{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:33:35Z","timestamp":1791160415937,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"6651","license":[{"start":{"date-parts":[[1988,9,24]],"date-time":"1988-09-24T00:00:00Z","timestamp":591062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1988,9,24]]},"abstract":"<jats:p>A total of 22,552 workers employed by the Atomic Weapons Establishment between 1951 and 1982 were followed up for an average of 18.6 years. Of the 3115 who died, 865 (28%) died of cancer. Mortality was 23% lower than the national average for all causes of death and 18% lower for cancer. These low rates were consistent with the findings in other workforces in the nuclear industry and reflect, at least in part, the selection of healthy people to work in the industry and the disproportionate recruitment of people from the higher social classes. At some time during their employment 9389 (42%) of the workers were monitored for exposure to radiation, the average cumulative whole body exposure to external radiation being 7.8 mSv. Their mortality was generally similar to that of other employees, even when exposures were lagged by 10 years. The rate ratio after a 10 year lag in workers with a radiation record compared with other workers was 1.01 (95% confidence interval 0.92 to 1.10) for all causes of death and 1.06 (0.89 to 1.27) for all malignant neoplasms. The only significant differences were for prostatic cancer (rate ratio 2.23; 95% confidence interval 1.13 to 4.40) and for cancers of ill defined and secondary sites (rate ratio 2.37; 1.23 to 4.56). Cancers of lymphatic and haemopoietic tissues were notable for their low occurrence in the study population, with only four deaths from leukaemia and two from multiple myeloma in workers with a radiation record, 9.16 and 3.55 deaths respectively being expected on the basis of national rates. Among workers who had a radiation record 3742 (40%) were also monitored for possible internal exposure to plutonium, 3044 (32%) to uranium, 1562 (17%) to tritium, 638 (7%) to polonium, and 281 (3%) to actinium. In these workers mortality from malignant neoplasms as a whole was not increased, but after a 10 year lag death rates from prostatic and renal cancers were generally more than twice the national average, these excesses arising in a small group of workers monitored for exposure to multiple radionuclides. Though mortality from lung cancer in workers monitored for exposure to plutonium was below the national average, it was some two thirds higher than in other radiation workers, the excess being of borderline statistical significance. Mortality from malignant neoplasms as a whole showed a weak and non-significant increasing trend with increasing level of cumulative whole body exposure to external radiation. When the exposures were lagged by 10 years the trend became stronger and significant, the estimated increase in relative risk per 10 mSv being 7.6% (95% confidence interval 0.4% to 15.3%). This trend was confined almost entirely to workers who were also monitored for exposure to radionuclides (p&lt;0.001), the main contributions coming from lung cancer and prostatic cancer. Exposures of the lung and prostate from internal sources of radiation were not quantified, except for the contribution from tritium. It was therefore not possible to assess the extent to which the associations were due to internally deposited radionuclides rather than external exposure. The finding for prostatic cancer taken in conjunction with the results of other studies suggest a specific occupational hazard in a small group of workers in the nuclear industry who had comparatively high exposures to external radiation and who were also monitored for internal exposure to multiple radionuclides. Research is needed to discover whether any of the radionuclides and other substances concerned are concentrated in the prostate. The occurrence of lung cancer in this workforce requires further investigation taking into account smoking habits and tissue doses from inhaled radionuclides.