B.F.","year":"1984","unstructured":"Robinson BF. Altered calcium handling as a cause of primary hypertension. J Hypertens 1984;2:453-60.","journal-title":"J Hypertens"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.7326\/0003-4819-105-6-947","article-title":"The calcium deficiency hypothesis of hypertension: a critique","volume":"105","author":"Kaplan, N.M.; Meese, R.B.","year":"1986","unstructured":"Kaplan NM, Meese RB. The calcium deficiency hypothesis of hypertension: a critique. Ann Intern Med 1986;105:947-55.","journal-title":"Ann Intern Med"},{"key":"ref_21","first-page":"202","article-title":"Chronic PTH infusion results in hypertension in normal subjects","volume":"25","author":"Hulter, H.N.; Melby, J.C.; Peterson, J.C.; Cooke, C.R.","year":"1984","unstructured":"Hulter HN, Melby JC, Peterson JC, Cooke CR. Chronic PTH infusion results in hypertension in normal subjects. Kidney Int 1984;25:202.","journal-title":"Kidney Int"},{"key":"ref_22","first-page":"365","article-title":"Parathyroid hormone-desoxicortisone acetate induced hypertension in the rat","volume":"58","author":"Berthelot, A.; Gairard, A.","year":"1980","unstructured":"Berthelot A, Gairard A. Parathyroid hormone-desoxicortisone acetate induced hypertension in the rat. ClinSci 1980;58:365-71.","journal-title":"ClinSci"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1172\/JCI110505","article-title":"Effect of parathyroid hormone on osmotic fragility of human erythrocytes","volume":"69","author":"Bogin, E.; Massry, S.G.; Levi, J.; Djaldeti, M.; Bristol, G.; Smith, J.","year":"1982","unstructured":"Bogin E, Massry SG, Levi J, Djaldeti M, Bristol G, Smith J. Effect of parathyroid hormone on osmotic fragility of human erythrocytes. J Clin Invest 1982;69:1017-25.","journal-title":"J Clin Invest"},{"key":"ref_24","article-title":"Calcium and blood pressure","author":"Palmieri, G.M.A.; Bertorini, T.E.; Nutting, D.F.","year":"1986","unstructured":"Palmieri GMA, Bertorini TE, Nutting DF. Calcium and blood pressure. Lancet 1986;ii: 1106.","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1139\/y86-137","article-title":"Alterations of calcium intake as a therapeutic modality in essential hypertension","volume":"64","author":"Resnick, L.M.","year":"1986","unstructured":"Resnick LM. Alterations of calcium intake as a therapeutic modality in essential hypertension. Can]J Physiol Pharmaco! 1986;64:803-7.","journal-title":"Can]J Physiol Pharmaco!"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0140-6736(86)90554-4","article-title":"Calcium and blood pressure","volume":"ii:","author":"Henningsen, N.C.; Jaedig, S.; Reuterssvaed, A.","year":"1986","unstructured":"Henningsen NC, Jaedig S, Reuterssvaed A. Calcium and blood pressure. Lancet 1986;ii: 1154-5.","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0140-6736(87)91766-1","article-title":"Parathyroid hormone, electrolytes, and blood pressure","volume":"i:","author":"Grobbee, D.E.","year":"1987","unstructured":"Grobbee DE. Parathyroid hormone, electrolytes, and blood pressure. Lancet 1987;i:389.","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1253\/jcj.45.1272","article-title":"Parathyroids, thyroid and development of hypertension in SHR","volume":"45","author":"Schleiffer, R.; Berthelot, A.; Pernot, F.; Gairard, A.","year":"1981","unstructured":"Schleiffer R, Berthelot A, Pernot F, Gairard A. Parathyroids, thyroid and development of hypertension in SHR.J3pn Circ J 1981;45:1272-9.","journal-title":"J3pn Circ J"},{"key":"ref_29","first-page":"58","article-title":"Boxplots and batch comparison","volume-title":"Understanding robust and exploratory data analysis","author":"Emerson, J.D.; Strenio, J.","year":"1983","unstructured":"Emerson JD, Strenio J. Boxplots and batch comparison. In: Haoglin DC, Mosteller F, Tukey JW, eds. Understanding robust and exploratory data analysis. New York: John Wiley and Sons, 1983:58-96."},{"key":"ref_30","article-title":"Accepted 17","year":"1987","unstructured":"(Accepted 17 November 1987)"},{"issue":"10","key":"ref_31","article-title":"speaking at the annual dinner of the Association of Public Sanitary Inspectors on Saturday last, observed that it was important that time should be given to the Boundary Commissioners to make their examinations full and complete, as much of the reform needed would only come from larger areas than the present small administrative ones being provided for poor-law and sanitary purposes. He also urged that the scattered and weakened functions now spread over several Government departments should be consolidated under a Minister of Health. In conclusion he referred","volume-title":"Lancashire manufacturers had an offer now made to them to work their engines by gas at two-thirds the price of working them by the flame of coal. This plan was proposed by the speaker thirty years ago; and there was no doubt that this might be done, and, when done, down would fall the big chimney which befouled all around with its smoke and dirt","volume":"3","author":"CHADWICK, E.D.W.I.N.; B, C.","year":"1888","unstructured":"MR. EDWIN CHADWICK, C.B., speaking at the annual dinner of the Association of Public Sanitary Inspectors on Saturday last, observed that it was important that time should be given to the Boundary Commissioners to make their examinations full and complete, as much of the reform needed would only come from larger areas than the present small administrative ones being provided for poor-law and sanitary purposes. He also urged that the scattered and weakened functions now spread over several Government departments should be consolidated under a Minister of Health. In conclusion he referred to the fact that the Lancashire manufacturers had an offer now made to them to work their engines by gas at two-thirds the price of working them by the flame of coal. This plan was proposed by the speaker thirty years ago; and there was no doubt that this might be done, and, when done, down would fall the big chimney which befouled all around with its smoke and dirt. (British MedicalJournal 1888;i:3 10)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.296.6625.814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:50:32Z","timestamp":1601059832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.296.6625.814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,19]]},"references-count":31,"journal-issue":{"issue":"6625","published-print":{"date-parts":[[1988,3,19]]}},"URL":"https:\/\/doi.org\/10.1136\/bmj.296.6625.814","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3,19]]}}}