{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:02:24Z","timestamp":1770721344801,"version":"3.49.0"},"reference-count":27,"publisher":"BMJ","issue":"6649","license":[{"start":{"date-parts":[[1988,9,10]],"date-time":"1988-09-10T00:00:00Z","timestamp":589852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,9,10]]},"abstract":"<jats:p>There is strong circumstantial evidence that human papillomavirus is a cofactor in the development of cervical neoplasia. Systemic immunosuppression has also been implicated. A study was therefore carried out examining the relation between subtypes of human papillomavirus and local immunocompetent cells in the cervix. Colposcopically directed punch biopsy specimens were taken from normal cervix and from histologically proved cervical intraepithelial neoplasia for immunohistochemical studies. Human papillomavirus genome probing was performed on the abnormal specimens. A relation was apparent between decreased Langerhans' cells and moderate to high copy numbers of human papillomavirus type 16. The reduction in Langerhans' cells was significant for human papillomavirus type 18 even at low copy numbers. Conversely, the absence of human papillomavirus was associated with increased numbers of Langerhans' cells in cervical intraepithelial neoplasia. These findings suggest that the proposed oncogenic potential of human papillomavirus type 16 and human papillomavirus type 18 in particular may be mediated by a specific effect on the afferent limb of the immune response.<\/jats:p>","DOI":"10.1136\/bmj.297.6649.643","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"643-646","source":"Crossref","is-referenced-by-count":46,"title":["Langerhans' cells and subtypes of human papillomavirus in cervical intraepithelial neoplasia."],"prefix":"10.1136","volume":"297","author":[{"given":"R. J.","family":"Hawthorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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Br Med J 1988;296:381-5.","journal-title":"Br Med J"},{"key":"ref_15","first-page":"412","article-title":"Langerhans' cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia","volume-title":"Br3r Obstet Gynaecol","volume":"90","author":"Morris, H.H.B.; Gatter, K.C.; Sykes, G.; Casemore, V.; Mason, D.Y.","year":"1983","unstructured":"Morris HHB, Gatter KC, Sykes G, Casemore V, Mason DY. Langerhans' cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia. Br3r Obstet Gynaecol 1983;90:412-20."},{"issue":"1","key":"ref_16","first-page":"145","article-title":"Cervical healing and Langerhans' cells. BrJ7 Obstet Gvnaecol","volume":"91","author":"MacLean, A.B.","year":"1984","unstructured":"MacLean AB. Cervical healing and Langerhans' cells. 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Langerhans' cells in human cervical epithelium. Brj Obstet Gynaecol 1983;90:400-1 1.","journal-title":"Brj Obstet Gynaecol"},{"key":"ref_21","first-page":"974","article-title":"Langerhans' cells and lymphocyte subsets in the female genital tract. BrJ3 Obstet Gynaecol","volume":"92","author":"Edwards, J.N.T.; Morris, H.B.","year":"1985","unstructured":"Edwards JNT, Morris HB. Langerhans' cells and lymphocyte subsets in the female genital tract. BrJ3 Obstet Gynaecol 1985;92:974-82."},{"key":"ref_22","first-page":"1069","article-title":"Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies. Br7 Obstet Gynaecol","volume":"90","author":"Morris, H.B.; Gatter, K.C.; Pulford, K.","year":"1983","unstructured":"Morris HB, Gatter KC, Pulford K, et al. Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies. 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