<\/jats:p>","DOI":"10.1136\/bmj.297.6651.757","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:19:55Z","timestamp":1238685595000},"page":"757-770","source":"Crossref","is-referenced-by-count":95,"title":["Mortality of employees of the Atomic Weapons Establishment, 1951-82."],"prefix":"10.1136","volume":"297","author":[{"given":"V.","family":"Beral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,9,24]]},"reference":[{"key":"ref_1","first-page":"122","article-title":"An analysis of the mortality of workers in a nuclear facility","volume":"79","author":"Gilbert, E.S.; Marks, S.","year":"1979","unstructured":"Gilbert ES, Marks S. An analysis of the mortality of workers in a nuclear facility. RadiatRes 1979;79:122-48.","journal-title":"RadiatRes"},{"key":"ref_2","first-page":"231","article-title":"Cancer mortality at a naval nuclear shipyard","volume":"i:","author":"Rinsky, R.A.; Zumwalde, R.D.; Waxweiler, R.J.","year":"1981","unstructured":"Rinsky RA, Zumwalde RD, Waxweiler RJ, et al. Cancer mortality at a naval nuclear shipyard. Lancet 1981;i:231-5.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00043764-198301000-00015","article-title":"Mortality and cancer incidence experience of employees in a nuclear fuels fabrication plant","volume":"25","author":"Hadjimichael, O.C.; Ostfeld, A.M.; D'Atri, D.A.; Brubaker, R.E.","year":"1983","unstructured":"Hadjimichael OC, Ostfeld AM, D'Atri DA, Brubaker RE. Mortality and cancer incidence experience of employees in a nuclear fuels fabrication plant.J Occup Med 1983;25:48-61.","journal-title":"J Occup Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2307\/3576087","article-title":"A further update on the analysis of mortality of workers in a nuclear facility","volume":"95","author":"Tolley, H.D.; Marks, S.; Buchanan, J.A.; Gilbert, E.S.","year":"1983","unstructured":"Tolley HD, Marks S, Buchanan JA, Gilbert ES. A further update on the analysis of mortality of workers in a nuclear facility. Radiat Res 1983;95: 211-3.","journal-title":"Radiat Res"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00043764-198410000-00009","article-title":"Brain tumors at a nuclear facility","volume":"26","author":"Reyes, M.; Wilkinson, G.S.; Tietien, G.; Voelz, G.L.; Acquavella, J.F.; Bistline, R.","year":"1984","unstructured":"Reyes M, Wilkinson GS, Tietien G, Voelz GL, Acquavella JF, Bistline R. Brain tumors at a nuclear facility. J Occup Med 1984;26:721-4.","journal-title":"J Occup Med"},{"key":"ref_6","first-page":"435","article-title":"Collection and validation of data in the United Kingdom Atomic Energy Authority mortality study","volume":"291","author":"Fraser, P.; Booth, M.; Beral, V.; Inskip, H.; Firsht, S.; Speak, S.","year":"1985","unstructured":"Fraser P, Booth M, Beral V, Inskip H, Firsht S, Speak S. Collection and validation of data in the United Kingdom Atomic Energy Authority mortality study. BrMedJ 1985;291:435-9.","journal-title":"BrMedJ"},{"key":"ref_7","first-page":"440","article-title":"Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-79","volume":"291","author":"Beral, V.; Inskip, H.; Fraser, P.; Booth, M.; Coleman, D.; Rose, G.","year":"1985","unstructured":"Beral V, Inskip H, Fraser P, Booth M, Coleman D, Rose G. Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-79. BrMedJ 1985;291:440-7.","journal-title":"BrMedJ"},{"key":"ref_8","first-page":"525","article-title":"Radiation, work experience, and cause specific mortality among workers at an energy research laboratory","volume":"42","author":"Checkoway, H.; Mathew, R.M.; Shy, C.M.","year":"1985","unstructured":"Checkoway H, Mathew RM, Shy CM, et al. Radiation, work experience, and cause specific mortality among workers at an energy research laboratory. BrJ IndMed 1985;42:525-33.","journal-title":"BrJ IndMed"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/00004032-198506000-00002","article-title":"Mortality among workers at the Pantex weapons facility","volume":"48","author":"Acquavella, J.F.; Wiggs, L.D.; Waxweiler, R.J.; MacDonell, D.G.; Tietjen, G.L.; Wilkinson, G.S.","year":"1985","unstructured":"Acquavella JF, Wiggs LD, Waxweiler RJ, MacDonell DG, Tietjen GL, Wilkinson GS. Mortality among workers at the Pantex weapons facility. Health Phys 1985;48:735-46.","journal-title":"Health Phys"},{"key":"ref_10","first-page":"845","article-title":"Mortality of workers at the Sellafield plant of British Nuclear Fuels","volume":"293","author":"Smith, P.G.; Douglas, A.J.","year":"1986","unstructured":"Smith PG, Douglas AJ. Mortality of workers at the Sellafield plant of British Nuclear Fuels. BrMedj 1986;293:845-54.","journal-title":"BrMedj"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/oxfordjournals.aje.a114523","article-title":"Mortality among plutonium and other radiation workers at a plutonium weapons facility","volume":"125","author":"Wilkinson, G.S.; Tietjen, G.L.; Wiggs, L.D.","year":"1987","unstructured":"Wilkinson GS, Tietjen GL, Wiggs LD, et al. Mortality among plutonium and other radiation workers at a plutonium weapons facility. 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Case-control study of lung cancer in civilian employees at the Portsmouth naval shipyard, Kittery, Maine. AmJEpidemiol 1988;127:55-64."},{"key":"ref_14","article-title":"Population Censuses and Surveys. Classification of occupations 1970","author":"Office of","year":"1970","unstructured":"Office of Population Censuses and Surveys. Classification of occupations 1970. London: HMSO, 1970."},{"key":"ref_15","article-title":"International classification of diseases, injuries and causes ofdeath","author":"World Health Organisation","year":"1965","unstructured":"World Health Organisation. International classification of diseases, injuries and causes ofdeath. 8th Revision, 1965. Geneva: WHO, 1967.","journal-title":"8th Revision"},{"key":"ref_16","article-title":"International classification of diseases, injuries and causes ofdeath","author":"World Health Organisation","year":"1975","unstructured":"World Health Organisation. International classification of diseases, injuries and causes ofdeath. 9th Revision, 1975. Geneva: WHO, 1977.","journal-title":"9th Revision"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1088\/0260-2814\/5\/4\/001","article-title":"Estimation of below measurement threshold doses following the remeasurement of a sample of old films","volume":"5","author":"Smith, J.W.; Inskip, H.","year":"1985","unstructured":"Smith JW, Inskip H. Estimation of below measurement threshold doses following the remeasurement of a sample of old films. Journal of the Society for Radiological Protection 1985;5:159-64.","journal-title":"Journal of the Society for Radiological Protection"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2307\/2528501","article-title":"Significance factors for the ratio of a Poisson variable to its expectation","volume":"20","author":"Bailar, J.C.; Ederer, F.","year":"1964","unstructured":"Bailar JC, Ederer F. Significance factors for the ratio of a Poisson variable to its expectation. Biometrics 1964;20:639-43.","journal-title":"Biometrics"},{"key":"ref_19","first-page":"97","article-title":"Statistical methods in cancer research. Vol II. The design and analysis of cohort studies","volume-title":"Radiation and health; IARC scientific publications, No 82.) 21 Office of Population Censuses and Surveys. Occupational mortality, 1970-72. Decennial supplement","volume":"23","author":"Breslow, N.E.; Day, N.E.","year":"1987","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research. Vol II. The design and analysis of cohort studies. Lyons: International Agency for Research on Cancer, 1987. (IARC scientific publications, No 82.) 21 Office of Population Censuses and Surveys. Occupational mortality, 1970-72. Decennial supplement. London: HMSO, 1978. (Series DS, No 1.) 22 Day NE, Boice JD Jr, eds. Second cancer in relation to radiation treatment for cervical cancer. Lyons: International Agency for Research on Cancer, 1983. (IARC scientific publications, No 52.) 23 Beral V, Fraser P, Booth M, Carpenter L. Epidemiological studies of workers in the nuclear industry. In: Russell Jones R, Southwood R, eds. Radiation and health. Chichester: Wiley, 1987:97-106."},{"key":"ref_20","first-page":"95","article-title":"The \"healthy worker effect\" and other determinants of mortality in workers in the nuclear industry. In: Health effects oflow dose ionising radiation-recent advances and their implications","volume":"1988","author":"Beral, V.; Carpenter, L.; Booth, M.; Inskip, H.; Brown, A.","unstructured":"Beral V, Carpenter L, Booth M, Inskip H, Brown A. The \"healthy worker effect\" and other determinants of mortality in workers in the nuclear industry. In: Health effects oflow dose ionising radiation-recent advances and their implications. London: British Nuclear Energy Society, 1988:95-100.","journal-title":"London: British Nuclear Energy Society"},{"key":"ref_21","first-page":"1","article-title":"Life span study report 11. Part 1. Comparison of risk coefficients for site-specific cancer mortality based on the DS86 and T65DR shielded Kerma and Organ doses","volume":"12","author":"Shimizu, Y.; Kato, H.; Schull, W.J.; Preston, D.L.; Fujita, S.; Pierce, D.A.","year":"1987","unstructured":"Shimizu Y, Kato H, Schull WJ, Preston DL, Fujita S, Pierce DA. Life span study report 11. Part 1. Comparison of risk coefficients for site-specific cancer mortality based on the DS86 and T65DR shielded Kerma and Organ doses. Radiation Effects Research Foundation Technical Report Series 1987; No 12:1-56.","journal-title":"Radiation Effects Research Foundation Technical Report Series"},{"key":"ref_22","first-page":"1","article-title":"Prostate cancer: epidemiology","volume":"78","author":"Alderson, M.R.","year":"1981","unstructured":"Alderson MR. Prostate cancer: epidemiology. Recent Results Cancer Res 1981;78: 1-19.","journal-title":"Recent Results Cancer Res"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1289\/ehp.8140107","article-title":"Role ofcadmium in carcinogenesis with special reference to cancer of the prostate","volume":"40","author":"Piscator, M.","year":"1981","unstructured":"Piscator M. Role ofcadmium in carcinogenesis with special reference to cancer of the prostate. Environ Health Perspect 1981;40:107-20.","journal-title":"Environ Health Perspect"},{"key":"ref_24","first-page":"67","article-title":"Epidemiological studies of employees of the United Kingdom Atomic Energy Authority. In: Health effects of low dose ionising radiation-recent advances and their implications","volume":"1988","author":"Fraser, P.; Beral, V.; Booth, M.; Inskip, H.; Carpenter, L.","unstructured":"Fraser P, Beral V, Booth M, Inskip H, Carpenter L. Epidemiological studies of employees of the United Kingdom Atomic Energy Authority. In: Health effects of low dose ionising radiation-recent advances and their implications. London: British Nuclear Energy Society, 1988:67-70.","journal-title":"London: British Nuclear Energy Society"},{"key":"ref_25","article-title":"Uranium, plutonium and the transplutonic elements","author":"Hodge, H.C.; Stannard, J.N.; Hursh, J.B.","year":"1973","unstructured":"Hodge HC, Stannard JN, Hursh JB. Uranium, plutonium and the transplutonic elements. New York: Springer Verlag, 1973."},{"key":"ref_26","first-page":"823","article-title":"Mortality follow-up through 1977 of the white underground uranium miners cohort examined by the United States Public Health Service","volume-title":"Radiation hazards in mining","author":"Waxweiler, R.J.; Roscoe, R.J.; Archer, V.E.; Thun, M.J.; Wagoner, J.K.; FE, Jr, Lundin","year":"1981","unstructured":"Waxweiler RJ, Roscoe RJ, Archer VE, Thun MJ, Wagoner JK, Lundin FE Jr. Mortality follow-up through 1977 of the white underground uranium miners cohort examined by the United States Public Health Service. In: Gomez M, ed. Radiation hazards in mining. Kingsport: Kingsport Press, 1981:823-30."},{"key":"ref_27","first-page":"1","article-title":"Intemational Commission for Radiological Protection. Limits of intakes of radionuclides by workers. Part 1","volume":"30","year":"1979","unstructured":"Intemational Commission for Radiological Protection. Limits of intakes of radionuclides by workers. Part 1. Ann ICRP 1979;No 30:1-116."},{"key":"ref_28","article-title":"Report of an investigation into radiological health and safety at the Ministry of Defence (Procurement Executive) Atomic Weapons Research Establishment, Aldermaston","author":"Pochin, E.","year":"1978","unstructured":"Pochin E. Report of an investigation into radiological health and safety at the Ministry of Defence (Procurement Executive) Atomic Weapons Research Establishment, Aldermaston. Harwell, Oxfordshire: Atomic Weapons Research Establishment, 1978."},{"key":"ref_29","first-page":"1","article-title":"The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors","volume":"9","author":"Preston, D.L.; Pierce, D.A.","year":"1987","unstructured":"Preston DL, Pierce DA. The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors. 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